Transformation of Melinjo seed micropowders into nanopowders enhances extractability of phenolic compounds and tyrosinase inhibitory activity

Melinjo (Gnetum gnemon L.) seed powder extract exhibited antioxidant and tyrosinase inhibitory activity, thus showing potential as a dietary supplement or nutraceutical to prevent aging or hyperpigmentation. Previously, we found that particle size plays important role in extraction of bioactive comp...

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Main Authors:	Vienna Saraswaty, Suparta, Ni Wayan Wulan Prawerti, Setiyanto, Henry, Rachmawati, Heni, Adnyana, I Ketut
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:	http://journalarticle.ukm.my/13619/ http://journalarticle.ukm.my/13619/ http://journalarticle.ukm.my/13619/1/06%20Vienna%20Saraswaty.pdf

id	ukm-13619
recordtype	eprints
spelling	ukm-136192019-11-10T03:27:55Z http://journalarticle.ukm.my/13619/ Transformation of Melinjo seed micropowders into nanopowders enhances extractability of phenolic compounds and tyrosinase inhibitory activity Vienna Saraswaty, Suparta, Ni Wayan Wulan Prawerti Setiyanto, Henry Rachmawati, Heni Adnyana, I Ketut Melinjo (Gnetum gnemon L.) seed powder extract exhibited antioxidant and tyrosinase inhibitory activity, thus showing potential as a dietary supplement or nutraceutical to prevent aging or hyperpigmentation. Previously, we found that particle size plays important role in extraction of bioactive compounds and influences their bioactivity. Thus, it is important to determine a certain particle size for the extraction process. In this study, we investigated the effects of transformation of melinjo seed micropowders into nanopowders by nanomilling using a high-energy ball mill (shaker mill). The effects of melinjo seed powders particle size on its physicochemical characteristics, extraction efficiency and release of phenolic compounds, as well as tyrosinase inhibitory activity were observed. The nanomilling successfully transformed melinjo seed micropowders into nanopowders within 90 min of milling. Particle size analysis showed that melinjo seed nanopowders were produced with a mean particle diameter of ~675 nm (PI 0.270). Scanning electron microscope (SEM) images of the melinjo seed nanopowders obviously showed a smaller particle size, a smooth surface, amorphous shapes and irregular edges. The melinjo seed nanopowders at mean particle diameter of ~675 nm exhibited the highest extraction yield and phenolic compounds release. As a consequence, the tyrosinase inhibitory activity of the melinjo seed nanopowders was 4.5 times higher than that of the melinjo seed micropowders. Based on the results obtained in this study, transformation of melinjo seed micropowders into nanopowders is very promising for improving the efficacy of melinjo seed as tyrosinase inhibitor. Penerbit Universiti Kebangsaan Malaysia 2019-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/13619/1/06%20Vienna%20Saraswaty.pdf Vienna Saraswaty, and Suparta, Ni Wayan Wulan Prawerti and Setiyanto, Henry and Rachmawati, Heni and Adnyana, I Ketut (2019) Transformation of Melinjo seed micropowders into nanopowders enhances extractability of phenolic compounds and tyrosinase inhibitory activity. Sains Malaysiana, 48 (5). pp. 983-990. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil5_2019/KandunganJilid48Bil5_2019.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Melinjo (Gnetum gnemon L.) seed powder extract exhibited antioxidant and tyrosinase inhibitory activity, thus showing potential as a dietary supplement or nutraceutical to prevent aging or hyperpigmentation. Previously, we found that particle size plays important role in extraction of bioactive compounds and influences their bioactivity. Thus, it is important to determine a certain particle size for the extraction process. In this study, we investigated the effects of transformation of melinjo seed micropowders into nanopowders by nanomilling using a high-energy ball mill (shaker mill). The effects of melinjo seed powders particle size on its physicochemical characteristics, extraction efficiency and release of phenolic compounds, as well as tyrosinase inhibitory activity were observed. The nanomilling successfully transformed melinjo seed micropowders into nanopowders within 90 min of milling. Particle size analysis showed that melinjo seed nanopowders were produced with a mean particle diameter of ~675 nm (PI 0.270). Scanning electron microscope (SEM) images of the melinjo seed nanopowders obviously showed a smaller particle size, a smooth surface, amorphous shapes and irregular edges. The melinjo seed nanopowders at mean particle diameter of ~675 nm exhibited the highest extraction yield and phenolic compounds release. As a consequence, the tyrosinase inhibitory activity of the melinjo seed nanopowders was 4.5 times higher than that of the melinjo seed micropowders. Based on the results obtained in this study, transformation of melinjo seed micropowders into nanopowders is very promising for improving the efficacy of melinjo seed as tyrosinase inhibitor.
format	Article
author	Vienna Saraswaty, Suparta, Ni Wayan Wulan Prawerti Setiyanto, Henry Rachmawati, Heni Adnyana, I Ketut
spellingShingle	Vienna Saraswaty, Suparta, Ni Wayan Wulan Prawerti Setiyanto, Henry Rachmawati, Heni Adnyana, I Ketut Transformation of Melinjo seed micropowders into nanopowders enhances extractability of phenolic compounds and tyrosinase inhibitory activity
author_facet	Vienna Saraswaty, Suparta, Ni Wayan Wulan Prawerti Setiyanto, Henry Rachmawati, Heni Adnyana, I Ketut
author_sort	Vienna Saraswaty,
title	Transformation of Melinjo seed micropowders into nanopowders enhances extractability of phenolic compounds and tyrosinase inhibitory activity
title_short	Transformation of Melinjo seed micropowders into nanopowders enhances extractability of phenolic compounds and tyrosinase inhibitory activity
title_full	Transformation of Melinjo seed micropowders into nanopowders enhances extractability of phenolic compounds and tyrosinase inhibitory activity
title_fullStr	Transformation of Melinjo seed micropowders into nanopowders enhances extractability of phenolic compounds and tyrosinase inhibitory activity
title_full_unstemmed	Transformation of Melinjo seed micropowders into nanopowders enhances extractability of phenolic compounds and tyrosinase inhibitory activity
title_sort	transformation of melinjo seed micropowders into nanopowders enhances extractability of phenolic compounds and tyrosinase inhibitory activity
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2019
url	http://journalarticle.ukm.my/13619/ http://journalarticle.ukm.my/13619/ http://journalarticle.ukm.my/13619/1/06%20Vienna%20Saraswaty.pdf
first_indexed	2023-09-18T20:05:15Z
last_indexed	2023-09-18T20:05:15Z
_version_	1777407115412897792

Transformation of Melinjo seed micropowders into nanopowders enhances extractability of phenolic compounds and tyrosinase inhibitory activity

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