Selenium and hepatocellular carcinoma
While cancer is considered to be one of the leading causes of death worldwide, there is a growing scientific and public interests on selenium as a dietary and antioxidant of many diseases, in particular, cancer. Despite advanced technology and significant improvement of surgical, chemical, hormon...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Penerbit UKM
2008
|
| Online Access: | http://journalarticle.ukm.my/1409/ http://journalarticle.ukm.my/1409/ http://journalarticle.ukm.my/1409/1/Chap%201.pdf |
| Summary: | While cancer is considered to be one of the leading causes of death worldwide,
there is a growing scientific and public interests on selenium as a dietary and
antioxidant of many diseases, in particular, cancer. Despite advanced
technology and significant improvement of surgical, chemical, hormonal and
radio therapies, hepatocellular carcinoma (HCC) is still common in Asia and
Africa and is increasing in the developed countries. Prognosis of HCC at an
early stage is still challenging. At the moment, combination of Alpha feto
protein (AFP) and ultrasonography tests offers more accurate and sensitive
results for the diagnosis of HCC. Selenium (also known as the moon element)
has been recognized for almost 49 years as an antioxidant and anti cancer
agent. The weight of evidence supports the position of selenium as an anti
cancer agent for HCC but the molecular mechanism of how selenium inhibits
HCC is still unknown. Numerous theories have been proposed and selenium
induced apoptosis and cell cycle arrest is the predominant one so far. |
|---|