Synthesis and antimicrobial activity of 1-(5-Mercapto-1,3,4-Oxadiazol-2-yl) -2-(Pyridine-2-ylamino)ethanone

1-(5-Mercapto-1,3,4-oxadiazol-2-yl)-2-(pyridine-2-ylamino)ethanone (3), has been synthesized from 2-(pyridine-2-ylamino)acetohydrazide (2). A yellow colored compound (2) was reacted with carbon disulfide and potassium hydroxide in absolute ethanol to obtain the 1-(5-mercapto-1,3,4-oxadiazol-2-yl)-2-...

Full description

Bibliographic Details
Main Authors:	Jumat Salimon, Nadia Salih, Hasan Hussien
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2011
Online Access:	http://journalarticle.ukm.my/2481/ http://journalarticle.ukm.my/2481/ http://journalarticle.ukm.my/2481/1/06_Jumat_Salimon.pdf

id	ukm-2481
recordtype	eprints
spelling	ukm-24812016-12-14T06:31:45Z http://journalarticle.ukm.my/2481/ Synthesis and antimicrobial activity of 1-(5-Mercapto-1,3,4-Oxadiazol-2-yl) -2-(Pyridine-2-ylamino)ethanone Jumat Salimon, Nadia Salih, Hasan Hussien, 1-(5-Mercapto-1,3,4-oxadiazol-2-yl)-2-(pyridine-2-ylamino)ethanone (3), has been synthesized from 2-(pyridine-2-ylamino)acetohydrazide (2). A yellow colored compound (2) was reacted with carbon disulfide and potassium hydroxide in absolute ethanol to obtain the 1-(5-mercapto-1,3,4-oxadiazol-2-yl)-2-(pyridine-2-ylamino)ethanone. Structures of the synthesized compounds were supported by means of IR, NMR, MS spectroscopic and elemental analysis. The synthesized compounds were evaluated for their antimicrobial activity and were expressed as the corresponding minimum inhibitory concentration (MIC). A brown colored compound (3) with 90% yield has been successfully synthesized. This compound was found to have significant antimicrobial activity with MIC value ranging from 30.2 - 43.2 μg cm-3. The findings of the present study indicate that cyclization of hydrazide acid group of 2-(pyridine-2-ylamino)acetohydrazide (2) into 1,3,4-oxadiazole nucleus resulted in increased antimicrobial activity. Universiti Kebangsaan Malaysia 2011-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2481/1/06_Jumat_Salimon.pdf Jumat Salimon, and Nadia Salih, and Hasan Hussien, (2011) Synthesis and antimicrobial activity of 1-(5-Mercapto-1,3,4-Oxadiazol-2-yl) -2-(Pyridine-2-ylamino)ethanone. Sains Malaysiana, 40 (5). pp. 445-450. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	1-(5-Mercapto-1,3,4-oxadiazol-2-yl)-2-(pyridine-2-ylamino)ethanone (3), has been synthesized from 2-(pyridine-2-ylamino)acetohydrazide (2). A yellow colored compound (2) was reacted with carbon disulfide and potassium hydroxide in absolute ethanol to obtain the 1-(5-mercapto-1,3,4-oxadiazol-2-yl)-2-(pyridine-2-ylamino)ethanone. Structures of the synthesized compounds were supported by means of IR, NMR, MS spectroscopic and elemental analysis. The synthesized compounds were evaluated for their antimicrobial activity and were expressed as the corresponding minimum inhibitory concentration (MIC). A brown colored compound (3) with 90% yield has been successfully synthesized. This compound was found to have significant antimicrobial activity with MIC value ranging from 30.2 - 43.2 μg cm-3. The findings of the present study indicate that cyclization of hydrazide acid group of 2-(pyridine-2-ylamino)acetohydrazide (2) into 1,3,4-oxadiazole nucleus resulted in increased antimicrobial activity.
format	Article
author	Jumat Salimon, Nadia Salih, Hasan Hussien,
spellingShingle	Jumat Salimon, Nadia Salih, Hasan Hussien, Synthesis and antimicrobial activity of 1-(5-Mercapto-1,3,4-Oxadiazol-2-yl) -2-(Pyridine-2-ylamino)ethanone
author_facet	Jumat Salimon, Nadia Salih, Hasan Hussien,
author_sort	Jumat Salimon,
title	Synthesis and antimicrobial activity of 1-(5-Mercapto-1,3,4-Oxadiazol-2-yl) -2-(Pyridine-2-ylamino)ethanone
title_short	Synthesis and antimicrobial activity of 1-(5-Mercapto-1,3,4-Oxadiazol-2-yl) -2-(Pyridine-2-ylamino)ethanone
title_full	Synthesis and antimicrobial activity of 1-(5-Mercapto-1,3,4-Oxadiazol-2-yl) -2-(Pyridine-2-ylamino)ethanone
title_fullStr	Synthesis and antimicrobial activity of 1-(5-Mercapto-1,3,4-Oxadiazol-2-yl) -2-(Pyridine-2-ylamino)ethanone
title_full_unstemmed	Synthesis and antimicrobial activity of 1-(5-Mercapto-1,3,4-Oxadiazol-2-yl) -2-(Pyridine-2-ylamino)ethanone
title_sort	synthesis and antimicrobial activity of 1-(5-mercapto-1,3,4-oxadiazol-2-yl) -2-(pyridine-2-ylamino)ethanone
publisher	Universiti Kebangsaan Malaysia
publishDate	2011
url	http://journalarticle.ukm.my/2481/ http://journalarticle.ukm.my/2481/ http://journalarticle.ukm.my/2481/1/06_Jumat_Salimon.pdf
first_indexed	2023-09-18T19:36:13Z
last_indexed	2023-09-18T19:36:13Z
_version_	1777405288245100544

Synthesis and antimicrobial activity of 1-(5-Mercapto-1,3,4-Oxadiazol-2-yl) -2-(Pyridine-2-ylamino)ethanone

Similar Items