Qualitative and quantitative assessment of immune cells in oral mucosal lichen planus (OMLP)

Cell mediated immunity is currently thought to be involved in the pathogenesis of oral mucosal lichen planus (OMLP). However, literature reveals there is no large scale data of immunohistochemistry (IHC) study on these immune cell populations. The aim of this study was to assess and compare immune c...

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Main Authors:	Sinon, S.H, Rich, A.M, Firth, N.A, Seymour, G.J
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2013
Online Access:	http://journalarticle.ukm.my/5706/ http://journalarticle.ukm.my/5706/ http://journalarticle.ukm.my/5706/1/11%2520Suraya.pdf

id	ukm-5706
recordtype	eprints
spelling	ukm-57062016-12-14T06:39:15Z http://journalarticle.ukm.my/5706/ Qualitative and quantitative assessment of immune cells in oral mucosal lichen planus (OMLP) Sinon, S.H Rich, A.M Firth, N.A Seymour, G.J Cell mediated immunity is currently thought to be involved in the pathogenesis of oral mucosal lichen planus (OMLP). However, literature reveals there is no large scale data of immunohistochemistry (IHC) study on these immune cell populations. The aim of this study was to assess and compare immune cell surface identification markers CD3, CD4, CD8, CD19 and CD83 between the OMLP (n=40) and non-specific inflammatory lesions (as control group) (n=10) qualitatively and quantitatively. Kruskal-Wallis and Mann Whitney U tests have been used to make comparison between the test and control group, p values of less than 0.05 was considered to be statistically significant. T cell surface markers (CD3+, CD4+ and CD8+), B cells (CD19+) and mature dendritic cells (CD83+) showed intense immunostaining in OMLP tissues with a significantly higher expression of positive cells than in the control group (p<0.05). CD3, CD4 and CD8+ve T cells were the predominant inflammatory cell type in OMLP rather than CD19+ B cells, supporting the role of Th1 cells in the pathogenesis of OMLP. CD83+ mature dendritic cells were present in the least number and were mostly localized to areas where there were aggregates of lymphocyte. There was a positive correlation and direct relationship between T and B lymphocyte subsets whereby as one subset increased, the other follows. Universiti Kebangsaan Malaysia 2013-01 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5706/1/11%2520Suraya.pdf Sinon, S.H and Rich, A.M and Firth, N.A and Seymour, G.J (2013) Qualitative and quantitative assessment of immune cells in oral mucosal lichen planus (OMLP). Sains Malaysiana, 42 (1). pp. 65-71. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Cell mediated immunity is currently thought to be involved in the pathogenesis of oral mucosal lichen planus (OMLP). However, literature reveals there is no large scale data of immunohistochemistry (IHC) study on these immune cell populations. The aim of this study was to assess and compare immune cell surface identification markers CD3, CD4, CD8, CD19 and CD83 between the OMLP (n=40) and non-specific inflammatory lesions (as control group) (n=10) qualitatively and quantitatively. Kruskal-Wallis and Mann Whitney U tests have been used to make comparison between the test and control group, p values of less than 0.05 was considered to be statistically significant. T cell surface markers (CD3+, CD4+ and CD8+), B cells (CD19+) and mature dendritic cells (CD83+) showed intense immunostaining in OMLP tissues with a significantly higher expression of positive cells than in the control group (p<0.05). CD3, CD4 and CD8+ve T cells were the predominant inflammatory cell type in OMLP rather than CD19+ B cells, supporting the role of Th1 cells in the pathogenesis of OMLP. CD83+ mature dendritic cells were present in the least number and were mostly localized to areas where there were aggregates of lymphocyte. There was a positive correlation and direct relationship between T and B lymphocyte subsets whereby as one subset increased, the other follows.
format	Article
author	Sinon, S.H Rich, A.M Firth, N.A Seymour, G.J
spellingShingle	Sinon, S.H Rich, A.M Firth, N.A Seymour, G.J Qualitative and quantitative assessment of immune cells in oral mucosal lichen planus (OMLP)
author_facet	Sinon, S.H Rich, A.M Firth, N.A Seymour, G.J
author_sort	Sinon, S.H
title	Qualitative and quantitative assessment of immune cells in oral mucosal lichen planus (OMLP)
title_short	Qualitative and quantitative assessment of immune cells in oral mucosal lichen planus (OMLP)
title_full	Qualitative and quantitative assessment of immune cells in oral mucosal lichen planus (OMLP)
title_fullStr	Qualitative and quantitative assessment of immune cells in oral mucosal lichen planus (OMLP)
title_full_unstemmed	Qualitative and quantitative assessment of immune cells in oral mucosal lichen planus (OMLP)
title_sort	qualitative and quantitative assessment of immune cells in oral mucosal lichen planus (omlp)
publisher	Universiti Kebangsaan Malaysia
publishDate	2013
url	http://journalarticle.ukm.my/5706/ http://journalarticle.ukm.my/5706/ http://journalarticle.ukm.my/5706/1/11%2520Suraya.pdf
first_indexed	2023-09-18T19:44:53Z
last_indexed	2023-09-18T19:44:53Z
_version_	1777405833878962176

Qualitative and quantitative assessment of immune cells in oral mucosal lichen planus (OMLP)

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