Toxic effects of sapium baccatum (Ludai) extract in rats

Sapium baccatum is usually used as a timber in Malaysia. Its medicinal values are not well known and very little research has been conducted concerning the plant. Consequently, this study was conducted to observe toxicity effects of hexane extract of stem bark of S. baccatum. The toxicity effects we...

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Main Authors:	Muhammad Taher, Nur Azura Mat Alewi, Deny Susanti, Zaitunnatakhin Zamli, Norazsida Ramli, Nurulwahida Saad
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2012
Online Access:	http://journalarticle.ukm.my/5578/ http://journalarticle.ukm.my/5578/ http://journalarticle.ukm.my/5578/1/11%2520Muhammad%2520Taher.pdf

id	ukm-5578
recordtype	eprints
spelling	ukm-55782016-12-14T06:38:52Z http://journalarticle.ukm.my/5578/ Toxic effects of sapium baccatum (Ludai) extract in rats Muhammad Taher, Nur Azura Mat Alewi, Deny Susanti, Zaitunnatakhin Zamli, Norazsida Ramli, Nurulwahida Saad, Sapium baccatum is usually used as a timber in Malaysia. Its medicinal values are not well known and very little research has been conducted concerning the plant. Consequently, this study was conducted to observe toxicity effects of hexane extract of stem bark of S. baccatum. The toxicity effects were assessed through observation of physiological changes of the rats as well as through gross and histological examinations of its livers. The doses for the treated groups were given intraperitoneally for T2, T3 and T4 group which were given 100, 250 and 500 mg/kg, respectively. Meanwhile, control group (T1) was administered with 80% PEG 200 only. The observation period was 14 days. If the rat died, it was dissected and the liver was removed and examined. Some physiological effects observed include ataxia and hind-legs paralysis. The gross observations of the livers, growth of abnormal spots and connective tissues attachment to lobes of the livers were observed. The experiment was followed by histopathological observation, which indicated the presence of abnormal hepatocytes with a distorted shape and undefined cell linings for T2 group. Results also indicated an increase in the distortion of hepatocytes, presence of massive cytoplasm and necrosis of hepatocytes for T3 and T4 groups. Results suggest that non polar extract of the stem bark of S. baccatum may promote toxic effects to the animals. Universiti Kebangsaan Malaysia 2012-11 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5578/1/11%2520Muhammad%2520Taher.pdf Muhammad Taher, and Nur Azura Mat Alewi, and Deny Susanti, and Zaitunnatakhin Zamli, and Norazsida Ramli, and Nurulwahida Saad, (2012) Toxic effects of sapium baccatum (Ludai) extract in rats. Sains Malaysiana, 41 (11). pp. 1423-1429. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Sapium baccatum is usually used as a timber in Malaysia. Its medicinal values are not well known and very little research has been conducted concerning the plant. Consequently, this study was conducted to observe toxicity effects of hexane extract of stem bark of S. baccatum. The toxicity effects were assessed through observation of physiological changes of the rats as well as through gross and histological examinations of its livers. The doses for the treated groups were given intraperitoneally for T2, T3 and T4 group which were given 100, 250 and 500 mg/kg, respectively. Meanwhile, control group (T1) was administered with 80% PEG 200 only. The observation period was 14 days. If the rat died, it was dissected and the liver was removed and examined. Some physiological effects observed include ataxia and hind-legs paralysis. The gross observations of the livers, growth of abnormal spots and connective tissues attachment to lobes of the livers were observed. The experiment was followed by histopathological observation, which indicated the presence of abnormal hepatocytes with a distorted shape and undefined cell linings for T2 group. Results also indicated an increase in the distortion of hepatocytes, presence of massive cytoplasm and necrosis of hepatocytes for T3 and T4 groups. Results suggest that non polar extract of the stem bark of S. baccatum may promote toxic effects to the animals.
format	Article
author	Muhammad Taher, Nur Azura Mat Alewi, Deny Susanti, Zaitunnatakhin Zamli, Norazsida Ramli, Nurulwahida Saad,
spellingShingle	Muhammad Taher, Nur Azura Mat Alewi, Deny Susanti, Zaitunnatakhin Zamli, Norazsida Ramli, Nurulwahida Saad, Toxic effects of sapium baccatum (Ludai) extract in rats
author_facet	Muhammad Taher, Nur Azura Mat Alewi, Deny Susanti, Zaitunnatakhin Zamli, Norazsida Ramli, Nurulwahida Saad,
author_sort	Muhammad Taher,
title	Toxic effects of sapium baccatum (Ludai) extract in rats
title_short	Toxic effects of sapium baccatum (Ludai) extract in rats
title_full	Toxic effects of sapium baccatum (Ludai) extract in rats
title_fullStr	Toxic effects of sapium baccatum (Ludai) extract in rats
title_full_unstemmed	Toxic effects of sapium baccatum (Ludai) extract in rats
title_sort	toxic effects of sapium baccatum (ludai) extract in rats
publisher	Universiti Kebangsaan Malaysia
publishDate	2012
url	http://journalarticle.ukm.my/5578/ http://journalarticle.ukm.my/5578/ http://journalarticle.ukm.my/5578/1/11%2520Muhammad%2520Taher.pdf
first_indexed	2023-09-18T19:44:33Z
last_indexed	2023-09-18T19:44:33Z
_version_	1777405812478574592

Toxic effects of sapium baccatum (Ludai) extract in rats

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