Antidiabetic activity of aqueous extract of leptospermum flavescens in alloxan induced diabetic rats

Leptospermum flavescens, commonly known as ‘Gelam bukit’ has been used by the Malays as traditional plants in Malaysia for antidiabetic treatment. However, at this moment there is no scientific evidence and data available to validate such claim. In the present study, the aqueous extract of leaves an...

Full description

Bibliographic Details
Main Authors:	Asmawati Abd. Rahim, Jamaludin Mohamad, Zazali Alias
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2014
Online Access:	http://journalarticle.ukm.my/7663/ http://journalarticle.ukm.my/7663/ http://journalarticle.ukm.my/7663/1/02_Asmawati_Abd_Rahim.pdf

id	ukm-7663
recordtype	eprints
spelling	ukm-76632016-12-14T06:44:48Z http://journalarticle.ukm.my/7663/ Antidiabetic activity of aqueous extract of leptospermum flavescens in alloxan induced diabetic rats Asmawati Abd. Rahim, Jamaludin Mohamad, Zazali Alias, Leptospermum flavescens, commonly known as ‘Gelam bukit’ has been used by the Malays as traditional plants in Malaysia for antidiabetic treatment. However, at this moment there is no scientific evidence and data available to validate such claim. In the present study, the aqueous extract of leaves and stems were studied for its antidiabetic activity. The total phenols and flavonoids were determined and correlated with antidiabetic activity. The detection of aqueous leaves extract with LCMS/MS showed the presence of flavonoids aromadendrin glucoside, kaempferol rhamnoside, quercetin rhamnoside and vindoline. The extract has significantly inhibited glycogen phosphorylase at 85% with IC50 = 0.18 mg/mL. In the alloxan induced diabetic rats showed that extract at 500 mg/kg decreased significantly fasting plasma glucose level by 61.9% (p<0.001) on the 20th day as compared to diabetic control. The treatment with Leptospermum flavescens at 500 mg/kg showed that it decreased the total cholesterol and triglycerides but restored the HDL level. The high antidiabetic activity was correlated with high total phenol at 1.57±0.01 GAE/g and total flavonoids at 1.41±0.01 mg QE/g. Thus, the high antidiabetic activity of the aqueous leaves extract attributed due to the presence of aromadendron glucoside, kaempferol rhamnoside, quercetin rhamnoside and vindoline in aqueous extract of Leptospermum flavescens. Universiti Kebangsaan Malaysia 2014-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/7663/1/02_Asmawati_Abd_Rahim.pdf Asmawati Abd. Rahim, and Jamaludin Mohamad, and Zazali Alias, (2014) Antidiabetic activity of aqueous extract of leptospermum flavescens in alloxan induced diabetic rats. Sains Malaysiana, 43 (9). pp. 1295-1304. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Leptospermum flavescens, commonly known as ‘Gelam bukit’ has been used by the Malays as traditional plants in Malaysia for antidiabetic treatment. However, at this moment there is no scientific evidence and data available to validate such claim. In the present study, the aqueous extract of leaves and stems were studied for its antidiabetic activity. The total phenols and flavonoids were determined and correlated with antidiabetic activity. The detection of aqueous leaves extract with LCMS/MS showed the presence of flavonoids aromadendrin glucoside, kaempferol rhamnoside, quercetin rhamnoside and vindoline. The extract has significantly inhibited glycogen phosphorylase at 85% with IC50 = 0.18 mg/mL. In the alloxan induced diabetic rats showed that extract at 500 mg/kg decreased significantly fasting plasma glucose level by 61.9% (p<0.001) on the 20th day as compared to diabetic control. The treatment with Leptospermum flavescens at 500 mg/kg showed that it decreased the total cholesterol and triglycerides but restored the HDL level. The high antidiabetic activity was correlated with high total phenol at 1.57±0.01 GAE/g and total flavonoids at 1.41±0.01 mg QE/g. Thus, the high antidiabetic activity of the aqueous leaves extract attributed due to the presence of aromadendron glucoside, kaempferol rhamnoside, quercetin rhamnoside and vindoline in aqueous extract of Leptospermum flavescens.
format	Article
author	Asmawati Abd. Rahim, Jamaludin Mohamad, Zazali Alias,
spellingShingle	Asmawati Abd. Rahim, Jamaludin Mohamad, Zazali Alias, Antidiabetic activity of aqueous extract of leptospermum flavescens in alloxan induced diabetic rats
author_facet	Asmawati Abd. Rahim, Jamaludin Mohamad, Zazali Alias,
author_sort	Asmawati Abd. Rahim,
title	Antidiabetic activity of aqueous extract of leptospermum flavescens in alloxan induced diabetic rats
title_short	Antidiabetic activity of aqueous extract of leptospermum flavescens in alloxan induced diabetic rats
title_full	Antidiabetic activity of aqueous extract of leptospermum flavescens in alloxan induced diabetic rats
title_fullStr	Antidiabetic activity of aqueous extract of leptospermum flavescens in alloxan induced diabetic rats
title_full_unstemmed	Antidiabetic activity of aqueous extract of leptospermum flavescens in alloxan induced diabetic rats
title_sort	antidiabetic activity of aqueous extract of leptospermum flavescens in alloxan induced diabetic rats
publisher	Universiti Kebangsaan Malaysia
publishDate	2014
url	http://journalarticle.ukm.my/7663/ http://journalarticle.ukm.my/7663/ http://journalarticle.ukm.my/7663/1/02_Asmawati_Abd_Rahim.pdf
first_indexed	2023-09-18T19:50:17Z
last_indexed	2023-09-18T19:50:17Z
_version_	1777406173262118912

Antidiabetic activity of aqueous extract of leptospermum flavescens in alloxan induced diabetic rats

Similar Items