Survivin expression in uterine cervical exfoliative cells as diagnostic test of cervical malignancy process

Papanicolaou test is a diagnostic test for uterine cervical cancer screening and routinely examined. It has limitations. A better technique is needed to identify true cervical malignancy process. Molecular cancer marker detection may have high the sensitivity and specificity in detecting cancer. Sur...

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Main Authors:	Zulham, Ahmad Aulia Jusuf, Junita Indarti, Lisnawati
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2011
Online Access:	http://journalarticle.ukm.my/2486/ http://journalarticle.ukm.my/2486/ http://journalarticle.ukm.my/2486/1/10_Zulham.pdf

id	ukm-2486
recordtype	eprints
spelling	ukm-24862016-12-14T06:31:46Z http://journalarticle.ukm.my/2486/ Survivin expression in uterine cervical exfoliative cells as diagnostic test of cervical malignancy process Zulham, Ahmad Aulia Jusuf, Junita Indarti, Lisnawati, Papanicolaou test is a diagnostic test for uterine cervical cancer screening and routinely examined. It has limitations. A better technique is needed to identify true cervical malignancy process. Molecular cancer marker detection may have high the sensitivity and specificity in detecting cancer. Survivin, a marker candidate, is upregulated in many malignancy processes. Ninety women have joined in this cross sectional study by consecutive sampling. Survivin expression was examined by indirect immunoperoxidase method. It was predominantly found in metaplastic cells. Correlation between survivin expression and Papanicolaou test results was calculated by Fischer’s-exact test. Using Papanicolaou test result as an indicator for the presence of uterine cervical abnormalities, the performance indicators were calculated. Fischer’s-exact test showed that survivin expression was not significantly useful as cervical cancer molecular marker. Survivin expression of the uterine cervical exfoliative cells cannot be used as a diagnostic test for uterine cervical malignancy process. Universiti Kebangsaan Malaysia 2011-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2486/1/10_Zulham.pdf Zulham, and Ahmad Aulia Jusuf, and Junita Indarti, and Lisnawati, (2011) Survivin expression in uterine cervical exfoliative cells as diagnostic test of cervical malignancy process. Sains Malaysiana, 40 (5). pp. 475-479. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Papanicolaou test is a diagnostic test for uterine cervical cancer screening and routinely examined. It has limitations. A better technique is needed to identify true cervical malignancy process. Molecular cancer marker detection may have high the sensitivity and specificity in detecting cancer. Survivin, a marker candidate, is upregulated in many malignancy processes. Ninety women have joined in this cross sectional study by consecutive sampling. Survivin expression was examined by indirect immunoperoxidase method. It was predominantly found in metaplastic cells. Correlation between survivin expression and Papanicolaou test results was calculated by Fischer’s-exact test. Using Papanicolaou test result as an indicator for the presence of uterine cervical abnormalities, the performance indicators were calculated. Fischer’s-exact test showed that survivin expression was not significantly useful as cervical cancer molecular marker. Survivin expression of the uterine cervical exfoliative cells cannot be used as a diagnostic test for uterine cervical malignancy process.
format	Article
author	Zulham, Ahmad Aulia Jusuf, Junita Indarti, Lisnawati,
spellingShingle	Zulham, Ahmad Aulia Jusuf, Junita Indarti, Lisnawati, Survivin expression in uterine cervical exfoliative cells as diagnostic test of cervical malignancy process
author_facet	Zulham, Ahmad Aulia Jusuf, Junita Indarti, Lisnawati,
author_sort	Zulham,
title	Survivin expression in uterine cervical exfoliative cells as diagnostic test of cervical malignancy process
title_short	Survivin expression in uterine cervical exfoliative cells as diagnostic test of cervical malignancy process
title_full	Survivin expression in uterine cervical exfoliative cells as diagnostic test of cervical malignancy process
title_fullStr	Survivin expression in uterine cervical exfoliative cells as diagnostic test of cervical malignancy process
title_full_unstemmed	Survivin expression in uterine cervical exfoliative cells as diagnostic test of cervical malignancy process
title_sort	survivin expression in uterine cervical exfoliative cells as diagnostic test of cervical malignancy process
publisher	Universiti Kebangsaan Malaysia
publishDate	2011
url	http://journalarticle.ukm.my/2486/ http://journalarticle.ukm.my/2486/ http://journalarticle.ukm.my/2486/1/10_Zulham.pdf
first_indexed	2023-09-18T19:36:13Z
last_indexed	2023-09-18T19:36:13Z
_version_	1777405288989589504

Survivin expression in uterine cervical exfoliative cells as diagnostic test of cervical malignancy process

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