Effects of melamine and cyanuric acid on renal function and structure in rats

Melamine has been used to increase the amount of measurable nitrogen which is a component of protein. The renal toxicity of melamine has been reported in infants and animals that consumed a mixture of melamine in their food products. This study aimed to investigate the effects of melamine on rat ren...

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Main Authors:	Saranya Peerakietkhajorn, Nawiya Huipao, Siriphun Hiranyachattada
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:	http://journalarticle.ukm.my/13895/ http://journalarticle.ukm.my/13895/ http://journalarticle.ukm.my/13895/1/18%20Saranya%20Peerakietkhajorn.pdf

id	ukm-13895
recordtype	eprints
spelling	ukm-138952020-01-10T08:49:34Z http://journalarticle.ukm.my/13895/ Effects of melamine and cyanuric acid on renal function and structure in rats Saranya Peerakietkhajorn, Nawiya Huipao, Siriphun Hiranyachattada, Melamine has been used to increase the amount of measurable nitrogen which is a component of protein. The renal toxicity of melamine has been reported in infants and animals that consumed a mixture of melamine in their food products. This study aimed to investigate the effects of melamine on rat renal function using clearance and histological techniques. Animals were divided into 3 groups: vehicle control, 400 mg/kg melamine and mixture of 400 mg/kg melamine and 400 mg/kg cyanuric acid (p.o., daily for three days). The results showed that blood urea nitrogen level significantly increased in the rats treated with the mixture of melamine and cyanuric acid. The urine flow rate, glomerular filtration rate, renal plasma flow and urinary sodium and potassium excretion rate significantly decreased when compared to vehicle control. These results suggested both glomeruli and renal tubules of rats treated with mixture of melamine and cyanuric acid were damaged. Histological study also confirmed these findings and showed significant glomerular atrophy and dilated renal tubules. Numerous clear brownish-yellow crystals were also found in the distal tubule, collecting tubule and papillary duct. However, rats solely treated with melamine showed no significant difference in renal function or structures. Penerbit Universiti Kebangsaan Malaysia 2019-08 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/13895/1/18%20Saranya%20Peerakietkhajorn.pdf Saranya Peerakietkhajorn, and Nawiya Huipao, and Siriphun Hiranyachattada, (2019) Effects of melamine and cyanuric acid on renal function and structure in rats. Sains Malaysiana, 48 (8). pp. 1721-1728. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil8_2019/KandunganJilid48Bil8_2019.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Melamine has been used to increase the amount of measurable nitrogen which is a component of protein. The renal toxicity of melamine has been reported in infants and animals that consumed a mixture of melamine in their food products. This study aimed to investigate the effects of melamine on rat renal function using clearance and histological techniques. Animals were divided into 3 groups: vehicle control, 400 mg/kg melamine and mixture of 400 mg/kg melamine and 400 mg/kg cyanuric acid (p.o., daily for three days). The results showed that blood urea nitrogen level significantly increased in the rats treated with the mixture of melamine and cyanuric acid. The urine flow rate, glomerular filtration rate, renal plasma flow and urinary sodium and potassium excretion rate significantly decreased when compared to vehicle control. These results suggested both glomeruli and renal tubules of rats treated with mixture of melamine and cyanuric acid were damaged. Histological study also confirmed these findings and showed significant glomerular atrophy and dilated renal tubules. Numerous clear brownish-yellow crystals were also found in the distal tubule, collecting tubule and papillary duct. However, rats solely treated with melamine showed no significant difference in renal function or structures.
format	Article
author	Saranya Peerakietkhajorn, Nawiya Huipao, Siriphun Hiranyachattada,
spellingShingle	Saranya Peerakietkhajorn, Nawiya Huipao, Siriphun Hiranyachattada, Effects of melamine and cyanuric acid on renal function and structure in rats
author_facet	Saranya Peerakietkhajorn, Nawiya Huipao, Siriphun Hiranyachattada,
author_sort	Saranya Peerakietkhajorn,
title	Effects of melamine and cyanuric acid on renal function and structure in rats
title_short	Effects of melamine and cyanuric acid on renal function and structure in rats
title_full	Effects of melamine and cyanuric acid on renal function and structure in rats
title_fullStr	Effects of melamine and cyanuric acid on renal function and structure in rats
title_full_unstemmed	Effects of melamine and cyanuric acid on renal function and structure in rats
title_sort	effects of melamine and cyanuric acid on renal function and structure in rats
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2019
url	http://journalarticle.ukm.my/13895/ http://journalarticle.ukm.my/13895/ http://journalarticle.ukm.my/13895/1/18%20Saranya%20Peerakietkhajorn.pdf
first_indexed	2023-09-18T20:05:52Z
last_indexed	2023-09-18T20:05:52Z
_version_	1777407154188189696

Effects of melamine and cyanuric acid on renal function and structure in rats

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