Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury

Multiple pathomechanisms of cerebral ischemia reperfusion (I/R) injuries can be ameliorated by certain high-potential pharmaceutical substances. In the present study, we investigated the acute effect of p-hydroxycinnamic (pHCA) acid against cerebral I/R injury in mice. Thirty male ICR mice were divi...

Full description

Bibliographic Details
Main Authors:	Romgase Sakamula, Chanikarn Sakdapitak, Wachiryah Thong-asa
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:	http://journalarticle.ukm.my/14401/ http://journalarticle.ukm.my/14401/ http://journalarticle.ukm.my/14401/1/18%20Romgase%20Sakamula.pdf

id	ukm-14401
recordtype	eprints
spelling	ukm-144012020-03-10T02:34:23Z http://journalarticle.ukm.my/14401/ Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury Romgase Sakamula, Chanikarn Sakdapitak, Wachiryah Thong-asa, Multiple pathomechanisms of cerebral ischemia reperfusion (I/R) injuries can be ameliorated by certain high-potential pharmaceutical substances. In the present study, we investigated the acute effect of p-hydroxycinnamic (pHCA) acid against cerebral I/R injury in mice. Thirty male ICR mice were divided into Sham, Control-I/R, and pHCA-I/R groups. The pHCA 100 mg/kg and the vehicle were given 30 min before I/R induction. Thirty-minute bilateral common carotid artery occlusion followed by 45-min reperfusion was performed on the Control-I/R and pHCA-I/R groups. Brains were collected for biochemical analysis, infarction and histological study of the cerebral cortex and corpus callosum (CC). The results showed that I/R induction significantly induced biochemical changes (p<0.05) along with the increase of brain infarction (p<0.05), percentage of degeneration in cerebral cortex (p<0.05) and decrease of CC white matter density (p<0.05). Pretreatment with pHCA significantly reduced MDA (p<0.05), brain infarction (p<0.05), cerebral cortex neuronal degeneration (p<0.05) and prevented the reduction of white matter density in the CC (p<0.05). The present study concluded that pretreatment with pHCA helps prevent cerebral I/R injury by amelioration of lipid peroxidation, white matter damage and neuronal degeneration. Penerbit Universiti Kebangsaan Malaysia 2019-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/14401/1/18%20Romgase%20Sakamula.pdf Romgase Sakamula, and Chanikarn Sakdapitak, and Wachiryah Thong-asa, (2019) Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury. Sains Malaysiana, 48 (10). pp. 2221-2227. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil10_2019/KandunganJilid48Bil10_2019.htm
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Multiple pathomechanisms of cerebral ischemia reperfusion (I/R) injuries can be ameliorated by certain high-potential pharmaceutical substances. In the present study, we investigated the acute effect of p-hydroxycinnamic (pHCA) acid against cerebral I/R injury in mice. Thirty male ICR mice were divided into Sham, Control-I/R, and pHCA-I/R groups. The pHCA 100 mg/kg and the vehicle were given 30 min before I/R induction. Thirty-minute bilateral common carotid artery occlusion followed by 45-min reperfusion was performed on the Control-I/R and pHCA-I/R groups. Brains were collected for biochemical analysis, infarction and histological study of the cerebral cortex and corpus callosum (CC). The results showed that I/R induction significantly induced biochemical changes (p<0.05) along with the increase of brain infarction (p<0.05), percentage of degeneration in cerebral cortex (p<0.05) and decrease of CC white matter density (p<0.05). Pretreatment with pHCA significantly reduced MDA (p<0.05), brain infarction (p<0.05), cerebral cortex neuronal degeneration (p<0.05) and prevented the reduction of white matter density in the CC (p<0.05). The present study concluded that pretreatment with pHCA helps prevent cerebral I/R injury by amelioration of lipid peroxidation, white matter damage and neuronal degeneration.
format	Article
author	Romgase Sakamula, Chanikarn Sakdapitak, Wachiryah Thong-asa,
spellingShingle	Romgase Sakamula, Chanikarn Sakdapitak, Wachiryah Thong-asa, Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury
author_facet	Romgase Sakamula, Chanikarn Sakdapitak, Wachiryah Thong-asa,
author_sort	Romgase Sakamula,
title	Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury
title_short	Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury
title_full	Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury
title_fullStr	Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury
title_full_unstemmed	Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury
title_sort	effect of p-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2019
url	http://journalarticle.ukm.my/14401/ http://journalarticle.ukm.my/14401/ http://journalarticle.ukm.my/14401/1/18%20Romgase%20Sakamula.pdf
first_indexed	2023-09-18T20:06:59Z
last_indexed	2023-09-18T20:06:59Z
_version_	1777407224569659392

Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury

Similar Items