Neurobehavioral test performances in lead exposed in lead exposed workers, 1996

Neurobehavioral test performances in lead exposed in lead exposed workers, 1996

Neurobehavioral test has been used extensively and successfully in many countries to determine neurotoxic effects of various compounds. To determine neurotoxic effects of lead, a cross sectional studies was conducted on 141 male workers from two local battery manufacturing factories using' Neur...

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Main Authors: Mazrura Sahani, Noor Hassim Ismail
Format: Article
Language:English
Published: Department Of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia 2006
Online Access:http://journalarticle.ukm.my/4520/
http://journalarticle.ukm.my/4520/
http://journalarticle.ukm.my/4520/1/Vol12%281%29-Rizal.pdf
id ukm-4520
recordtype eprints
spelling ukm-45202016-12-14T06:36:15Z http://journalarticle.ukm.my/4520/ Neurobehavioral test performances in lead exposed in lead exposed workers, 1996 Mazrura Sahani, Noor Hassim Ismail, Neurobehavioral test has been used extensively and successfully in many countries to determine neurotoxic effects of various compounds. To determine neurotoxic effects of lead, a cross sectional studies was conducted on 141 male workers from two local battery manufacturing factories using' Neurobehavioral Core Test Batteries' ( NCTB) from' World Health Organisation'. These NCTB consist of several tests which can highlight various neuropsychological functions and a list of questionnaire for subjective symptoms. The workers, were divided into two groups based on their blood lead levels ( PbB ), the first group for those with PbB < 40 µg/dl with mean PbB 27.19 ± 10.23 and the second group with PbB > 40 µg/dl with mean PbB 53.10 ± 11.13. Student t-test has shown significant different between the two groups in neurobehavioral test performance such as Digit Symbol ( p= 0.02 ), Digit Backward ( p=0.01 ), Santa Ana preferred hand ( p=0.04 ), Santa Ana both hands ( p=0.02 ), Aiming Pursuit Test ( p=0.0002) and Trail B ( p= 0.0004 ). Workers from the second group also reported higher subjective symptoms of weakness in lower limbs and anorexia. Factors which have influenced on PbB were jobs category ( p=0.0001 ), work duration (p=0.04 ), chemical exposure ( p= 0.04 ), previous lead exposure ( p= 0.01 ) and usage of personal protective device ( p= 0.04 ). Significant correlation was found between PbB and neurobehavioral test performance such as Digit Symbol ( r= -0.04348 ), Digit Forward ( r= -0.2107 ), Digit Backward ( r= - 0.0003 ), Aiming Pursuit Test .( r= -0.2476 ) and Trail B ( r='0.3040 ). Regression analysis has shown reduction in cognitive and concentration functions with PbB level less that 30 µg/dl and maximum lead effect at Digit Symbol's score of 40. This study has shown that lead has led to impairment of cognitive, concentration, memory and motor steadiness functions and has proven the ability of neurobehavioral test in detecting lead toxicity at low levels. Department Of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia 2006 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/4520/1/Vol12%281%29-Rizal.pdf Mazrura Sahani, and Noor Hassim Ismail, (2006) Neurobehavioral test performances in lead exposed in lead exposed workers, 1996. Jurnal Kesihatan Masyarakat, 12 (1). ISSN 1675-1663 http://www.communityhealthjournal.org/detailarticle.asp?id=157&issue=Vol12(1):2006
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institution Universiti Kebangasaan Malaysia
building UKM Institutional Repository
collection Online Access
language English
description Neurobehavioral test has been used extensively and successfully in many countries to determine neurotoxic effects of various compounds. To determine neurotoxic effects of lead, a cross sectional studies was conducted on 141 male workers from two local battery manufacturing factories using' Neurobehavioral Core Test Batteries' ( NCTB) from' World Health Organisation'. These NCTB consist of several tests which can highlight various neuropsychological functions and a list of questionnaire for subjective symptoms. The workers, were divided into two groups based on their blood lead levels ( PbB ), the first group for those with PbB < 40 µg/dl with mean PbB 27.19 ± 10.23 and the second group with PbB > 40 µg/dl with mean PbB 53.10 ± 11.13. Student t-test has shown significant different between the two groups in neurobehavioral test performance such as Digit Symbol ( p= 0.02 ), Digit Backward ( p=0.01 ), Santa Ana preferred hand ( p=0.04 ), Santa Ana both hands ( p=0.02 ), Aiming Pursuit Test ( p=0.0002) and Trail B ( p= 0.0004 ). Workers from the second group also reported higher subjective symptoms of weakness in lower limbs and anorexia. Factors which have influenced on PbB were jobs category ( p=0.0001 ), work duration (p=0.04 ), chemical exposure ( p= 0.04 ), previous lead exposure ( p= 0.01 ) and usage of personal protective device ( p= 0.04 ). Significant correlation was found between PbB and neurobehavioral test performance such as Digit Symbol ( r= -0.04348 ), Digit Forward ( r= -0.2107 ), Digit Backward ( r= - 0.0003 ), Aiming Pursuit Test .( r= -0.2476 ) and Trail B ( r='0.3040 ). Regression analysis has shown reduction in cognitive and concentration functions with PbB level less that 30 µg/dl and maximum lead effect at Digit Symbol's score of 40. This study has shown that lead has led to impairment of cognitive, concentration, memory and motor steadiness functions and has proven the ability of neurobehavioral test in detecting lead toxicity at low levels.
format Article
author Mazrura Sahani,
Noor Hassim Ismail,
spellingShingle Mazrura Sahani,
Noor Hassim Ismail,
Neurobehavioral test performances in lead exposed in lead exposed workers, 1996
author_facet Mazrura Sahani,
Noor Hassim Ismail,
author_sort Mazrura Sahani,
title Neurobehavioral test performances in lead exposed in lead exposed workers, 1996
title_short Neurobehavioral test performances in lead exposed in lead exposed workers, 1996
title_full Neurobehavioral test performances in lead exposed in lead exposed workers, 1996
title_fullStr Neurobehavioral test performances in lead exposed in lead exposed workers, 1996
title_full_unstemmed Neurobehavioral test performances in lead exposed in lead exposed workers, 1996
title_sort neurobehavioral test performances in lead exposed in lead exposed workers, 1996
publisher Department Of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia
publishDate 2006
url http://journalarticle.ukm.my/4520/
http://journalarticle.ukm.my/4520/
http://journalarticle.ukm.my/4520/1/Vol12%281%29-Rizal.pdf
first_indexed 2023-09-18T19:41:44Z
last_indexed 2023-09-18T19:41:44Z
_version_ 1777405635920396288

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