Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets

The use of sustained release tablet formulation for non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin has shown its capability to protect the stomach lining from the adverse effect of gastric juice from the body. This study was carried out to evaluate the efficiency of sustained release ma...

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Main Authors:	Ibrahim Ijang, Mohd Cairul Iqbal Mohd Amin, Bukhori Abu Bakar
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2010
Online Access:	http://journalarticle.ukm.my/7398/ http://journalarticle.ukm.my/7398/ http://journalarticle.ukm.my/7398/1/01_Md_Yeaminhossain.pdf

id	ukm-7398
recordtype	eprints
spelling	ukm-73982016-12-14T06:43:57Z http://journalarticle.ukm.my/7398/ Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets Ibrahim Ijang, Mohd Cairul Iqbal Mohd Amin, Bukhori Abu Bakar, The use of sustained release tablet formulation for non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin has shown its capability to protect the stomach lining from the adverse effect of gastric juice from the body. This study was carried out to evaluate the efficiency of sustained release matrix tablet formulation using ketoprofen as a model drug with different polymers concentration. The tablets were prepared by the wet granulation method using hydrophilic polymer (hydroxypropyl methylcellulose), hydrophobic pH dependent polymer (Eudragit L100-55) and independent polymer (Eudragit RD 100) as matrix forming retarding materials at 10%w/w, 20%w/w and 30%w/w. All formulations were compressed using 10 mm concave faced punches. The compressed tablets were evaluated for uniformity of weight, friability, hardness, thickness, % drug content and in vitro dissolution test with regard to BP 2007. The results showed that the drug release rate was found to be governed by the type and concentration of polymer in the matrix system. Generally, increasing the polymeric concentration in the matrix tablets will decrease the rate of drug release. When the polymers were compared at similar concentration using t50%, the difference in drug release was found to be statistically significant (p<0.05). Based on the in vitro drug dissolution studies, the hydrophobic pH dependent polymer (Eudragit L100-55) showed a better zero drug release profile compared to other polymers. Universiti Kebangsaan Malaysia 2010-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/7398/1/01_Md_Yeaminhossain.pdf Ibrahim Ijang, and Mohd Cairul Iqbal Mohd Amin, and Bukhori Abu Bakar, (2010) Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets. Sains Malaysiana, 39 (5). pp. 737-745. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol39num5_2010/contentsVol39num5_2010.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The use of sustained release tablet formulation for non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin has shown its capability to protect the stomach lining from the adverse effect of gastric juice from the body. This study was carried out to evaluate the efficiency of sustained release matrix tablet formulation using ketoprofen as a model drug with different polymers concentration. The tablets were prepared by the wet granulation method using hydrophilic polymer (hydroxypropyl methylcellulose), hydrophobic pH dependent polymer (Eudragit L100-55) and independent polymer (Eudragit RD 100) as matrix forming retarding materials at 10%w/w, 20%w/w and 30%w/w. All formulations were compressed using 10 mm concave faced punches. The compressed tablets were evaluated for uniformity of weight, friability, hardness, thickness, % drug content and in vitro dissolution test with regard to BP 2007. The results showed that the drug release rate was found to be governed by the type and concentration of polymer in the matrix system. Generally, increasing the polymeric concentration in the matrix tablets will decrease the rate of drug release. When the polymers were compared at similar concentration using t50%, the difference in drug release was found to be statistically significant (p<0.05). Based on the in vitro drug dissolution studies, the hydrophobic pH dependent polymer (Eudragit L100-55) showed a better zero drug release profile compared to other polymers.
format	Article
author	Ibrahim Ijang, Mohd Cairul Iqbal Mohd Amin, Bukhori Abu Bakar,
spellingShingle	Ibrahim Ijang, Mohd Cairul Iqbal Mohd Amin, Bukhori Abu Bakar, Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets
author_facet	Ibrahim Ijang, Mohd Cairul Iqbal Mohd Amin, Bukhori Abu Bakar,
author_sort	Ibrahim Ijang,
title	Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets
title_short	Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets
title_full	Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets
title_fullStr	Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets
title_full_unstemmed	Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets
title_sort	physical properties and in vitro studies of sustained-release ketoprofen matrix tablets
publisher	Universiti Kebangsaan Malaysia
publishDate	2010
url	http://journalarticle.ukm.my/7398/ http://journalarticle.ukm.my/7398/ http://journalarticle.ukm.my/7398/1/01_Md_Yeaminhossain.pdf
first_indexed	2023-09-18T19:49:35Z
last_indexed	2023-09-18T19:49:35Z
_version_	1777406129607802880

Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets

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