High expression of cyclooxygenase-2 in high grade human prostate adenocarcinoma

Inflammation plays an important role to the process of prostate carcinogenesis by increasing the rate of cell proliferation, which contributes to an aggressive tumour phenotype. Cyclooxygenase-2 (COX-2) has been found overexpressed in various types of cancer cells including prostate. The aim of this...

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Main Authors:	Mohd Rohaizad Md Roduan, Norhafizah Mohtarrudin, Chong, Pei Pei, Malina Osman, Noraini Mohd Dusa
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2015
Online Access:	http://journalarticle.ukm.my/8948/ http://journalarticle.ukm.my/8948/ http://journalarticle.ukm.my/8948/1/12_Mohd_Rohaizad_Md_Roduan.pdf

id	ukm-8948
recordtype	eprints
spelling	ukm-89482016-12-14T06:48:31Z http://journalarticle.ukm.my/8948/ High expression of cyclooxygenase-2 in high grade human prostate adenocarcinoma Mohd Rohaizad Md Roduan, Norhafizah Mohtarrudin, Chong, Pei Pei Malina Osman, Noraini Mohd Dusa, Inflammation plays an important role to the process of prostate carcinogenesis by increasing the rate of cell proliferation, which contributes to an aggressive tumour phenotype. Cyclooxygenase-2 (COX-2) has been found overexpressed in various types of cancer cells including prostate. The aim of this study was to investigate the COX-2 expressions in different types of human prostate tissues. Paraffin-embedded prostate tissues from 263 samples were examined for the expression of COX-2 marker by immunohistochemistry method. COX-2 was found highly expressed in prostate adenocarcinoma (p=0.001) as compared to benign and normal tissues. The score of COX-2 expressions in most of normal prostate was weak 49 (77.8%), while only 16 (16%) of BPH showed strong expression. 56 cases (56%) prostate cancer showed strong COX-2 expression. Prostate cancer cases showed significant differences in staining patterns as tumour grade increased. In addition, COX-2 expression was significantly correlated with Gleason score in cancerous tissues. This study suggests that COX-2 overexpression is associated with prostate cancer and higher grade tumour. Universiti Kebangsaan Malaysia 2015-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/8948/1/12_Mohd_Rohaizad_Md_Roduan.pdf Mohd Rohaizad Md Roduan, and Norhafizah Mohtarrudin, and Chong, Pei Pei and Malina Osman, and Noraini Mohd Dusa, (2015) High expression of cyclooxygenase-2 in high grade human prostate adenocarcinoma. Sains Malaysiana, 44 (5). pp. 727-733. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid44bil5_2015/KandunganJilid44Bil5_2015.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Inflammation plays an important role to the process of prostate carcinogenesis by increasing the rate of cell proliferation, which contributes to an aggressive tumour phenotype. Cyclooxygenase-2 (COX-2) has been found overexpressed in various types of cancer cells including prostate. The aim of this study was to investigate the COX-2 expressions in different types of human prostate tissues. Paraffin-embedded prostate tissues from 263 samples were examined for the expression of COX-2 marker by immunohistochemistry method. COX-2 was found highly expressed in prostate adenocarcinoma (p=0.001) as compared to benign and normal tissues. The score of COX-2 expressions in most of normal prostate was weak 49 (77.8%), while only 16 (16%) of BPH showed strong expression. 56 cases (56%) prostate cancer showed strong COX-2 expression. Prostate cancer cases showed significant differences in staining patterns as tumour grade increased. In addition, COX-2 expression was significantly correlated with Gleason score in cancerous tissues. This study suggests that COX-2 overexpression is associated with prostate cancer and higher grade tumour.
format	Article
author	Mohd Rohaizad Md Roduan, Norhafizah Mohtarrudin, Chong, Pei Pei Malina Osman, Noraini Mohd Dusa,
spellingShingle	Mohd Rohaizad Md Roduan, Norhafizah Mohtarrudin, Chong, Pei Pei Malina Osman, Noraini Mohd Dusa, High expression of cyclooxygenase-2 in high grade human prostate adenocarcinoma
author_facet	Mohd Rohaizad Md Roduan, Norhafizah Mohtarrudin, Chong, Pei Pei Malina Osman, Noraini Mohd Dusa,
author_sort	Mohd Rohaizad Md Roduan,
title	High expression of cyclooxygenase-2 in high grade human prostate adenocarcinoma
title_short	High expression of cyclooxygenase-2 in high grade human prostate adenocarcinoma
title_full	High expression of cyclooxygenase-2 in high grade human prostate adenocarcinoma
title_fullStr	High expression of cyclooxygenase-2 in high grade human prostate adenocarcinoma
title_full_unstemmed	High expression of cyclooxygenase-2 in high grade human prostate adenocarcinoma
title_sort	high expression of cyclooxygenase-2 in high grade human prostate adenocarcinoma
publisher	Universiti Kebangsaan Malaysia
publishDate	2015
url	http://journalarticle.ukm.my/8948/ http://journalarticle.ukm.my/8948/ http://journalarticle.ukm.my/8948/1/12_Mohd_Rohaizad_Md_Roduan.pdf
first_indexed	2023-09-18T19:53:34Z
last_indexed	2023-09-18T19:53:34Z
_version_	1777406379849416704

High expression of cyclooxygenase-2 in high grade human prostate adenocarcinoma

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