Metaplastic breast carcinomas: a report of six cases

Metaplastic breast carcinomas (MBCs) are rare primary breast malignancies characterized histologically by carcinoma of two epithelial types or co-existence of carcinoma with non-epithelial cellular elements. They are aggressive tumours that carry poor prognosis. We reviewed the pathologic features a...

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Main Authors:	Shahrun NS, Rohaizak M, Naqiyah I, Nurismah MI
Format:	Article
Language:	English
Published:	Penerbit UKM 2009
Online Access:	http://journalarticle.ukm.my/1951/ http://journalarticle.ukm.my/1951/ http://journalarticle.ukm.my/1951/1/04-4%282%29_~_MS_085_%2864-75%29.pdf

id	ukm-1951
recordtype	eprints
spelling	ukm-19512016-12-14T06:30:31Z http://journalarticle.ukm.my/1951/ Metaplastic breast carcinomas: a report of six cases Shahrun NS, Rohaizak M, Naqiyah I, Nurismah MI, Metaplastic breast carcinomas (MBCs) are rare primary breast malignancies characterized histologically by carcinoma of two epithelial types or co-existence of carcinoma with non-epithelial cellular elements. They are aggressive tumours that carry poor prognosis. We reviewed the pathologic features and clinical outcomes of MBCs seen in our institution between the years 2000 to 2007. Out of 471 breast cancer patients, six female patients were histologically-proven to have MBCs giving an incidence rate of 1.3%. The patients comprised four Malays and two Indians and their mean age was 51 years old. Five patients underwent mastectomy (four with axillary clearance and one without) and one had wide local excision with axillary clearance. Axillary lymph node involvement was seen in four patients (three with epithelial only type tumour and one with the biphasic tumour). In all the cases, the tumours were bigger than 5 cm in diameter (T3), grade 3 and estrogen receptor negative. Five patients received chemotherapy while one refused. All of the patients had tumour recurrence with a mean time of recurrence of 9 months. In conclusion, metaplastic breast carcinomas are rare and aggressive tumours usually affect the post menopausal age group. They present as aggressive, large sized, high grade tumours that are estrogen receptor negative. Tumour size and axillary lymph node involvement indicate poor prognosis. Despite treatment with chemotherapy and radiotherapy, these patients have high risk of local recurrence and distant metastases which are potentially fatal. Penerbit UKM 2009 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/1951/1/04-4%282%29_~_MS_085_%2864-75%29.pdf Shahrun NS, and Rohaizak M, and Naqiyah I, and Nurismah MI, (2009) Metaplastic breast carcinomas: a report of six cases. Medicine & Health, 4 (2). pp. 127-132. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Metaplastic breast carcinomas (MBCs) are rare primary breast malignancies characterized histologically by carcinoma of two epithelial types or co-existence of carcinoma with non-epithelial cellular elements. They are aggressive tumours that carry poor prognosis. We reviewed the pathologic features and clinical outcomes of MBCs seen in our institution between the years 2000 to 2007. Out of 471 breast cancer patients, six female patients were histologically-proven to have MBCs giving an incidence rate of 1.3%. The patients comprised four Malays and two Indians and their mean age was 51 years old. Five patients underwent mastectomy (four with axillary clearance and one without) and one had wide local excision with axillary clearance. Axillary lymph node involvement was seen in four patients (three with epithelial only type tumour and one with the biphasic tumour). In all the cases, the tumours were bigger than 5 cm in diameter (T3), grade 3 and estrogen receptor negative. Five patients received chemotherapy while one refused. All of the patients had tumour recurrence with a mean time of recurrence of 9 months. In conclusion, metaplastic breast carcinomas are rare and aggressive tumours usually affect the post menopausal age group. They present as aggressive, large sized, high grade tumours that are estrogen receptor negative. Tumour size and axillary lymph node involvement indicate poor prognosis. Despite treatment with chemotherapy and radiotherapy, these patients have high risk of local recurrence and distant metastases which are potentially fatal.
format	Article
author	Shahrun NS, Rohaizak M, Naqiyah I, Nurismah MI,
spellingShingle	Shahrun NS, Rohaizak M, Naqiyah I, Nurismah MI, Metaplastic breast carcinomas: a report of six cases
author_facet	Shahrun NS, Rohaizak M, Naqiyah I, Nurismah MI,
author_sort	Shahrun NS,
title	Metaplastic breast carcinomas: a report of six cases
title_short	Metaplastic breast carcinomas: a report of six cases
title_full	Metaplastic breast carcinomas: a report of six cases
title_fullStr	Metaplastic breast carcinomas: a report of six cases
title_full_unstemmed	Metaplastic breast carcinomas: a report of six cases
title_sort	metaplastic breast carcinomas: a report of six cases
publisher	Penerbit UKM
publishDate	2009
url	http://journalarticle.ukm.my/1951/ http://journalarticle.ukm.my/1951/ http://journalarticle.ukm.my/1951/1/04-4%282%29_~_MS_085_%2864-75%29.pdf
first_indexed	2023-09-18T19:34:46Z
last_indexed	2023-09-18T19:34:46Z
_version_	1777405197772914688

Metaplastic breast carcinomas: a report of six cases

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