Control of adipose tissue lipoprotein lipase expression by isoproterenol

Isoproterenol decreased adipose tissue lipoprotein lipase (LPL) activity during in vitro incubation and the decrease was dose-dependent. The activity was reduced to 54.5% of the control (P<0.001) by 10 µM isoproterenol after 2h incubation. Isoproterenol did not alter general protein synthesis, LP...

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Main Author:	Halimah Abdullah Sani
Format:	Article
Published:	Universiti Kebangsaan Malaysia 1996
Online Access:	http://journalarticle.ukm.my/3724/ http://journalarticle.ukm.my/3724/

id	ukm-3724
recordtype	eprints
spelling	ukm-37242012-03-16T02:53:58Z http://journalarticle.ukm.my/3724/ Control of adipose tissue lipoprotein lipase expression by isoproterenol Halimah Abdullah Sani, Isoproterenol decreased adipose tissue lipoprotein lipase (LPL) activity during in vitro incubation and the decrease was dose-dependent. The activity was reduced to 54.5% of the control (P<0.001) by 10 µM isoproterenol after 2h incubation. Isoproterenol did not alter general protein synthesis, LPL synthesis or relative LPL synthesis. It has no significant effect on general protein degradation but significantly increased LPL degradation. The percentage of LPL degradation was increase from 39.8% in the absence to 54.2% in the presence of 10 µM isoproterenol. The level of LPL mRNA as well as the ratio of LPL mRNA/α-tubulin mRNA were significantly decreased by 23% (P<0.05) during 2h incubation at 32°C. These results show that the control of adipose tissue LPL expression by isoproterenol occurred at the level of transcription and posttranslation. Universiti Kebangsaan Malaysia 1996-12 Article PeerReviewed Halimah Abdullah Sani, (1996) Control of adipose tissue lipoprotein lipase expression by isoproterenol. Sains Malaysiana, 25 (4). pp. 123-130. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol25num4_1996/vol25num4_96page123-130.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
description	Isoproterenol decreased adipose tissue lipoprotein lipase (LPL) activity during in vitro incubation and the decrease was dose-dependent. The activity was reduced to 54.5% of the control (P<0.001) by 10 µM isoproterenol after 2h incubation. Isoproterenol did not alter general protein synthesis, LPL synthesis or relative LPL synthesis. It has no significant effect on general protein degradation but significantly increased LPL degradation. The percentage of LPL degradation was increase from 39.8% in the absence to 54.2% in the presence of 10 µM isoproterenol. The level of LPL mRNA as well as the ratio of LPL mRNA/α-tubulin mRNA were significantly decreased by 23% (P<0.05) during 2h incubation at 32°C. These results show that the control of adipose tissue LPL expression by isoproterenol occurred at the level of transcription and posttranslation.
format	Article
author	Halimah Abdullah Sani,
spellingShingle	Halimah Abdullah Sani, Control of adipose tissue lipoprotein lipase expression by isoproterenol
author_facet	Halimah Abdullah Sani,
author_sort	Halimah Abdullah Sani,
title	Control of adipose tissue lipoprotein lipase expression by isoproterenol
title_short	Control of adipose tissue lipoprotein lipase expression by isoproterenol
title_full	Control of adipose tissue lipoprotein lipase expression by isoproterenol
title_fullStr	Control of adipose tissue lipoprotein lipase expression by isoproterenol
title_full_unstemmed	Control of adipose tissue lipoprotein lipase expression by isoproterenol
title_sort	control of adipose tissue lipoprotein lipase expression by isoproterenol
publisher	Universiti Kebangsaan Malaysia
publishDate	1996
url	http://journalarticle.ukm.my/3724/ http://journalarticle.ukm.my/3724/
first_indexed	2023-09-18T19:39:36Z
last_indexed	2023-09-18T19:39:36Z
_version_	1777405500897361920

Control of adipose tissue lipoprotein lipase expression by isoproterenol

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