The association between epstein-barr virus (EBV) past infection with the risk of oral squamous cell carcinoma (OSCC)

The association between epstein-barr virus (EBV) past infection with the risk of oral squamous cell carcinoma (OSCC)

The association of Epstein-Barr virus (EBV) with oral cancer has been widely reported in the past. However, previous studies mainly focused on the current infection of EBV without acknowledging the possibility of past infection in patients which may lead to oral cancer development. The present study...

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Main Authors: Jesinda P Kerishnan, Mah, Ming-Kit, Nurul Ain Mohd Fawzi, Anand Ramanathan, Lim, Ghee-Seong, Azwatee Abdul Aziz, Usharani Balasingam, Chen, Yeng
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:http://journalarticle.ukm.my/14351/
http://journalarticle.ukm.my/14351/
http://journalarticle.ukm.my/14351/1/18%20Jesinda%20P%20Kerishnan.pdf
id ukm-14351
recordtype eprints
spelling ukm-143512020-03-03T08:04:19Z http://journalarticle.ukm.my/14351/ The association between epstein-barr virus (EBV) past infection with the risk of oral squamous cell carcinoma (OSCC) Jesinda P Kerishnan, Mah, Ming-Kit Nurul Ain Mohd Fawzi, Anand Ramanathan, Lim, Ghee-Seong Azwatee Abdul Aziz, Usharani Balasingam, Chen, Yeng The association of Epstein-Barr virus (EBV) with oral cancer has been widely reported in the past. However, previous studies mainly focused on the current infection of EBV without acknowledging the possibility of past infection in patients which may lead to oral cancer development. The present study aims to investigate the correlation between past EBV infections with Oral Squamous Cell Carcinoma (OSCC). Both Immunoglobulin M (IgM) and Immunoglobulin G (IgG) antibodies against EBV were screened to detect the presence of EBV in sera of OSCC patients using Enzyme-Linked Immunosorbent Assay (ELISA). The use of IgM antibody against EBV confirms current infection in patients, whereas IgG antibody would predict past infection throughout patients’ lifetime. Through the present study, we would be able to confirm whether patients with past EBV infection have a significant risk in developing oral cancer. ELISA tests were carried out to detect the presence of EBV IgG and IgM in 206 OSCC and control serum samples. Statistical analysis was performed using SPSS 12.0.1. Our results had shown that 96.6% (n = 199) of OSCC samples and 97.2% (n = 130) control were positive with EBV VCA IgG, however, none of the OSCC and control samples was positive for EBV VCA IgM. The presence of EBV VCA IgG in both OSCC and control suggest that past EBV infection does not play a significant role as a risk indicator for OSCC. Therefore, the association between EBV and OSCC was not well demonstrated in this study. Penerbit Universiti Kebangsaan Malaysia 2019-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/14351/1/18%20Jesinda%20P%20Kerishnan.pdf Jesinda P Kerishnan, and Mah, Ming-Kit and Nurul Ain Mohd Fawzi, and Anand Ramanathan, and Lim, Ghee-Seong and Azwatee Abdul Aziz, and Usharani Balasingam, and Chen, Yeng (2019) The association between epstein-barr virus (EBV) past infection with the risk of oral squamous cell carcinoma (OSCC). Sains Malaysiana, 48 (9). pp. 1969-1974. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil9_2019/KandunganJilid48Bil9_2019.html
repository_type Digital Repository
institution_category Local University
institution Universiti Kebangasaan Malaysia
building UKM Institutional Repository
collection Online Access
language English
description The association of Epstein-Barr virus (EBV) with oral cancer has been widely reported in the past. However, previous studies mainly focused on the current infection of EBV without acknowledging the possibility of past infection in patients which may lead to oral cancer development. The present study aims to investigate the correlation between past EBV infections with Oral Squamous Cell Carcinoma (OSCC). Both Immunoglobulin M (IgM) and Immunoglobulin G (IgG) antibodies against EBV were screened to detect the presence of EBV in sera of OSCC patients using Enzyme-Linked Immunosorbent Assay (ELISA). The use of IgM antibody against EBV confirms current infection in patients, whereas IgG antibody would predict past infection throughout patients’ lifetime. Through the present study, we would be able to confirm whether patients with past EBV infection have a significant risk in developing oral cancer. ELISA tests were carried out to detect the presence of EBV IgG and IgM in 206 OSCC and control serum samples. Statistical analysis was performed using SPSS 12.0.1. Our results had shown that 96.6% (n = 199) of OSCC samples and 97.2% (n = 130) control were positive with EBV VCA IgG, however, none of the OSCC and control samples was positive for EBV VCA IgM. The presence of EBV VCA IgG in both OSCC and control suggest that past EBV infection does not play a significant role as a risk indicator for OSCC. Therefore, the association between EBV and OSCC was not well demonstrated in this study.
format Article
author Jesinda P Kerishnan,
Mah, Ming-Kit
Nurul Ain Mohd Fawzi,
Anand Ramanathan,
Lim, Ghee-Seong
Azwatee Abdul Aziz,
Usharani Balasingam,
Chen, Yeng
spellingShingle Jesinda P Kerishnan,
Mah, Ming-Kit
Nurul Ain Mohd Fawzi,
Anand Ramanathan,
Lim, Ghee-Seong
Azwatee Abdul Aziz,
Usharani Balasingam,
Chen, Yeng
The association between epstein-barr virus (EBV) past infection with the risk of oral squamous cell carcinoma (OSCC)
author_facet Jesinda P Kerishnan,
Mah, Ming-Kit
Nurul Ain Mohd Fawzi,
Anand Ramanathan,
Lim, Ghee-Seong
Azwatee Abdul Aziz,
Usharani Balasingam,
Chen, Yeng
author_sort Jesinda P Kerishnan,
title The association between epstein-barr virus (EBV) past infection with the risk of oral squamous cell carcinoma (OSCC)
title_short The association between epstein-barr virus (EBV) past infection with the risk of oral squamous cell carcinoma (OSCC)
title_full The association between epstein-barr virus (EBV) past infection with the risk of oral squamous cell carcinoma (OSCC)
title_fullStr The association between epstein-barr virus (EBV) past infection with the risk of oral squamous cell carcinoma (OSCC)
title_full_unstemmed The association between epstein-barr virus (EBV) past infection with the risk of oral squamous cell carcinoma (OSCC)
title_sort association between epstein-barr virus (ebv) past infection with the risk of oral squamous cell carcinoma (oscc)
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2019
url http://journalarticle.ukm.my/14351/
http://journalarticle.ukm.my/14351/
http://journalarticle.ukm.my/14351/1/18%20Jesinda%20P%20Kerishnan.pdf
first_indexed 2023-09-18T20:06:54Z
last_indexed 2023-09-18T20:06:54Z
_version_ 1777407218941952000

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