Survival difference between surgery versus non-surgery for the treatment of hepatocellular carcinoma patients at Liver Centre, Malaysia

Hepatic resection, the only treatment that offers long term survival for patients with Hepatocellular carcinoma (HCC), have shown significant improvement in results over the past decades. The aim of the study was to compare the survival between patients receiving and not receiving surgery. A retrosp...

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Main Authors:	Azmawati MN, Azmi MT, Krishnan R
Format:	Article
Language:	English
Published:	Department of Surgery, UKM Medical Centre 2011
Online Access:	http://journalarticle.ukm.my/2957/ http://journalarticle.ukm.my/2957/ http://journalarticle.ukm.my/2957/1/10-18.pdf

id	ukm-2957
recordtype	eprints
spelling	ukm-29572016-12-14T06:33:10Z http://journalarticle.ukm.my/2957/ Survival difference between surgery versus non-surgery for the treatment of hepatocellular carcinoma patients at Liver Centre, Malaysia Azmawati MN, Azmi MT, Krishnan R, Hepatic resection, the only treatment that offers long term survival for patients with Hepatocellular carcinoma (HCC), have shown significant improvement in results over the past decades. The aim of the study was to compare the survival between patients receiving and not receiving surgery. A retrospective co¬hort study measured the survival of newly diagnosed cases of HCC patients who underwent treatment in Selayang Hospital from 1 January 2003 till 31 December 2006. Survival time was measured from the date of diagnosis until the subjects died or until the end of study period (31 December 2007). Overall survival was significantly longer in surgery group in comparison with non-surgery group with a median survival of 43 and 20 months, respectively (p<0.001). The following factors were noted to have improved survival duration with surgical resection; Child Pugh Class B patients, tumor size less or more than 4cm and number of nodules less than 3. Sub¬group analysis showed improved survival duration with surgical resection among patients with Child Pugh Class B with tumor size less than 4cm or with nodule less than 3 and patients who had less than 3 nodules, even with tumor size of less or more than 4cm. Multivariate Cox Re¬gression showed surgical intervention significantly improved survival time for overall patients (Adjusted HR: 1.5) while non-surgery improved survival in patients with tumor size less than 4cm (Adjusted HR: 0.4). Surgical resection significantly improved the survival duration in over¬all patients while non-surgical procedure improved survival if the tumor size was less than 4cm. Department of Surgery, UKM Medical Centre 2011-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2957/1/10-18.pdf Azmawati MN, and Azmi MT, and Krishnan R, (2011) Survival difference between surgery versus non-surgery for the treatment of hepatocellular carcinoma patients at Liver Centre, Malaysia. Journal of Surgical Academia, 1 (2). pp. 10-18. ISSN 2231-7481 http://jsurgacad.com/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Hepatic resection, the only treatment that offers long term survival for patients with Hepatocellular carcinoma (HCC), have shown significant improvement in results over the past decades. The aim of the study was to compare the survival between patients receiving and not receiving surgery. A retrospective co¬hort study measured the survival of newly diagnosed cases of HCC patients who underwent treatment in Selayang Hospital from 1 January 2003 till 31 December 2006. Survival time was measured from the date of diagnosis until the subjects died or until the end of study period (31 December 2007). Overall survival was significantly longer in surgery group in comparison with non-surgery group with a median survival of 43 and 20 months, respectively (p<0.001). The following factors were noted to have improved survival duration with surgical resection; Child Pugh Class B patients, tumor size less or more than 4cm and number of nodules less than 3. Sub¬group analysis showed improved survival duration with surgical resection among patients with Child Pugh Class B with tumor size less than 4cm or with nodule less than 3 and patients who had less than 3 nodules, even with tumor size of less or more than 4cm. Multivariate Cox Re¬gression showed surgical intervention significantly improved survival time for overall patients (Adjusted HR: 1.5) while non-surgery improved survival in patients with tumor size less than 4cm (Adjusted HR: 0.4). Surgical resection significantly improved the survival duration in over¬all patients while non-surgical procedure improved survival if the tumor size was less than 4cm.
format	Article
author	Azmawati MN, Azmi MT, Krishnan R,
spellingShingle	Azmawati MN, Azmi MT, Krishnan R, Survival difference between surgery versus non-surgery for the treatment of hepatocellular carcinoma patients at Liver Centre, Malaysia
author_facet	Azmawati MN, Azmi MT, Krishnan R,
author_sort	Azmawati MN,
title	Survival difference between surgery versus non-surgery for the treatment of hepatocellular carcinoma patients at Liver Centre, Malaysia
title_short	Survival difference between surgery versus non-surgery for the treatment of hepatocellular carcinoma patients at Liver Centre, Malaysia
title_full	Survival difference between surgery versus non-surgery for the treatment of hepatocellular carcinoma patients at Liver Centre, Malaysia
title_fullStr	Survival difference between surgery versus non-surgery for the treatment of hepatocellular carcinoma patients at Liver Centre, Malaysia
title_full_unstemmed	Survival difference between surgery versus non-surgery for the treatment of hepatocellular carcinoma patients at Liver Centre, Malaysia
title_sort	survival difference between surgery versus non-surgery for the treatment of hepatocellular carcinoma patients at liver centre, malaysia
publisher	Department of Surgery, UKM Medical Centre
publishDate	2011
url	http://journalarticle.ukm.my/2957/ http://journalarticle.ukm.my/2957/ http://journalarticle.ukm.my/2957/1/10-18.pdf
first_indexed	2023-09-18T19:37:27Z
last_indexed	2023-09-18T19:37:27Z
_version_	1777405365833433088

Survival difference between surgery versus non-surgery for the treatment of hepatocellular carcinoma patients at Liver Centre, Malaysia

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