Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane

This was a prospective randomised study comparing carboxyhaemoglobin concentrations between low-flow anaesthesia (fresh gas flow 1.0 L/min) and minimal-flow anaesthesia (0.5 L/min) using desflurane. Sixty (ASA 1 or 2) adult patients undergoing elective surgery under general anaesthesia were randomly...

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Main Authors:	Nazarudin B., Khairulamir Z., Azarinah I., Jaafar MZ., Karis M., Esa K.
Format:	Article
Language:	English
Published:	Department of Surgery, UKM Medical Centre 2015
Online Access:	http://journalarticle.ukm.my/8651/ http://journalarticle.ukm.my/8651/ http://journalarticle.ukm.my/8651/1/04-Nazarudin%2520B%2520et%2520al..pdf

id	ukm-8651
recordtype	eprints
spelling	ukm-86512016-12-14T06:47:47Z http://journalarticle.ukm.my/8651/ Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane Nazarudin B., Khairulamir Z., Azarinah I., Jaafar MZ., Karis M., Esa K., This was a prospective randomised study comparing carboxyhaemoglobin concentrations between low-flow anaesthesia (fresh gas flow 1.0 L/min) and minimal-flow anaesthesia (0.5 L/min) using desflurane. Sixty (ASA 1 or 2) adult patients undergoing elective surgery under general anaesthesia were randomly allocated to receive either low-flow (Group 1) or minimal flow anaesthesia (Group 2). Venous blood samples for carboxyhaemoglobin levels were taken at baseline and at 10 mins intervals for 40 mins. Both groups showed significant increase in carboxyhaemoglobin concentrations within the first 10 mins when fresh gas flow of 4.0 L/min was used. Reduction in carboxyhemoglobin levels was seen after 20 mins of minimal or low flow anaesthesia. However, there was no significant difference in the magnitude of reduction of carboxyhemoglobin concentrations between the groups. The fractional inspired of oxygen (FiO2) showed no significant changes in either group. In conclusion, desflurane usage in anaesthesia with either low-flow or minimal-flow was not associated with increased carboxyhaemoglobin concentrations. Department of Surgery, UKM Medical Centre 2015-06-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/8651/1/04-Nazarudin%2520B%2520et%2520al..pdf Nazarudin B., and Khairulamir Z., and Azarinah I., and Jaafar MZ., and Karis M., and Esa K., (2015) Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane. Journal of Surgical Academia, vol.5 (1). pp. 19-23. ISSN 2231-7481 http://jsurgical.com
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	This was a prospective randomised study comparing carboxyhaemoglobin concentrations between low-flow anaesthesia (fresh gas flow 1.0 L/min) and minimal-flow anaesthesia (0.5 L/min) using desflurane. Sixty (ASA 1 or 2) adult patients undergoing elective surgery under general anaesthesia were randomly allocated to receive either low-flow (Group 1) or minimal flow anaesthesia (Group 2). Venous blood samples for carboxyhaemoglobin levels were taken at baseline and at 10 mins intervals for 40 mins. Both groups showed significant increase in carboxyhaemoglobin concentrations within the first 10 mins when fresh gas flow of 4.0 L/min was used. Reduction in carboxyhemoglobin levels was seen after 20 mins of minimal or low flow anaesthesia. However, there was no significant difference in the magnitude of reduction of carboxyhemoglobin concentrations between the groups. The fractional inspired of oxygen (FiO2) showed no significant changes in either group. In conclusion, desflurane usage in anaesthesia with either low-flow or minimal-flow was not associated with increased carboxyhaemoglobin concentrations.
format	Article
author	Nazarudin B., Khairulamir Z., Azarinah I., Jaafar MZ., Karis M., Esa K.,
spellingShingle	Nazarudin B., Khairulamir Z., Azarinah I., Jaafar MZ., Karis M., Esa K., Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane
author_facet	Nazarudin B., Khairulamir Z., Azarinah I., Jaafar MZ., Karis M., Esa K.,
author_sort	Nazarudin B.,
title	Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane
title_short	Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane
title_full	Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane
title_fullStr	Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane
title_full_unstemmed	Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane
title_sort	comparison of carboxyhaemoglobin concentrations between low-flow and minimal-flow anaesthesia with desflurane
publisher	Department of Surgery, UKM Medical Centre
publishDate	2015
url	http://journalarticle.ukm.my/8651/ http://journalarticle.ukm.my/8651/ http://journalarticle.ukm.my/8651/1/04-Nazarudin%2520B%2520et%2520al..pdf
first_indexed	2023-09-18T19:52:53Z
last_indexed	2023-09-18T19:52:53Z
_version_	1777406336993067008

Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane

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