Changes in hepatic phosphoprotein levels in mice infected with plasmodium berghei

Hepatic phosphoprotein levels are altered in mouse liver as a manifestation of bacteria, virus or parasite infection. Identification of signaling pathways mediated by these hepatic proteins contribute to the current understanding of the mechanism of pathogenesis in malarial infection. The present st...

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Main Authors:	Pramila Maniam, Zainal Abidin Abu Hassan, Noor Embi, Hasidah Mohd Sidek
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2012
Online Access:	http://journalarticle.ukm.my/4859/ http://journalarticle.ukm.my/4859/ http://journalarticle.ukm.my/4859/1/09%2520Pramila%2520Maniam.pdf

id	ukm-4859
recordtype	eprints
spelling	ukm-48592016-12-14T06:37:08Z http://journalarticle.ukm.my/4859/ Changes in hepatic phosphoprotein levels in mice infected with plasmodium berghei Pramila Maniam, Zainal Abidin Abu Hassan, Noor Embi, Hasidah Mohd Sidek, Hepatic phosphoprotein levels are altered in mouse liver as a manifestation of bacteria, virus or parasite infection. Identification of signaling pathways mediated by these hepatic proteins contribute to the current understanding of the mechanism of pathogenesis in malarial infection. The present study was undertaken to evaluate the changes in hepatic phosphoprotein levels during Plasmodium berghei infection. Our study revealed changes in levels of three hepatic phosphoproteins following P. berghei infection compared to non-infected controls. Peptide fragment sequence analysis using tandem mass spectrometry (MS/MS) showed these hepatic proteins to be homologs to haemoglobin beta (HBB), class Pi glutathione S-tranferase (GSTPi) and carbonic anhydrase III (CAIII) proteins of Mus musculus species respectively from the NCBInr sequence database. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis predicted the involvement of these proteins in specific pathways in Mus musculus species; GSTPi in glutathione and drug metabolism and CAIII in nitrogen metabolism. This shows that P. berghei infection affects similar signaling pathways as those reported in other pathogenic infections such as that related to GSTPi and CAIII in response to oxidative stress. Universiti Kebangsaan Malaysia 2012-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/4859/1/09%2520Pramila%2520Maniam.pdf Pramila Maniam, and Zainal Abidin Abu Hassan, and Noor Embi, and Hasidah Mohd Sidek, (2012) Changes in hepatic phosphoprotein levels in mice infected with plasmodium berghei. Sains Malaysiana, 41 (6). pp. 721-729. ISSN 0126-6039 http://www.ukm.my/jsm/contents.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Hepatic phosphoprotein levels are altered in mouse liver as a manifestation of bacteria, virus or parasite infection. Identification of signaling pathways mediated by these hepatic proteins contribute to the current understanding of the mechanism of pathogenesis in malarial infection. The present study was undertaken to evaluate the changes in hepatic phosphoprotein levels during Plasmodium berghei infection. Our study revealed changes in levels of three hepatic phosphoproteins following P. berghei infection compared to non-infected controls. Peptide fragment sequence analysis using tandem mass spectrometry (MS/MS) showed these hepatic proteins to be homologs to haemoglobin beta (HBB), class Pi glutathione S-tranferase (GSTPi) and carbonic anhydrase III (CAIII) proteins of Mus musculus species respectively from the NCBInr sequence database. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis predicted the involvement of these proteins in specific pathways in Mus musculus species; GSTPi in glutathione and drug metabolism and CAIII in nitrogen metabolism. This shows that P. berghei infection affects similar signaling pathways as those reported in other pathogenic infections such as that related to GSTPi and CAIII in response to oxidative stress.
format	Article
author	Pramila Maniam, Zainal Abidin Abu Hassan, Noor Embi, Hasidah Mohd Sidek,
spellingShingle	Pramila Maniam, Zainal Abidin Abu Hassan, Noor Embi, Hasidah Mohd Sidek, Changes in hepatic phosphoprotein levels in mice infected with plasmodium berghei
author_facet	Pramila Maniam, Zainal Abidin Abu Hassan, Noor Embi, Hasidah Mohd Sidek,
author_sort	Pramila Maniam,
title	Changes in hepatic phosphoprotein levels in mice infected with plasmodium berghei
title_short	Changes in hepatic phosphoprotein levels in mice infected with plasmodium berghei
title_full	Changes in hepatic phosphoprotein levels in mice infected with plasmodium berghei
title_fullStr	Changes in hepatic phosphoprotein levels in mice infected with plasmodium berghei
title_full_unstemmed	Changes in hepatic phosphoprotein levels in mice infected with plasmodium berghei
title_sort	changes in hepatic phosphoprotein levels in mice infected with plasmodium berghei
publisher	Universiti Kebangsaan Malaysia
publishDate	2012
url	http://journalarticle.ukm.my/4859/ http://journalarticle.ukm.my/4859/ http://journalarticle.ukm.my/4859/1/09%2520Pramila%2520Maniam.pdf
first_indexed	2023-09-18T19:42:43Z
last_indexed	2023-09-18T19:42:43Z
_version_	1777405697662648320

Changes in hepatic phosphoprotein levels in mice infected with plasmodium berghei

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