Apparent factor IX inhibitor.

Apparent factor IX inhibitor.

The causes of an isolated prolonged activated partial thromboplastin time (APTT) with a normal prothrombin time (PT) are either a deficiency of clotting factors VIII, IX, XI or XII or the presence of an inhibitor. The inhibitor may be specific to an individual clotting factor or it may be a non-spec...

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Main Authors: Jameela, S, Rozika, P, Rizalman, J, Phan, CL, Visalachy, P, Chang, KM
Format: Article
Language:English
Published: Penerbit UKM 2011
Online Access:http://journalarticle.ukm.my/5325/
http://journalarticle.ukm.my/5325/
http://journalarticle.ukm.my/5325/1/10-MS_123_%28126-130%29.pdf
id ukm-5325
recordtype eprints
spelling ukm-53252016-12-14T06:38:06Z http://journalarticle.ukm.my/5325/ Apparent factor IX inhibitor. Jameela, S Rozika, P Rizalman, J Phan, CL Visalachy, P Chang, KM The causes of an isolated prolonged activated partial thromboplastin time (APTT) with a normal prothrombin time (PT) are either a deficiency of clotting factors VIII, IX, XI or XII or the presence of an inhibitor. The inhibitor may be specific to an individual clotting factor or it may be a non-specific inhibitor like the lupus anticoagulant which has opposite therapeutic implications. We report a patient referred to our hospital for treatment that was previously diagnosed at another medical institution as an acquired factor IX inhibitor following an investigation for a prolonged APTT. On further testing this turned out to be a potent lupus anticoagulant which interfered with the phospholipid-dependent factor assays. The use of dilution studies, chromogenic assays and phospholipid neutralization can help differentiate these inhibitors. Great care must be taken in the interpretation of factor assays in the presence of lupus anti-coagulant to avoid misdiagnosis and inappropriate treatment. Penerbit UKM 2011-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5325/1/10-MS_123_%28126-130%29.pdf Jameela, S and Rozika, P and Rizalman, J and Phan, CL and Visalachy, P and Chang, KM (2011) Apparent factor IX inhibitor. Medicine & Health, 6 (2). pp. 126-130. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal
repository_type Digital Repository
institution_category Local University
institution Universiti Kebangasaan Malaysia
building UKM Institutional Repository
collection Online Access
language English
description The causes of an isolated prolonged activated partial thromboplastin time (APTT) with a normal prothrombin time (PT) are either a deficiency of clotting factors VIII, IX, XI or XII or the presence of an inhibitor. The inhibitor may be specific to an individual clotting factor or it may be a non-specific inhibitor like the lupus anticoagulant which has opposite therapeutic implications. We report a patient referred to our hospital for treatment that was previously diagnosed at another medical institution as an acquired factor IX inhibitor following an investigation for a prolonged APTT. On further testing this turned out to be a potent lupus anticoagulant which interfered with the phospholipid-dependent factor assays. The use of dilution studies, chromogenic assays and phospholipid neutralization can help differentiate these inhibitors. Great care must be taken in the interpretation of factor assays in the presence of lupus anti-coagulant to avoid misdiagnosis and inappropriate treatment.
format Article
author Jameela, S
Rozika, P
Rizalman, J
Phan, CL
Visalachy, P
Chang, KM
spellingShingle Jameela, S
Rozika, P
Rizalman, J
Phan, CL
Visalachy, P
Chang, KM
Apparent factor IX inhibitor.
author_facet Jameela, S
Rozika, P
Rizalman, J
Phan, CL
Visalachy, P
Chang, KM
author_sort Jameela, S
title Apparent factor IX inhibitor.
title_short Apparent factor IX inhibitor.
title_full Apparent factor IX inhibitor.
title_fullStr Apparent factor IX inhibitor.
title_full_unstemmed Apparent factor IX inhibitor.
title_sort apparent factor ix inhibitor.
publisher Penerbit UKM
publishDate 2011
url http://journalarticle.ukm.my/5325/
http://journalarticle.ukm.my/5325/
http://journalarticle.ukm.my/5325/1/10-MS_123_%28126-130%29.pdf
first_indexed 2023-09-18T19:43:48Z
last_indexed 2023-09-18T19:43:48Z
_version_ 1777405765637636096

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