Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing

This study explored TPMT genotype-phenotype correlation in a group of acute lymphoblastic leukemia (ALL) patients to investigate the potential of TPMT genotyping for personalized thiopurine dosing. Genotyping for G238C (TPMT*2), G460A (TPMT*3B) and A719G (TPMT*3C) loci was determined in 89 subjects...

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Main Authors:	Hui-min, Neoh, Mee, Lee Looi, Muhiddin Ishak, Mohd Ridhwan Abd Razak, Noor Hamidah Hussin, Zarina Latiff, Hamidah Alias, Rahman Jamal
Format:	Article
Language:	English
Published:	Penerbit UKM 2012
Online Access:	http://journalarticle.ukm.my/6092/ http://journalarticle.ukm.my/6092/ http://journalarticle.ukm.my/6092/1/2011-1-17.pdf

id	ukm-6092
recordtype	eprints
spelling	ukm-60922016-12-14T06:40:21Z http://journalarticle.ukm.my/6092/ Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing Hui-min, Neoh Mee, Lee Looi Muhiddin Ishak, Mohd Ridhwan Abd Razak, Noor Hamidah Hussin, Zarina Latiff, Hamidah Alias, Rahman Jamal, This study explored TPMT genotype-phenotype correlation in a group of acute lymphoblastic leukemia (ALL) patients to investigate the potential of TPMT genotyping for personalized thiopurine dosing. Genotyping for G238C (TPMT2), G460A (TPMT3B) and A719G (TPMT3C) loci was determined in 89 subjects via PCR, while TPMT activity was measured using HPLC. TPMT3C was the only mutant allele detected in 4 heterozygous carriers. These patients had significantly lower (23.0 nmol/g Hb/h) TPMT activity compared to wildtype patients (51.0 nmol/g Hb/h) (p = 0.003). Positive correlation between TPMT genotype and phenotype projects the possibility of using TPMT genotyping as a guide prior thiopurine drug administration. . Penerbit UKM 2012-01-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/6092/1/2011-1-17.pdf Hui-min, Neoh and Mee, Lee Looi and Muhiddin Ishak, and Mohd Ridhwan Abd Razak, and Noor Hamidah Hussin, and Zarina Latiff, and Hamidah Alias, and Rahman Jamal, (2012) Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing. Asia-Pacific Journal of Molecular Medicine, 2 ((1):1). pp. 1-3. ISSN 2232-0326 http://www.ukm.my/apjmm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	This study explored TPMT genotype-phenotype correlation in a group of acute lymphoblastic leukemia (ALL) patients to investigate the potential of TPMT genotyping for personalized thiopurine dosing. Genotyping for G238C (TPMT2), G460A (TPMT3B) and A719G (TPMT3C) loci was determined in 89 subjects via PCR, while TPMT activity was measured using HPLC. TPMT3C was the only mutant allele detected in 4 heterozygous carriers. These patients had significantly lower (23.0 nmol/g Hb/h) TPMT activity compared to wildtype patients (51.0 nmol/g Hb/h) (p = 0.003). Positive correlation between TPMT genotype and phenotype projects the possibility of using TPMT genotyping as a guide prior thiopurine drug administration. .
format	Article
author	Hui-min, Neoh Mee, Lee Looi Muhiddin Ishak, Mohd Ridhwan Abd Razak, Noor Hamidah Hussin, Zarina Latiff, Hamidah Alias, Rahman Jamal,
spellingShingle	Hui-min, Neoh Mee, Lee Looi Muhiddin Ishak, Mohd Ridhwan Abd Razak, Noor Hamidah Hussin, Zarina Latiff, Hamidah Alias, Rahman Jamal, Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing
author_facet	Hui-min, Neoh Mee, Lee Looi Muhiddin Ishak, Mohd Ridhwan Abd Razak, Noor Hamidah Hussin, Zarina Latiff, Hamidah Alias, Rahman Jamal,
author_sort	Hui-min, Neoh
title	Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing
title_short	Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing
title_full	Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing
title_fullStr	Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing
title_full_unstemmed	Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing
title_sort	positive tpmt genotype-phenotype correlation underscores importance of tpmt genotyping for personalized thiopurine dosing
publisher	Penerbit UKM
publishDate	2012
url	http://journalarticle.ukm.my/6092/ http://journalarticle.ukm.my/6092/ http://journalarticle.ukm.my/6092/1/2011-1-17.pdf
first_indexed	2023-09-18T19:45:57Z
last_indexed	2023-09-18T19:45:57Z
_version_	1777405900945883136

Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing

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