Genotoxic effect of zinc and cadmium following single and binary mixture exposures in tilapia (Oreochromis niloticus) using micronucleus test
The aim of this study was to investigate the genotoxicity effect of Cd and Zn and their binary mixtures in tilapia fish Oreochromis niloticus using the micronucleus test. Two cytogenetic end points were considered; the frequencies of micronucleated cells and nuclear abnormalities. Fishes were expose...
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Universiti Kebangsaan Malaysia
2014
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| Online Access: | http://journalarticle.ukm.my/7261/ http://journalarticle.ukm.my/7261/ http://journalarticle.ukm.my/7261/1/12_S.N.N_Abu_Bakar.pdf |
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ukm-72612016-12-14T06:43:33Z http://journalarticle.ukm.my/7261/ Genotoxic effect of zinc and cadmium following single and binary mixture exposures in tilapia (Oreochromis niloticus) using micronucleus test Abu Bakar, S.N.N. Ashriya, A. Shuib, A.S. Razak, S.A. The aim of this study was to investigate the genotoxicity effect of Cd and Zn and their binary mixtures in tilapia fish Oreochromis niloticus using the micronucleus test. Two cytogenetic end points were considered; the frequencies of micronucleated cells and nuclear abnormalities. Fishes were exposed to 4.63 mg/L Cd, 7.50 mg/L Zn and 4.63 mg/L Cd + 7.50 mg/L Zn mixture for the period of 24, 48, 72 and 96 h. The results showed that the frequencies of micronuclei and nuclear abnormalities in the erythrocyte were significantly increased in all groups of treatments when compared with the control group (0 exposures). In addition, the highest frequencies of micronucleated and nuclear abnormalities were obtained after 48 h exposure in almost all cases (except in the mixture of Cd+Zn) and decreased after 72 and 96 h exposure. Frequencies of micronuclei and erythrocytes with nuclear abnormalities exposed to a mixture of Cd+Zn in O. niloticus were always lower at all-time points (after 24, 48, 72 and 96 h) than that of a single Cd and Zn exposure. Therefore, the study demonstrated that the genotoxic potential of these metal compounds and the simultaneous treatment of Cd and Zn suggest the presence of antagonistic interactions. Universiti Kebangsaan Malaysia 2014-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/7261/1/12_S.N.N_Abu_Bakar.pdf Abu Bakar, S.N.N. and Ashriya, A. and Shuib, A.S. and Razak, S.A. (2014) Genotoxic effect of zinc and cadmium following single and binary mixture exposures in tilapia (Oreochromis niloticus) using micronucleus test. Sains Malaysiana, 43 (7). pp. 1053-1059. ISSN 0126-6039 http://www.ukm.my/jsm/ |
| repository_type |
Digital Repository |
| institution_category |
Local University |
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Universiti Kebangasaan Malaysia |
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UKM Institutional Repository |
| collection |
Online Access |
| language |
English |
| description |
The aim of this study was to investigate the genotoxicity effect of Cd and Zn and their binary mixtures in tilapia fish Oreochromis niloticus using the micronucleus test. Two cytogenetic end points were considered; the frequencies of micronucleated cells and nuclear abnormalities. Fishes were exposed to 4.63 mg/L Cd, 7.50 mg/L Zn and 4.63 mg/L Cd + 7.50 mg/L Zn mixture for the period of 24, 48, 72 and 96 h. The results showed that the frequencies of micronuclei and nuclear abnormalities in the erythrocyte were significantly increased in all groups of treatments when compared with the control group (0 exposures). In addition, the highest frequencies of micronucleated and nuclear abnormalities were obtained after 48 h exposure in almost all cases (except in the mixture of Cd+Zn) and decreased after 72 and 96 h exposure. Frequencies of micronuclei and erythrocytes with nuclear abnormalities exposed to a mixture of Cd+Zn in O. niloticus were always lower at all-time points (after 24, 48, 72 and 96 h) than that of a single Cd and Zn exposure. Therefore, the study demonstrated that the genotoxic potential of these metal compounds and the simultaneous treatment of Cd and Zn suggest the presence of antagonistic interactions. |
| format |
Article |
| author |
Abu Bakar, S.N.N. Ashriya, A. Shuib, A.S. Razak, S.A. |
| spellingShingle |
Abu Bakar, S.N.N. Ashriya, A. Shuib, A.S. Razak, S.A. Genotoxic effect of zinc and cadmium following single and binary mixture exposures in tilapia (Oreochromis niloticus) using micronucleus test |
| author_facet |
Abu Bakar, S.N.N. Ashriya, A. Shuib, A.S. Razak, S.A. |
| author_sort |
Abu Bakar, S.N.N. |
| title |
Genotoxic effect of zinc and cadmium following single and binary mixture exposures in tilapia (Oreochromis niloticus) using micronucleus test |
| title_short |
Genotoxic effect of zinc and cadmium following single and binary mixture exposures in tilapia (Oreochromis niloticus) using micronucleus test |
| title_full |
Genotoxic effect of zinc and cadmium following single and binary mixture exposures in tilapia (Oreochromis niloticus) using micronucleus test |
| title_fullStr |
Genotoxic effect of zinc and cadmium following single and binary mixture exposures in tilapia (Oreochromis niloticus) using micronucleus test |
| title_full_unstemmed |
Genotoxic effect of zinc and cadmium following single and binary mixture exposures in tilapia (Oreochromis niloticus) using micronucleus test |
| title_sort |
genotoxic effect of zinc and cadmium following single and binary mixture exposures in tilapia (oreochromis niloticus) using micronucleus test |
| publisher |
Universiti Kebangsaan Malaysia |
| publishDate |
2014 |
| url |
http://journalarticle.ukm.my/7261/ http://journalarticle.ukm.my/7261/ http://journalarticle.ukm.my/7261/1/12_S.N.N_Abu_Bakar.pdf |
| first_indexed |
2023-09-18T19:49:11Z |
| last_indexed |
2023-09-18T19:49:11Z |
| _version_ |
1777406104328732672 |