DNA repair at the gene level in trichothiodystrophy cells

Cells from trichothiodystrophy (TTD) group 3 patients are non-hypersensitive to uv irradiation. These cells perform normal genome repair of pyrimidine dimers but fail to excise 6-4 photoproducts and concomitantly, are unable to restore RNA synthesis levels following uv irradiation. This pointed to a...

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Main Authors:	Nathan , Sheila, Mayne, Lynne
Format:	Article
Published:	Universiti Kebangsaan Malaysia 2000
Online Access:	http://journalarticle.ukm.my/3779/ http://journalarticle.ukm.my/3779/

id	ukm-3779
recordtype	eprints
spelling	ukm-37792012-03-20T01:56:29Z http://journalarticle.ukm.my/3779/ DNA repair at the gene level in trichothiodystrophy cells Nathan , Sheila Mayne, Lynne Cells from trichothiodystrophy (TTD) group 3 patients are non-hypersensitive to uv irradiation. These cells perform normal genome repair of pyrimidine dimers but fail to excise 6-4 photoproducts and concomitantly, are unable to restore RNA synthesis levels following uv irradiation. This pointed to a defect in gene-specific repair and this study was undertaken to examine repair of dimers at the gene-level. The results indicated a defect in gene-specific repair of dimers at early times post-irradiation due to the inability of the cells to repair dimers from the transcribed strand of the active gene. These findings indicate that TTD group 3 cells are unable to remove DNA lesions preferentially and this might contribute to other inherent symptoms of these patients. Universiti Kebangsaan Malaysia 2000 Article PeerReviewed Nathan , Sheila and Mayne, Lynne (2000) DNA repair at the gene level in trichothiodystrophy cells. Sains Malaysiana, 29 . pp. 19-31. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol29_2000/vol29_00page19-31.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
description	Cells from trichothiodystrophy (TTD) group 3 patients are non-hypersensitive to uv irradiation. These cells perform normal genome repair of pyrimidine dimers but fail to excise 6-4 photoproducts and concomitantly, are unable to restore RNA synthesis levels following uv irradiation. This pointed to a defect in gene-specific repair and this study was undertaken to examine repair of dimers at the gene-level. The results indicated a defect in gene-specific repair of dimers at early times post-irradiation due to the inability of the cells to repair dimers from the transcribed strand of the active gene. These findings indicate that TTD group 3 cells are unable to remove DNA lesions preferentially and this might contribute to other inherent symptoms of these patients.
format	Article
author	Nathan , Sheila Mayne, Lynne
spellingShingle	Nathan , Sheila Mayne, Lynne DNA repair at the gene level in trichothiodystrophy cells
author_facet	Nathan , Sheila Mayne, Lynne
author_sort	Nathan , Sheila
title	DNA repair at the gene level in trichothiodystrophy cells
title_short	DNA repair at the gene level in trichothiodystrophy cells
title_full	DNA repair at the gene level in trichothiodystrophy cells
title_fullStr	DNA repair at the gene level in trichothiodystrophy cells
title_full_unstemmed	DNA repair at the gene level in trichothiodystrophy cells
title_sort	dna repair at the gene level in trichothiodystrophy cells
publisher	Universiti Kebangsaan Malaysia
publishDate	2000
url	http://journalarticle.ukm.my/3779/ http://journalarticle.ukm.my/3779/
first_indexed	2023-09-18T19:39:43Z
last_indexed	2023-09-18T19:39:43Z
_version_	1777405508765876224

DNA repair at the gene level in trichothiodystrophy cells

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