Biochemical and histological effects of low dose of monosodium glutamate on the liver of adult male Sprague-Dawley rats

Monosodium glutamate (MSG) is widely used as an additive in food. Excess consumption of MSG was reported to cause oxidative stress on brain, liver and renal resulted in increased production of reactive oxygen species (ROS). This study aims to determine the biochemical and histological effects of low...

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Main Authors:	Siti Fathiah Masre, Nur Athirah Razali, Nur Naimah Nani, Izatus Shima Taib
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:	http://journalarticle.ukm.my/13455/ http://journalarticle.ukm.my/13455/ http://journalarticle.ukm.my/13455/1/32045-104276-1-PB.pdf

id	ukm-13455
recordtype	eprints
spelling	ukm-134552019-09-28T07:05:04Z http://journalarticle.ukm.my/13455/ Biochemical and histological effects of low dose of monosodium glutamate on the liver of adult male Sprague-Dawley rats Siti Fathiah Masre, Nur Athirah Razali, Nur Naimah Nani, Izatus Shima Taib, Monosodium glutamate (MSG) is widely used as an additive in food. Excess consumption of MSG was reported to cause oxidative stress on brain, liver and renal resulted in increased production of reactive oxygen species (ROS). This study aims to determine the biochemical and histological effects of low dose MSG on the liver of adult male Sprague-Dawley rats. Animals (n = 6 per group) were randomly divided into three groups with two treatment groups: 60 mg/kg (MSG60) and 120 mg/kg (MSG120), and one control group (distilled water). The substances were administered to the rats via force feeding for 28 consecutive days. On day 29, all rats were killed, and liver tissues were biopsied for the biochemical (total protein, liver enzymes, and the status of oxidative stress) and histological analysis. The total protein appeared significantly decreased (p < 0.05) while alanine aminotransferase (ALT) and aspartate aminotransferase (AST) demonstrated a significant increased (p < 0.05) in the MSG120 treatment group as compared to the control group. Malondialdehyde (MDA) levels and the antioxidant levels of superoxide dismutase (SOD) were significantly increase (p < 0.05) in the MSG120 group as compared to the MSG60 and control groups. The histological findings revealed changes to normal liver architecture and accumulation of red blood cells in the central veins in both MSG groups. This study indicates that the MSG consumption at a dose of 120 mg/kg may ALTer the biochemical and histological parameters of the liver. Penerbit Universiti Kebangsaan Malaysia 2019 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/13455/1/32045-104276-1-PB.pdf Siti Fathiah Masre, and Nur Athirah Razali, and Nur Naimah Nani, and Izatus Shima Taib, (2019) Biochemical and histological effects of low dose of monosodium glutamate on the liver of adult male Sprague-Dawley rats. Jurnal Sains Kesihatan Malaysia, 17 (2). pp. 107-112. ISSN 1675-8161 http://ejournal.ukm.my/jskm/issue/view/687
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Monosodium glutamate (MSG) is widely used as an additive in food. Excess consumption of MSG was reported to cause oxidative stress on brain, liver and renal resulted in increased production of reactive oxygen species (ROS). This study aims to determine the biochemical and histological effects of low dose MSG on the liver of adult male Sprague-Dawley rats. Animals (n = 6 per group) were randomly divided into three groups with two treatment groups: 60 mg/kg (MSG60) and 120 mg/kg (MSG120), and one control group (distilled water). The substances were administered to the rats via force feeding for 28 consecutive days. On day 29, all rats were killed, and liver tissues were biopsied for the biochemical (total protein, liver enzymes, and the status of oxidative stress) and histological analysis. The total protein appeared significantly decreased (p < 0.05) while alanine aminotransferase (ALT) and aspartate aminotransferase (AST) demonstrated a significant increased (p < 0.05) in the MSG120 treatment group as compared to the control group. Malondialdehyde (MDA) levels and the antioxidant levels of superoxide dismutase (SOD) were significantly increase (p < 0.05) in the MSG120 group as compared to the MSG60 and control groups. The histological findings revealed changes to normal liver architecture and accumulation of red blood cells in the central veins in both MSG groups. This study indicates that the MSG consumption at a dose of 120 mg/kg may ALTer the biochemical and histological parameters of the liver.
format	Article
author	Siti Fathiah Masre, Nur Athirah Razali, Nur Naimah Nani, Izatus Shima Taib,
spellingShingle	Siti Fathiah Masre, Nur Athirah Razali, Nur Naimah Nani, Izatus Shima Taib, Biochemical and histological effects of low dose of monosodium glutamate on the liver of adult male Sprague-Dawley rats
author_facet	Siti Fathiah Masre, Nur Athirah Razali, Nur Naimah Nani, Izatus Shima Taib,
author_sort	Siti Fathiah Masre,
title	Biochemical and histological effects of low dose of monosodium glutamate on the liver of adult male Sprague-Dawley rats
title_short	Biochemical and histological effects of low dose of monosodium glutamate on the liver of adult male Sprague-Dawley rats
title_full	Biochemical and histological effects of low dose of monosodium glutamate on the liver of adult male Sprague-Dawley rats
title_fullStr	Biochemical and histological effects of low dose of monosodium glutamate on the liver of adult male Sprague-Dawley rats
title_full_unstemmed	Biochemical and histological effects of low dose of monosodium glutamate on the liver of adult male Sprague-Dawley rats
title_sort	biochemical and histological effects of low dose of monosodium glutamate on the liver of adult male sprague-dawley rats
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2019
url	http://journalarticle.ukm.my/13455/ http://journalarticle.ukm.my/13455/ http://journalarticle.ukm.my/13455/1/32045-104276-1-PB.pdf
first_indexed	2023-09-18T20:04:54Z
last_indexed	2023-09-18T20:04:54Z
_version_	1777407092683964416

Biochemical and histological effects of low dose of monosodium glutamate on the liver of adult male Sprague-Dawley rats

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