Altered levels of serum haptoglobin and apo A-I in schizophrenia

Schizophrenia is a debilitating psychiatric syndrome that affects 1% of the world’s population. Abnormalities in immune functions and role of inflammatory markers have been widely described in schizophrenia. With the alarming high prevalence, this study aims to investigate the association of acute p...

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Main Authors:	Tze Jen Chow, Han Chern Loh
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2011
Online Access:	http://journalarticle.ukm.my/2946/ http://journalarticle.ukm.my/2946/ http://journalarticle.ukm.my/2946/1/18_Tze_Jen_Chow.pdf

id	ukm-2946
recordtype	eprints
spelling	ukm-29462016-12-14T06:33:08Z http://journalarticle.ukm.my/2946/ Altered levels of serum haptoglobin and apo A-I in schizophrenia Tze Jen Chow, Han Chern Loh, Schizophrenia is a debilitating psychiatric syndrome that affects 1% of the world’s population. Abnormalities in immune functions and role of inflammatory markers have been widely described in schizophrenia. With the alarming high prevalence, this study aims to investigate the association of acute phase proteins with schizophrenia. We investigated the serum proteome of 20 schizophrenic patients and 20 healthy controls using two-dimensional gel electrophoresis and mass spectrometry. The spots were analysed using Image Master 2D Platinum software. In total, we have detected 774 protein spots in human serum and found that three of them showed altered changes in schizophrenic patients, as compared to healthy controls. Among these acute phase proteins, haptoglobin (p = 0.003) and two isoforms of apolipoprotein A-I (p = 0.004, p = 0.003) were found to be significantly decreased in patients, as compared to controls. Our findings support the hypothesis that inflammatory response system is linked to the pathophysiology of schizophrenia. Universiti Kebangsaan Malaysia 2011-11 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2946/1/18_Tze_Jen_Chow.pdf Tze Jen Chow, and Han Chern Loh, (2011) Altered levels of serum haptoglobin and apo A-I in schizophrenia. Sains Malaysiana, 40 (11). pp. 1319-1323. ISSN 0126-6039 http://www.ukm.my/jsm/contents.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Schizophrenia is a debilitating psychiatric syndrome that affects 1% of the world’s population. Abnormalities in immune functions and role of inflammatory markers have been widely described in schizophrenia. With the alarming high prevalence, this study aims to investigate the association of acute phase proteins with schizophrenia. We investigated the serum proteome of 20 schizophrenic patients and 20 healthy controls using two-dimensional gel electrophoresis and mass spectrometry. The spots were analysed using Image Master 2D Platinum software. In total, we have detected 774 protein spots in human serum and found that three of them showed altered changes in schizophrenic patients, as compared to healthy controls. Among these acute phase proteins, haptoglobin (p = 0.003) and two isoforms of apolipoprotein A-I (p = 0.004, p = 0.003) were found to be significantly decreased in patients, as compared to controls. Our findings support the hypothesis that inflammatory response system is linked to the pathophysiology of schizophrenia.
format	Article
author	Tze Jen Chow, Han Chern Loh,
spellingShingle	Tze Jen Chow, Han Chern Loh, Altered levels of serum haptoglobin and apo A-I in schizophrenia
author_facet	Tze Jen Chow, Han Chern Loh,
author_sort	Tze Jen Chow,
title	Altered levels of serum haptoglobin and apo A-I in schizophrenia
title_short	Altered levels of serum haptoglobin and apo A-I in schizophrenia
title_full	Altered levels of serum haptoglobin and apo A-I in schizophrenia
title_fullStr	Altered levels of serum haptoglobin and apo A-I in schizophrenia
title_full_unstemmed	Altered levels of serum haptoglobin and apo A-I in schizophrenia
title_sort	altered levels of serum haptoglobin and apo a-i in schizophrenia
publisher	Universiti Kebangsaan Malaysia
publishDate	2011
url	http://journalarticle.ukm.my/2946/ http://journalarticle.ukm.my/2946/ http://journalarticle.ukm.my/2946/1/18_Tze_Jen_Chow.pdf
first_indexed	2023-09-18T19:37:25Z
last_indexed	2023-09-18T19:37:25Z
_version_	1777405364439875584

Altered levels of serum haptoglobin and apo A-I in schizophrenia

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