Anti-urolithiatic effect of Pericampylus glaucus against ethylene glycol induced urolithiasis in male sprague dawley rats

Pericampylus glaucus is a common plant used traditionally for the remedies of urinary and kidney stones. Hence, present research was aimed to investigate the antiurolithiatic effect of ethanol extract of P. glaucus against ethylene glycol induced urolithiasis in male Sprague Dawley rats. The nephrol...

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Main Authors:	Kifayatullah, Muhammad, Rahim, Haroon, Jan, Naeem Ullah, Abbas, Sudhair, Khan, Muhammad Shahid, Ikram, Muhammad
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:	http://journalarticle.ukm.my/13629/ http://journalarticle.ukm.my/13629/ http://journalarticle.ukm.my/13629/1/16%20Muhammad%20Kifayatullah.pdf

id	ukm-13629
recordtype	eprints
spelling	ukm-136292019-11-10T03:40:50Z http://journalarticle.ukm.my/13629/ Anti-urolithiatic effect of Pericampylus glaucus against ethylene glycol induced urolithiasis in male sprague dawley rats Kifayatullah, Muhammad Rahim, Haroon Jan, Naeem Ullah Abbas, Sudhair Khan, Muhammad Shahid Ikram, Muhammad Pericampylus glaucus is a common plant used traditionally for the remedies of urinary and kidney stones. Hence, present research was aimed to investigate the antiurolithiatic effect of ethanol extract of P. glaucus against ethylene glycol induced urolithiasis in male Sprague Dawley rats. The nephrolithiasis was induced by ethylene glycol (0.75% v/v) in drinking water over a period of 30 days. The animals were divided into normal, lithiatic and extract treated group that received ethanolic extract of P. glaucus at dose rate of 200 and 400 mg/kg (b.wt) by mouth. The calcium, phosphate, urine pH, oxalate, magnesium in urine and histopathalogical examination of the kidney were observed. A significant (p<0.01) increased in the levels of phosphate, calcium, oxalate, and an imbalance in kidney with decreased magnesium excretion in urine were observed in ethylene glycol induced urolithiasis as compared to normal control. Treatment with ethanolic extract of P. glaucus at dose of 200 and 400 mg/kg (b.wt) decreased significantly (p<0.01) the hyperoxaluria, calcium, phosphate, oxalate with significant (p<0.05) increased retention of urinary magnesium and improvement in the renal function as matched to lithiatic group. The histopathological examination showed the deposition of a large number of calcium oxalate crystal in lithiatic group while smaller depositions in 200 mg/kg (b.wt) extract treated group. The results confirmed the antiurolithiatic effect of P. glaucus in male Sprague Dawley rats and validate its traditional uses against urinary stone. Penerbit Universiti Kebangsaan Malaysia 2019-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/13629/1/16%20Muhammad%20Kifayatullah.pdf Kifayatullah, Muhammad and Rahim, Haroon and Jan, Naeem Ullah and Abbas, Sudhair and Khan, Muhammad Shahid and Ikram, Muhammad (2019) Anti-urolithiatic effect of Pericampylus glaucus against ethylene glycol induced urolithiasis in male sprague dawley rats. Sains Malaysiana, 48 (5). pp. 1075-1081. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil5_2019/KandunganJilid48Bil5_2019.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Pericampylus glaucus is a common plant used traditionally for the remedies of urinary and kidney stones. Hence, present research was aimed to investigate the antiurolithiatic effect of ethanol extract of P. glaucus against ethylene glycol induced urolithiasis in male Sprague Dawley rats. The nephrolithiasis was induced by ethylene glycol (0.75% v/v) in drinking water over a period of 30 days. The animals were divided into normal, lithiatic and extract treated group that received ethanolic extract of P. glaucus at dose rate of 200 and 400 mg/kg (b.wt) by mouth. The calcium, phosphate, urine pH, oxalate, magnesium in urine and histopathalogical examination of the kidney were observed. A significant (p<0.01) increased in the levels of phosphate, calcium, oxalate, and an imbalance in kidney with decreased magnesium excretion in urine were observed in ethylene glycol induced urolithiasis as compared to normal control. Treatment with ethanolic extract of P. glaucus at dose of 200 and 400 mg/kg (b.wt) decreased significantly (p<0.01) the hyperoxaluria, calcium, phosphate, oxalate with significant (p<0.05) increased retention of urinary magnesium and improvement in the renal function as matched to lithiatic group. The histopathological examination showed the deposition of a large number of calcium oxalate crystal in lithiatic group while smaller depositions in 200 mg/kg (b.wt) extract treated group. The results confirmed the antiurolithiatic effect of P. glaucus in male Sprague Dawley rats and validate its traditional uses against urinary stone.
format	Article
author	Kifayatullah, Muhammad Rahim, Haroon Jan, Naeem Ullah Abbas, Sudhair Khan, Muhammad Shahid Ikram, Muhammad
spellingShingle	Kifayatullah, Muhammad Rahim, Haroon Jan, Naeem Ullah Abbas, Sudhair Khan, Muhammad Shahid Ikram, Muhammad Anti-urolithiatic effect of Pericampylus glaucus against ethylene glycol induced urolithiasis in male sprague dawley rats
author_facet	Kifayatullah, Muhammad Rahim, Haroon Jan, Naeem Ullah Abbas, Sudhair Khan, Muhammad Shahid Ikram, Muhammad
author_sort	Kifayatullah, Muhammad
title	Anti-urolithiatic effect of Pericampylus glaucus against ethylene glycol induced urolithiasis in male sprague dawley rats
title_short	Anti-urolithiatic effect of Pericampylus glaucus against ethylene glycol induced urolithiasis in male sprague dawley rats
title_full	Anti-urolithiatic effect of Pericampylus glaucus against ethylene glycol induced urolithiasis in male sprague dawley rats
title_fullStr	Anti-urolithiatic effect of Pericampylus glaucus against ethylene glycol induced urolithiasis in male sprague dawley rats
title_full_unstemmed	Anti-urolithiatic effect of Pericampylus glaucus against ethylene glycol induced urolithiasis in male sprague dawley rats
title_sort	anti-urolithiatic effect of pericampylus glaucus against ethylene glycol induced urolithiasis in male sprague dawley rats
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2019
url	http://journalarticle.ukm.my/13629/ http://journalarticle.ukm.my/13629/ http://journalarticle.ukm.my/13629/1/16%20Muhammad%20Kifayatullah.pdf
first_indexed	2023-09-18T20:05:17Z
last_indexed	2023-09-18T20:05:17Z
_version_	1777407116848398336

Anti-urolithiatic effect of Pericampylus glaucus against ethylene glycol induced urolithiasis in male sprague dawley rats

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