Antihyperglycemic activity of F. deltoidea ethanolic extract in normal rats

Ficus deltoidea is one of the common medicinal plants used in Malaysia. This epiphytic plant, from the Moraceae family has been claimed to have antidiabetic property. However, scientific evidence to confirm its efficacy is still lacking. The present study was undertaken to evaluate the effect of eth...

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Main Authors:	Zainah Adam, Amin Ismail, Shafii Khamis, Muhammad Hanaffi Mohd. Mokhtar, Muhajir Hamid
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2011
Online Access:	http://journalarticle.ukm.my/2488/ http://journalarticle.ukm.my/2488/ http://journalarticle.ukm.my/2488/1/12_Zainah.pdf

id	ukm-2488
recordtype	eprints
spelling	ukm-24882016-12-14T06:31:46Z http://journalarticle.ukm.my/2488/ Antihyperglycemic activity of F. deltoidea ethanolic extract in normal rats Zainah Adam, Amin Ismail, Shafii Khamis, Muhammad Hanaffi Mohd. Mokhtar, Muhajir Hamid, Ficus deltoidea is one of the common medicinal plants used in Malaysia. This epiphytic plant, from the Moraceae family has been claimed to have antidiabetic property. However, scientific evidence to confirm its efficacy is still lacking. The present study was undertaken to evaluate the effect of ethanolic extract of F. deltoidea on glucose level in normal rats at different prandial state. The results showed that, all doses of ethanolic extract of F. deltoidea reduced fasting blood glucose particularly after 6 h of administration. Interestingly, the extract did not produce severe hypoglycemia as shown by its comparable effect with metformin. Likewise, postprandial hyperglycemia was also significantly reduced particularly after 4 and 6 h of administration. Furthermore, extract was used at a dose of 1000 mg/kg b.w., reduced postprandial hyperglycemia similar to metformin. This suggests that postprandial antihyperglycemic mechanism of this extract is mediated through enhancement of glucose uptake into muscle cells and reduction of hepatic gluconeogenesis. Glucose tolerance activity was also significantly improved in the presence of ethanolic extract of F. deltoidea. From this study, it is suggested that ethanolic extract of F. deltoidea reduced postprandial hyperglycemia and improves glucose tolerance activity in normal rats. Universiti Kebangsaan Malaysia 2011-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2488/1/12_Zainah.pdf Zainah Adam, and Amin Ismail, and Shafii Khamis, and Muhammad Hanaffi Mohd. Mokhtar, and Muhajir Hamid, (2011) Antihyperglycemic activity of F. deltoidea ethanolic extract in normal rats. Sains Malaysiana, 40 (5). pp. 489-495. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Ficus deltoidea is one of the common medicinal plants used in Malaysia. This epiphytic plant, from the Moraceae family has been claimed to have antidiabetic property. However, scientific evidence to confirm its efficacy is still lacking. The present study was undertaken to evaluate the effect of ethanolic extract of F. deltoidea on glucose level in normal rats at different prandial state. The results showed that, all doses of ethanolic extract of F. deltoidea reduced fasting blood glucose particularly after 6 h of administration. Interestingly, the extract did not produce severe hypoglycemia as shown by its comparable effect with metformin. Likewise, postprandial hyperglycemia was also significantly reduced particularly after 4 and 6 h of administration. Furthermore, extract was used at a dose of 1000 mg/kg b.w., reduced postprandial hyperglycemia similar to metformin. This suggests that postprandial antihyperglycemic mechanism of this extract is mediated through enhancement of glucose uptake into muscle cells and reduction of hepatic gluconeogenesis. Glucose tolerance activity was also significantly improved in the presence of ethanolic extract of F. deltoidea. From this study, it is suggested that ethanolic extract of F. deltoidea reduced postprandial hyperglycemia and improves glucose tolerance activity in normal rats.
format	Article
author	Zainah Adam, Amin Ismail, Shafii Khamis, Muhammad Hanaffi Mohd. Mokhtar, Muhajir Hamid,
spellingShingle	Zainah Adam, Amin Ismail, Shafii Khamis, Muhammad Hanaffi Mohd. Mokhtar, Muhajir Hamid, Antihyperglycemic activity of F. deltoidea ethanolic extract in normal rats
author_facet	Zainah Adam, Amin Ismail, Shafii Khamis, Muhammad Hanaffi Mohd. Mokhtar, Muhajir Hamid,
author_sort	Zainah Adam,
title	Antihyperglycemic activity of F. deltoidea ethanolic extract in normal rats
title_short	Antihyperglycemic activity of F. deltoidea ethanolic extract in normal rats
title_full	Antihyperglycemic activity of F. deltoidea ethanolic extract in normal rats
title_fullStr	Antihyperglycemic activity of F. deltoidea ethanolic extract in normal rats
title_full_unstemmed	Antihyperglycemic activity of F. deltoidea ethanolic extract in normal rats
title_sort	antihyperglycemic activity of f. deltoidea ethanolic extract in normal rats
publisher	Universiti Kebangsaan Malaysia
publishDate	2011
url	http://journalarticle.ukm.my/2488/ http://journalarticle.ukm.my/2488/ http://journalarticle.ukm.my/2488/1/12_Zainah.pdf
first_indexed	2023-09-18T19:36:14Z
last_indexed	2023-09-18T19:36:14Z
_version_	1777405289302065152

Antihyperglycemic activity of F. deltoidea ethanolic extract in normal rats

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