Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi)

Three new compounds of dibutyltin(IV) with N alkylcyclohexyldithiocarbamate were successfully synthesized using in situ methods. Elemental analysis data of these complexes were in agreement with the general formula of (C4H9)2Sn[S2CNR(C6H11)]2 (R = CH3, C2H5, i-C3H7). Infrared spectra showed that the...

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Main Authors:	Normah Awang, Ibrahim Baba
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2012
Online Access:	http://journalarticle.ukm.my/5435/ http://journalarticle.ukm.my/5435/ http://journalarticle.ukm.my/5435/1/06_Normah_Awang.pdf

id	ukm-5435
recordtype	eprints
spelling	ukm-54352016-12-14T06:38:26Z http://journalarticle.ukm.my/5435/ Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi) Normah Awang, Ibrahim Baba, Three new compounds of dibutyltin(IV) with N alkylcyclohexyldithiocarbamate were successfully synthesized using in situ methods. Elemental analysis data of these complexes were in agreement with the general formula of (C4H9)2Sn[S2CNR(C6H11)]2 (R = CH3, C2H5, i-C3H7). Infrared spectra showed that the thioureide bands, ν(C=N) appeared in the region of 1475 - 1479 cm-1, ν(C=S) bands in the region of 978 - 998 cm-1 and ν(Sn-S) bands in the region of 375 – 389 cm-1. Crystal structure of dibutyltin(IV) ethylcyclohexyldithiocarbamate showed a triclinic system and space group P-1. The crystal structure of the dithiocarbamate ligands were bidentically chelated to the tin atom with Sn-S unsymmetrical: Sn(1)-S(1) = 2.9255(11) and Sn(1)-S(2) = 2.5419(10); Sn(1)-S(3) = 2.8922(9) and Sn(1)-S(4) = 2.5293(10)Å. These compounds were screened for antibacterial activity against four bacteria species using the disc diffusion method. The results showed that (C4H9)2Sn[S2CN(i-C3H7)(C6H11)]2 was mildly active against those three bacteria. Whereas all of these compounds exhibited in vitro cytotoxicity activity toward human leukemic promyelocites HL-60 cell line with CD50 values lower than 1.00 μg/mL. Universiti Kebangsaan Malaysia 2012-08 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5435/1/06_Normah_Awang.pdf Normah Awang, and Ibrahim Baba, (2012) Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi). Sains Malaysiana, 41 (8). pp. 977-982. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Three new compounds of dibutyltin(IV) with N alkylcyclohexyldithiocarbamate were successfully synthesized using in situ methods. Elemental analysis data of these complexes were in agreement with the general formula of (C4H9)2Sn[S2CNR(C6H11)]2 (R = CH3, C2H5, i-C3H7). Infrared spectra showed that the thioureide bands, ν(C=N) appeared in the region of 1475 - 1479 cm-1, ν(C=S) bands in the region of 978 - 998 cm-1 and ν(Sn-S) bands in the region of 375 – 389 cm-1. Crystal structure of dibutyltin(IV) ethylcyclohexyldithiocarbamate showed a triclinic system and space group P-1. The crystal structure of the dithiocarbamate ligands were bidentically chelated to the tin atom with Sn-S unsymmetrical: Sn(1)-S(1) = 2.9255(11) and Sn(1)-S(2) = 2.5419(10); Sn(1)-S(3) = 2.8922(9) and Sn(1)-S(4) = 2.5293(10)Å. These compounds were screened for antibacterial activity against four bacteria species using the disc diffusion method. The results showed that (C4H9)2Sn[S2CN(i-C3H7)(C6H11)]2 was mildly active against those three bacteria. Whereas all of these compounds exhibited in vitro cytotoxicity activity toward human leukemic promyelocites HL-60 cell line with CD50 values lower than 1.00 μg/mL.
format	Article
author	Normah Awang, Ibrahim Baba,
spellingShingle	Normah Awang, Ibrahim Baba, Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi)
author_facet	Normah Awang, Ibrahim Baba,
author_sort	Normah Awang,
title	Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi)
title_short	Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi)
title_full	Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi)
title_fullStr	Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi)
title_full_unstemmed	Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi)
title_sort	diorganotin(iv) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (sebatian diorganostanum(iv) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi)
publisher	Universiti Kebangsaan Malaysia
publishDate	2012
url	http://journalarticle.ukm.my/5435/ http://journalarticle.ukm.my/5435/ http://journalarticle.ukm.my/5435/1/06_Normah_Awang.pdf
first_indexed	2023-09-18T19:44:08Z
last_indexed	2023-09-18T19:44:08Z
_version_	1777405786919534592

Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds: synthesis, characterization and biological activities (Sebatian diorganostanum(IV) alkilsikloheksilditiokarbamat: sintesis,pencirian dan aktiviti biologi)

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