Effects of pink guava (Psidium guajava) puree supplementation on antioxidant enzyme activities and organ functions of spontaneous hypertensive rat

This study was aimed to determine the effects of pink guava (Psidium guajava) puree supplementation on enzyme activities, kidney and liver function tests of Spontaneous Hypertensive Rats (SHR). Twenty-four male SHR were divided into four groups (control, CG (distilled water); low dosage group, LDG (...

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Main Authors:	Norazmir Md Nor, Ayub Mohd Yatim
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2011
Online Access:	http://journalarticle.ukm.my/2402/ http://journalarticle.ukm.my/2402/ http://journalarticle.ukm.my/2402/1/13_Norazmir.pdf

id	ukm-2402
recordtype	eprints
spelling	ukm-24022016-12-14T06:31:30Z http://journalarticle.ukm.my/2402/ Effects of pink guava (Psidium guajava) puree supplementation on antioxidant enzyme activities and organ functions of spontaneous hypertensive rat Norazmir Md Nor, Ayub Mohd Yatim, This study was aimed to determine the effects of pink guava (Psidium guajava) puree supplementation on enzyme activities, kidney and liver function tests of Spontaneous Hypertensive Rats (SHR). Twenty-four male SHR were divided into four groups (control, CG (distilled water); low dosage group, LDG (0.5 g/kg body weight); medium dosage group, MDG (1.0 g/kg body weight); high dosage group, HDG (2.0g/kg body weight)). The rats were given pink guava puree via force-feeding and fed rat pellets ad libitum for 28 days in individual cages at 25±2°C. At the end of experiment, the rats were fast overnight (12 to14 h) and euthanized under an anesthetic condition with ether, and blood was collected from the portal vein or posterior vena cava. The specific activities of glutathione peroxidase (GPx) was significantly higher in LDG (2332.5±81.8 U/L), MDG (2424.8±97.1 U/L) and HDG (2594.6±82.8 U/L) respectively, as compared to CG (2171.8±65.9 U/L). Significant differences were also seen in glutathione reductase (GR) activities among all treated groups (LDG (132.5±11.8 U/L), MDG (141.5±16.4 U/L), HDG (148.8±13.2 U/L) compared to CG (126.1±14.2 U/L)). Liver function tests for total antioxidant status (TAS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and γ-glutamyl transpeptidase (GGT) showed significant differences in the treated group compared to control group. In conclusion, this study shows pink guava puree supplementation increase antioxidant enzyme activity in SHR’s blood concentration. Universiti Kebangsaan Malaysia 2011-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2402/1/13_Norazmir.pdf Norazmir Md Nor, and Ayub Mohd Yatim, (2011) Effects of pink guava (Psidium guajava) puree supplementation on antioxidant enzyme activities and organ functions of spontaneous hypertensive rat. Sains Malaysiana, 40 (4). pp. 369-372. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	This study was aimed to determine the effects of pink guava (Psidium guajava) puree supplementation on enzyme activities, kidney and liver function tests of Spontaneous Hypertensive Rats (SHR). Twenty-four male SHR were divided into four groups (control, CG (distilled water); low dosage group, LDG (0.5 g/kg body weight); medium dosage group, MDG (1.0 g/kg body weight); high dosage group, HDG (2.0g/kg body weight)). The rats were given pink guava puree via force-feeding and fed rat pellets ad libitum for 28 days in individual cages at 25±2°C. At the end of experiment, the rats were fast overnight (12 to14 h) and euthanized under an anesthetic condition with ether, and blood was collected from the portal vein or posterior vena cava. The specific activities of glutathione peroxidase (GPx) was significantly higher in LDG (2332.5±81.8 U/L), MDG (2424.8±97.1 U/L) and HDG (2594.6±82.8 U/L) respectively, as compared to CG (2171.8±65.9 U/L). Significant differences were also seen in glutathione reductase (GR) activities among all treated groups (LDG (132.5±11.8 U/L), MDG (141.5±16.4 U/L), HDG (148.8±13.2 U/L) compared to CG (126.1±14.2 U/L)). Liver function tests for total antioxidant status (TAS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and γ-glutamyl transpeptidase (GGT) showed significant differences in the treated group compared to control group. In conclusion, this study shows pink guava puree supplementation increase antioxidant enzyme activity in SHR’s blood concentration.
format	Article
author	Norazmir Md Nor, Ayub Mohd Yatim,
spellingShingle	Norazmir Md Nor, Ayub Mohd Yatim, Effects of pink guava (Psidium guajava) puree supplementation on antioxidant enzyme activities and organ functions of spontaneous hypertensive rat
author_facet	Norazmir Md Nor, Ayub Mohd Yatim,
author_sort	Norazmir Md Nor,
title	Effects of pink guava (Psidium guajava) puree supplementation on antioxidant enzyme activities and organ functions of spontaneous hypertensive rat
title_short	Effects of pink guava (Psidium guajava) puree supplementation on antioxidant enzyme activities and organ functions of spontaneous hypertensive rat
title_full	Effects of pink guava (Psidium guajava) puree supplementation on antioxidant enzyme activities and organ functions of spontaneous hypertensive rat
title_fullStr	Effects of pink guava (Psidium guajava) puree supplementation on antioxidant enzyme activities and organ functions of spontaneous hypertensive rat
title_full_unstemmed	Effects of pink guava (Psidium guajava) puree supplementation on antioxidant enzyme activities and organ functions of spontaneous hypertensive rat
title_sort	effects of pink guava (psidium guajava) puree supplementation on antioxidant enzyme activities and organ functions of spontaneous hypertensive rat
publisher	Universiti Kebangsaan Malaysia
publishDate	2011
url	http://journalarticle.ukm.my/2402/ http://journalarticle.ukm.my/2402/ http://journalarticle.ukm.my/2402/1/13_Norazmir.pdf
first_indexed	2023-09-18T19:36:00Z
last_indexed	2023-09-18T19:36:00Z
_version_	1777405274787676160

Effects of pink guava (Psidium guajava) puree supplementation on antioxidant enzyme activities and organ functions of spontaneous hypertensive rat

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