Early lineage switch from T-acute lymphoblastic leukaemia to common B-all.
Leukaemic stem cells have heterogenous differentiation potential. The immunophenotypes of blast cells are usually consistent throughout the disease course even at relapse. Rarely, blast cells may undergo a ‘lineage switch’ during the course of disease especially during relapse. We would like to high...
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Penerbit UKM
2011
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| Online Access: | http://journalarticle.ukm.my/5326/ http://journalarticle.ukm.my/5326/ http://journalarticle.ukm.my/5326/1/11-MS126_%28131-138%29.pdf |
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ukm-53262016-12-14T06:38:07Z http://journalarticle.ukm.my/5326/ Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. Hafiza, A Azura, AH Azma, RZ Azlin, I Zarina, AL Hamidah, NH Leukaemic stem cells have heterogenous differentiation potential. The immunophenotypes of blast cells are usually consistent throughout the disease course even at relapse. Rarely, blast cells may undergo a ‘lineage switch’ during the course of disease especially during relapse. We would like to highlight such a case in a 10-year old boy who presented with a two weeks history of lethargy, poor appetite, low grade fever, respiratory distress, cardiac failure, generalized oedema and hepatosplenomegaly. Full blood count showed a leucocyte count of 41.5x109/L and platelet count of 37x109/L. The peripheral blood film showed presence of numerous blast cells. Bone marrow aspiration revealed a hypercellular marrow, which consisted of mainly blast cells with high nuclear to cytoplasmic ratio and inconspicuous nucleoli. Immunophenotyping and cytochemistry results were consistent with the diagnosis of T-cell acute lymphoblastic leukaemia. The patient achieved remission after treatment with UK ALL 97 protocol, regime B chemotherapy. However, he relapsed seven months after the initial diagnosis with 26% blast cells in the bone marrow aspirate. The majority was L1 blast cells admixed with some L2 blast cells. Immunophenotyping was consistent with common precursor B acute lymphoblastic leukaemia. The treatment was changed to a more lineage specific chemotherapy. Nonetheless, the patient never achieved remission and was planned for palliative management. This case illustrated a unique and rare case of rapid lineage switch from T-cell acute lymphoblastic leukaemia to common precursor B-cell acute lymphoblastic leukaemia. Penerbit UKM 2011-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5326/1/11-MS126_%28131-138%29.pdf Hafiza, A and Azura, AH and Azma, RZ and Azlin, I and Zarina, AL and Hamidah, NH (2011) Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. Medicine & Health, 6 (2). pp. 131-138. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
Universiti Kebangasaan Malaysia |
| building |
UKM Institutional Repository |
| collection |
Online Access |
| language |
English |
| description |
Leukaemic stem cells have heterogenous differentiation potential. The immunophenotypes of blast cells are usually consistent throughout the disease course even at relapse. Rarely, blast cells may undergo a ‘lineage switch’ during the course of disease especially during relapse. We would like to highlight such a case in a 10-year old boy who presented with a two weeks history of lethargy, poor appetite, low grade fever, respiratory distress, cardiac failure, generalized oedema and hepatosplenomegaly. Full blood count showed a leucocyte count of 41.5x109/L and platelet count of 37x109/L. The peripheral blood film showed presence of numerous blast cells. Bone marrow aspiration revealed a hypercellular marrow, which consisted of mainly blast cells with high nuclear to cytoplasmic ratio and inconspicuous nucleoli. Immunophenotyping and cytochemistry results were consistent with the diagnosis of T-cell acute lymphoblastic leukaemia. The patient achieved remission after treatment with UK ALL 97 protocol, regime B chemotherapy. However, he relapsed seven months after the initial diagnosis with 26% blast cells in the bone marrow aspirate. The majority was L1 blast cells admixed with some L2 blast cells. Immunophenotyping was consistent with common precursor B acute lymphoblastic leukaemia. The treatment was changed to a more lineage specific chemotherapy. Nonetheless, the patient never achieved remission and was planned for palliative management. This case illustrated a unique and rare case of rapid lineage switch from T-cell acute lymphoblastic leukaemia to common precursor B-cell acute lymphoblastic leukaemia. |
| format |
Article |
| author |
Hafiza, A Azura, AH Azma, RZ Azlin, I Zarina, AL Hamidah, NH |
| spellingShingle |
Hafiza, A Azura, AH Azma, RZ Azlin, I Zarina, AL Hamidah, NH Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. |
| author_facet |
Hafiza, A Azura, AH Azma, RZ Azlin, I Zarina, AL Hamidah, NH |
| author_sort |
Hafiza, A |
| title |
Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. |
| title_short |
Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. |
| title_full |
Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. |
| title_fullStr |
Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. |
| title_full_unstemmed |
Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. |
| title_sort |
early lineage switch from t-acute lymphoblastic leukaemia to common b-all. |
| publisher |
Penerbit UKM |
| publishDate |
2011 |
| url |
http://journalarticle.ukm.my/5326/ http://journalarticle.ukm.my/5326/ http://journalarticle.ukm.my/5326/1/11-MS126_%28131-138%29.pdf |
| first_indexed |
2023-09-18T19:43:48Z |
| last_indexed |
2023-09-18T19:43:48Z |
| _version_ |
1777405765781291008 |