Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report

Anaplastic large cell lymphoma (ALCL) is a rare tumour, accounting for approximately 3% of adult non-Hodgkin lymphomas.1 Primary systemic ALCL frequently involves both lymph nodes and extranodal sites. A 44-year-old woman presented with a firm, mobile mass in the left iliac fossa region. Ultrasou...

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Main Authors:	Siti-Aishah M.A., Salwati S, Idrus M., Rahimah R., Salmi A., Leong C.F., Sharifah N.A
Format:	Article
Language:	English
Published:	Penerbit UKM 2008
Online Access:	http://journalarticle.ukm.my/2021/ http://journalarticle.ukm.my/2021/ http://journalarticle.ukm.my/2021/1/Page_69_-_74.pdf

id	ukm-2021
recordtype	eprints
spelling	ukm-20212016-12-14T06:30:41Z http://journalarticle.ukm.my/2021/ Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report Siti-Aishah M.A., Salwati S,, Idrus M., Rahimah R., Salmi A., Leong C.F., Sharifah N.A, Anaplastic large cell lymphoma (ALCL) is a rare tumour, accounting for approximately 3% of adult non-Hodgkin lymphomas.1 Primary systemic ALCL frequently involves both lymph nodes and extranodal sites. A 44-year-old woman presented with a firm, mobile mass in the left iliac fossa region. Ultrasound findings showed a well defined inhomogenous soft tissue mass, measuring 4x4x2.6cm in the deep subcutaneous region. Histopathological examination revealed that the mass was infiltrated by large lymphoid cells with marked nuclear atypia including kidney-shaped nuclei. These neoplastic cells expressed anaplastic lymphoma kinase (ALK) (both nuclear & cytoplasmic staining), CD30 and EMA but not for T-cell (CD45RO and CD3), and B-cell (CD20 & CD79α) markers. Fluorescence in situ hybridization (FISH) analysis showed a t(2;5)(p23;q35) chromosomal translocation. Subsequently the patient developed shortness of the breath and a thoracic computed tomography (CT) scan showed a mass encasing the right upper lobe bronchus. She also had bilateral axillary lymph nodes, measuring 1 cm in diameter (biopsy was not done). The mediastinum and endobronchial region did not show any abnormalities. She received 6 cycles of CHOP chemotherapy and remained disease free 2 years after diagnosis. ALCL, rarely present as a soft tissue tumour and this disease should be included as a differential diagnosis of any soft tissue mass Penerbit UKM 2008 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2021/1/Page_69_-_74.pdf Siti-Aishah M.A., and Salwati S,, and Idrus M., and Rahimah R., and Salmi A., and Leong C.F., and Sharifah N.A, (2008) Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report. Medicine & Health, 3 (1). pp. 69-74. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Anaplastic large cell lymphoma (ALCL) is a rare tumour, accounting for approximately 3% of adult non-Hodgkin lymphomas.1 Primary systemic ALCL frequently involves both lymph nodes and extranodal sites. A 44-year-old woman presented with a firm, mobile mass in the left iliac fossa region. Ultrasound findings showed a well defined inhomogenous soft tissue mass, measuring 4x4x2.6cm in the deep subcutaneous region. Histopathological examination revealed that the mass was infiltrated by large lymphoid cells with marked nuclear atypia including kidney-shaped nuclei. These neoplastic cells expressed anaplastic lymphoma kinase (ALK) (both nuclear & cytoplasmic staining), CD30 and EMA but not for T-cell (CD45RO and CD3), and B-cell (CD20 & CD79α) markers. Fluorescence in situ hybridization (FISH) analysis showed a t(2;5)(p23;q35) chromosomal translocation. Subsequently the patient developed shortness of the breath and a thoracic computed tomography (CT) scan showed a mass encasing the right upper lobe bronchus. She also had bilateral axillary lymph nodes, measuring 1 cm in diameter (biopsy was not done). The mediastinum and endobronchial region did not show any abnormalities. She received 6 cycles of CHOP chemotherapy and remained disease free 2 years after diagnosis. ALCL, rarely present as a soft tissue tumour and this disease should be included as a differential diagnosis of any soft tissue mass
format	Article
author	Siti-Aishah M.A., Salwati S,, Idrus M., Rahimah R., Salmi A., Leong C.F., Sharifah N.A,
spellingShingle	Siti-Aishah M.A., Salwati S,, Idrus M., Rahimah R., Salmi A., Leong C.F., Sharifah N.A, Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report
author_facet	Siti-Aishah M.A., Salwati S,, Idrus M., Rahimah R., Salmi A., Leong C.F., Sharifah N.A,
author_sort	Siti-Aishah M.A.,
title	Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report
title_short	Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report
title_full	Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report
title_fullStr	Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report
title_full_unstemmed	Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report
title_sort	anaplastic large cell lymphoma presenting as a soft tissue mass – a case report
publisher	Penerbit UKM
publishDate	2008
url	http://journalarticle.ukm.my/2021/ http://journalarticle.ukm.my/2021/ http://journalarticle.ukm.my/2021/1/Page_69_-_74.pdf
first_indexed	2023-09-18T19:34:59Z
last_indexed	2023-09-18T19:34:59Z
_version_	1777405210417692672

Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report

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