Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats

Curcuma longa or turmeric has long been used in traditional medicine by the local population in Malaysia as an antiinflammatory agent. It has been proven to contain natural antiarthritic compound called curcumin. Joints abnormality and destruction have been implicated in the pathogenesis of rheumato...

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Main Authors: Zahidah, A.F, Faizah, O, Nur Aqilah, K, Taty Anna, K
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2012
Online Access:http://journalarticle.ukm.my/4472/
http://journalarticle.ukm.my/4472/
http://journalarticle.ukm.my/4472/1/10%2520Zahidah.pdf
id ukm-4472
recordtype eprints
spelling ukm-44722016-12-14T06:36:07Z http://journalarticle.ukm.my/4472/ Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats Zahidah, A.F Faizah, O Nur Aqilah, K Taty Anna, K Curcuma longa or turmeric has long been used in traditional medicine by the local population in Malaysia as an antiinflammatory agent. It has been proven to contain natural antiarthritic compound called curcumin. Joints abnormality and destruction have been implicated in the pathogenesis of rheumatoid arthritis (RA) due to inflammatory reactions. In this study, collagen-induced arthritis (CIA) model was utilized to study the effects of curcumin on joint inflammation in Sprague-Dawley rats. Body weight measurement, arthritis score assessment and radiology score assessment were carried out at specific intervals throughout this study. The results showed that the mean arthritis and radiology scores for animal groups designated as CIA CurcuminC and CIA CurcuminT were significantly lower compared with the negative control (CIA OV) group respectively. The mean arthritis scores for CIA CurcuminC group is significantly lower compared with CIA CurcuminT group but there is no significant difference in the mean radiology scores between the CIA CurcuminC and CIA CurcuminT groups. In conclusion, the oral supplementation of curcumin at the dose of 110 mg/mL/kg/day has a potential to delay and improve joint abnormality and injury in Sprague-Dawley rats with CIA. Universiti Kebangsaan Malaysia 2012-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/4472/1/10%2520Zahidah.pdf Zahidah, A.F and Faizah, O and Nur Aqilah, K and Taty Anna, K (2012) Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats. Sains Malaysiana, 41 (5). pp. 591-595. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type Digital Repository
institution_category Local University
institution Universiti Kebangasaan Malaysia
building UKM Institutional Repository
collection Online Access
language English
description Curcuma longa or turmeric has long been used in traditional medicine by the local population in Malaysia as an antiinflammatory agent. It has been proven to contain natural antiarthritic compound called curcumin. Joints abnormality and destruction have been implicated in the pathogenesis of rheumatoid arthritis (RA) due to inflammatory reactions. In this study, collagen-induced arthritis (CIA) model was utilized to study the effects of curcumin on joint inflammation in Sprague-Dawley rats. Body weight measurement, arthritis score assessment and radiology score assessment were carried out at specific intervals throughout this study. The results showed that the mean arthritis and radiology scores for animal groups designated as CIA CurcuminC and CIA CurcuminT were significantly lower compared with the negative control (CIA OV) group respectively. The mean arthritis scores for CIA CurcuminC group is significantly lower compared with CIA CurcuminT group but there is no significant difference in the mean radiology scores between the CIA CurcuminC and CIA CurcuminT groups. In conclusion, the oral supplementation of curcumin at the dose of 110 mg/mL/kg/day has a potential to delay and improve joint abnormality and injury in Sprague-Dawley rats with CIA.
format Article
author Zahidah, A.F
Faizah, O
Nur Aqilah, K
Taty Anna, K
spellingShingle Zahidah, A.F
Faizah, O
Nur Aqilah, K
Taty Anna, K
Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
author_facet Zahidah, A.F
Faizah, O
Nur Aqilah, K
Taty Anna, K
author_sort Zahidah, A.F
title Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
title_short Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
title_full Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
title_fullStr Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
title_full_unstemmed Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
title_sort curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
publisher Universiti Kebangsaan Malaysia
publishDate 2012
url http://journalarticle.ukm.my/4472/
http://journalarticle.ukm.my/4472/
http://journalarticle.ukm.my/4472/1/10%2520Zahidah.pdf
first_indexed 2023-09-18T19:41:38Z
last_indexed 2023-09-18T19:41:38Z
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