Langerhans cell sarcoma – a rare tumour diagnosed by histomorphology and immunophenotyping

Langerhans cell sarcoma is a rare neoplastic proliferation of Langerhans cells that has overt malignant cytologic features. It behaves more aggressively than its counterpart, Langerhans cell histiocytosis. We present here a case of Langerhans cell sarcoma involving the eighth thoracic vertebra in a...

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Main Authors:	Maraei Awadh BM, Elnasri MA, Tan SP, Noraidah M
Format:	Article
Language:	English
Published:	Penerbit UKM 2009
Online Access:	http://journalarticle.ukm.my/1950/ http://journalarticle.ukm.my/1950/ http://journalarticle.ukm.my/1950/1/04-4%282%29_~_MS_085_%2864-75%29.pdf

id	ukm-1950
recordtype	eprints
spelling	ukm-19502016-12-14T06:30:31Z http://journalarticle.ukm.my/1950/ Langerhans cell sarcoma – a rare tumour diagnosed by histomorphology and immunophenotyping Maraei Awadh BM, Elnasri MA, Tan SP, Noraidah M, Langerhans cell sarcoma is a rare neoplastic proliferation of Langerhans cells that has overt malignant cytologic features. It behaves more aggressively than its counterpart, Langerhans cell histiocytosis. We present here a case of Langerhans cell sarcoma involving the eighth thoracic vertebra in a 31-yr-old man who presented with a two-month history of back pain. In the past, the diagnosis of Langerhans cell sarcoma relied on the demonstration of Birbeck granules. However, with the advent of monoclonal antibodies suitable on routinely-fixed tissues, the Langerhans cell phenotype can be easily confirmed by CD1a protein expression using immunohistochemistry. In this report, we describe the morphological features and the immunohistochemical findings of this tumour diagnosed even in the absence of Birbeck granules. We also highlighted how immunophenotyping is useful in differentiating Langerhans cell sarcoma from other histiocytic and dendritic tumours. Penerbit UKM 2009 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/1950/1/04-4%282%29_~_MS_085_%2864-75%29.pdf Maraei Awadh BM, and Elnasri MA, and Tan SP, and Noraidah M, (2009) Langerhans cell sarcoma – a rare tumour diagnosed by histomorphology and immunophenotyping. Medicine & Health, 4 (2). pp. 122-126. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Langerhans cell sarcoma is a rare neoplastic proliferation of Langerhans cells that has overt malignant cytologic features. It behaves more aggressively than its counterpart, Langerhans cell histiocytosis. We present here a case of Langerhans cell sarcoma involving the eighth thoracic vertebra in a 31-yr-old man who presented with a two-month history of back pain. In the past, the diagnosis of Langerhans cell sarcoma relied on the demonstration of Birbeck granules. However, with the advent of monoclonal antibodies suitable on routinely-fixed tissues, the Langerhans cell phenotype can be easily confirmed by CD1a protein expression using immunohistochemistry. In this report, we describe the morphological features and the immunohistochemical findings of this tumour diagnosed even in the absence of Birbeck granules. We also highlighted how immunophenotyping is useful in differentiating Langerhans cell sarcoma from other histiocytic and dendritic tumours.
format	Article
author	Maraei Awadh BM, Elnasri MA, Tan SP, Noraidah M,
spellingShingle	Maraei Awadh BM, Elnasri MA, Tan SP, Noraidah M, Langerhans cell sarcoma – a rare tumour diagnosed by histomorphology and immunophenotyping
author_facet	Maraei Awadh BM, Elnasri MA, Tan SP, Noraidah M,
author_sort	Maraei Awadh BM,
title	Langerhans cell sarcoma – a rare tumour diagnosed by histomorphology and immunophenotyping
title_short	Langerhans cell sarcoma – a rare tumour diagnosed by histomorphology and immunophenotyping
title_full	Langerhans cell sarcoma – a rare tumour diagnosed by histomorphology and immunophenotyping
title_fullStr	Langerhans cell sarcoma – a rare tumour diagnosed by histomorphology and immunophenotyping
title_full_unstemmed	Langerhans cell sarcoma – a rare tumour diagnosed by histomorphology and immunophenotyping
title_sort	langerhans cell sarcoma – a rare tumour diagnosed by histomorphology and immunophenotyping
publisher	Penerbit UKM
publishDate	2009
url	http://journalarticle.ukm.my/1950/ http://journalarticle.ukm.my/1950/ http://journalarticle.ukm.my/1950/1/04-4%282%29_~_MS_085_%2864-75%29.pdf
first_indexed	2023-09-18T19:34:46Z
last_indexed	2023-09-18T19:34:46Z
_version_	1777405197632405504

Langerhans cell sarcoma – a rare tumour diagnosed by histomorphology and immunophenotyping

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