Biphenotypic acute leukemia: a report of two cases

We report two cases of biphenotypic acute leukaemia diagnosed in Hospital Universiti Kebangsaan Malaysia (HUKM), their clinical, haematological characteristics and response to chemotherapy. Both patients are middle-aged ladies who presented with hepatosplenomegaly and high white cell count, mainly c...

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Main Authors:	RZ Azma, NH Hamidah, C-F Leong, Fadilah SAW, O Ainoon, Salwati S, S-K Cheong, Sharifah N A
Format:	Article
Language:	English
Published:	Penerbit UKM 2006
Online Access:	http://journalarticle.ukm.my/1886/ http://journalarticle.ukm.my/1886/ http://journalarticle.ukm.my/1886/1/09._53-60_%28MH_016%29.pdf

id	ukm-1886
recordtype	eprints
spelling	ukm-18862016-12-14T06:30:22Z http://journalarticle.ukm.my/1886/ Biphenotypic acute leukemia: a report of two cases RZ Azma, NH Hamidah, C-F Leong, Fadilah SAW, O Ainoon, Salwati S, S-K Cheong, Sharifah N A, We report two cases of biphenotypic acute leukaemia diagnosed in Hospital Universiti Kebangsaan Malaysia (HUKM), their clinical, haematological characteristics and response to chemotherapy. Both patients are middle-aged ladies who presented with hepatosplenomegaly and high white cell count, mainly composed of blast cells. Their bone marrow aspirations were hypercellular comprising of more than 90% heterogenous blast cells. Cytochemical analyses show more than 3% positivity towards peroxidase, with smaller blasts showing block positivity towards PAS. Immunophenotypically, the blasts showed dual expression of CD 33 and CD 19, CD 19 and CD34, intra CD22, intra TdT and intraMPO. One of the patients showed presence of the Philadelphia chromosome on cytogenetic analysis which was confirmed by Fluorecsence In Situ Hybridisation (FISH). Molecular analysis also showed presence of the BCR-ABL fusion protein. Both patients were given combination chemotherapy consisting of daunorubicin and cytosine arabinoside.However, the patient with positive Philadelphia chromosome BCR-ABL did not achieve morphological remission after induction chemotherapy. In view of the poor prognosis of this disease, both the patients were planned for upfront peripheral blood stem cell transplantation Penerbit UKM 2006 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/1886/1/09._53-60_%28MH_016%29.pdf RZ Azma, and NH Hamidah, and C-F Leong, and Fadilah SAW, and O Ainoon, and Salwati S, and S-K Cheong, and Sharifah N A, (2006) Biphenotypic acute leukemia: a report of two cases. Medicine & Health, 1 (1). http://www.ppukm.ukm.my/ukmmcjournal/index.php
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	We report two cases of biphenotypic acute leukaemia diagnosed in Hospital Universiti Kebangsaan Malaysia (HUKM), their clinical, haematological characteristics and response to chemotherapy. Both patients are middle-aged ladies who presented with hepatosplenomegaly and high white cell count, mainly composed of blast cells. Their bone marrow aspirations were hypercellular comprising of more than 90% heterogenous blast cells. Cytochemical analyses show more than 3% positivity towards peroxidase, with smaller blasts showing block positivity towards PAS. Immunophenotypically, the blasts showed dual expression of CD 33 and CD 19, CD 19 and CD34, intra CD22, intra TdT and intraMPO. One of the patients showed presence of the Philadelphia chromosome on cytogenetic analysis which was confirmed by Fluorecsence In Situ Hybridisation (FISH). Molecular analysis also showed presence of the BCR-ABL fusion protein. Both patients were given combination chemotherapy consisting of daunorubicin and cytosine arabinoside.However, the patient with positive Philadelphia chromosome BCR-ABL did not achieve morphological remission after induction chemotherapy. In view of the poor prognosis of this disease, both the patients were planned for upfront peripheral blood stem cell transplantation
format	Article
author	RZ Azma, NH Hamidah, C-F Leong, Fadilah SAW, O Ainoon, Salwati S, S-K Cheong, Sharifah N A,
spellingShingle	RZ Azma, NH Hamidah, C-F Leong, Fadilah SAW, O Ainoon, Salwati S, S-K Cheong, Sharifah N A, Biphenotypic acute leukemia: a report of two cases
author_facet	RZ Azma, NH Hamidah, C-F Leong, Fadilah SAW, O Ainoon, Salwati S, S-K Cheong, Sharifah N A,
author_sort	RZ Azma,
title	Biphenotypic acute leukemia: a report of two cases
title_short	Biphenotypic acute leukemia: a report of two cases
title_full	Biphenotypic acute leukemia: a report of two cases
title_fullStr	Biphenotypic acute leukemia: a report of two cases
title_full_unstemmed	Biphenotypic acute leukemia: a report of two cases
title_sort	biphenotypic acute leukemia: a report of two cases
publisher	Penerbit UKM
publishDate	2006
url	http://journalarticle.ukm.my/1886/ http://journalarticle.ukm.my/1886/ http://journalarticle.ukm.my/1886/1/09._53-60_%28MH_016%29.pdf
first_indexed	2023-09-18T19:34:38Z
last_indexed	2023-09-18T19:34:38Z
_version_	1777405188468899840

Biphenotypic acute leukemia: a report of two cases

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