Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi

This study was carried out to determine the potential of technetium-99m pertechnetate Human Immunoglobulin G (***Tc.HIgG) as a radiopharmaceutical agent in the detection of inflammation site. Reduced HLgG antibody was found to be stabled at the optimal storage temperatures of -70°C and 0°C and deter...

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Main Authors:	Rosnani Hashim, Shaharuddin Mohd, Ang, Woan Tze, Wan Hamirul Bahrin Wan Kamal, Shahrin Abdul Hamid
Format:	Article
Language:	English
Published:	penerbit ukm 2003
Online Access:	http://journalarticle.ukm.my/947/ http://journalarticle.ukm.my/947/ http://journalarticle.ukm.my/947/1/jurnal3.pdf

id	ukm-947
recordtype	eprints
spelling	ukm-9472016-12-14T06:28:23Z http://journalarticle.ukm.my/947/ Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi Rosnani Hashim, Shaharuddin Mohd, Ang, Woan Tze Wan Hamirul Bahrin Wan Kamal, Shahrin Abdul Hamid, This study was carried out to determine the potential of technetium-99m pertechnetate Human Immunoglobulin G (*Tc.HIgG) as a radiopharmaceutical agent in the detection of inflammation site. Reduced HLgG antibody was found to be stabled at the optimal storage temperatures of -70°C and 0°C and deteriorated at 2 - N°C. The percentage of labeling of HIgG with Tc obtained was more than 95%. Biodistribution of Tc-HIgG was studied by using Sprague Dawley rats which were injected intramuscularly with turpentine to induce localized inflammation. The biodistribution of Tc-HIgG was determined by using immunosintigraphy (scanning) and kill and count method. Immunosintigram obtained after 4 hours post injection showed the clearest image of Tc-HIgG biodistribution in the inflamed muscle. The cut and count method also indicated that uptake of Tc-HIgG by the inflamed muscle was highest after 4 hours post injection. The pattern of Tc localization was different from Tc-HIgG. Imaging of inflamed cells using radiopharmaceutical **Tc-HIgG, Possesses the potential to be used in the diagnosis of infection’inflammation such as in cancer or immunocompromised patients and in assessing patient’s response to the therapy of inflammatory diseases. penerbit ukm 2003-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/947/1/jurnal3.pdf Rosnani Hashim, and Shaharuddin Mohd, and Ang, Woan Tze and Wan Hamirul Bahrin Wan Kamal, and Shahrin Abdul Hamid, (2003) Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi. Jurnal Sains Kesihatan Malaysia, 1 . pp. 61-72. ISSN 1675-8161 http://www.fskb.ukm.my/fskbold/jurnal
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	This study was carried out to determine the potential of technetium-99m pertechnetate Human Immunoglobulin G (*Tc.HIgG) as a radiopharmaceutical agent in the detection of inflammation site. Reduced HLgG antibody was found to be stabled at the optimal storage temperatures of -70°C and 0°C and deteriorated at 2 - N°C. The percentage of labeling of HIgG with Tc obtained was more than 95%. Biodistribution of Tc-HIgG was studied by using Sprague Dawley rats which were injected intramuscularly with turpentine to induce localized inflammation. The biodistribution of Tc-HIgG was determined by using immunosintigraphy (scanning) and kill and count method. Immunosintigram obtained after 4 hours post injection showed the clearest image of Tc-HIgG biodistribution in the inflamed muscle. The cut and count method also indicated that uptake of Tc-HIgG by the inflamed muscle was highest after 4 hours post injection. The pattern of Tc localization was different from Tc-HIgG. Imaging of inflamed cells using radiopharmaceutical **Tc-HIgG, Possesses the potential to be used in the diagnosis of infection’inflammation such as in cancer or immunocompromised patients and in assessing patient’s response to the therapy of inflammatory diseases.
format	Article
author	Rosnani Hashim, Shaharuddin Mohd, Ang, Woan Tze Wan Hamirul Bahrin Wan Kamal, Shahrin Abdul Hamid,
spellingShingle	Rosnani Hashim, Shaharuddin Mohd, Ang, Woan Tze Wan Hamirul Bahrin Wan Kamal, Shahrin Abdul Hamid, Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi
author_facet	Rosnani Hashim, Shaharuddin Mohd, Ang, Woan Tze Wan Hamirul Bahrin Wan Kamal, Shahrin Abdul Hamid,
author_sort	Rosnani Hashim,
title	Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi
title_short	Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi
title_full	Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi
title_fullStr	Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi
title_full_unstemmed	Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi
title_sort	teknetium-99 perteknetat imunoglobulin g manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi
publisher	penerbit ukm
publishDate	2003
url	http://journalarticle.ukm.my/947/ http://journalarticle.ukm.my/947/ http://journalarticle.ukm.my/947/1/jurnal3.pdf
first_indexed	2023-09-18T19:31:58Z
last_indexed	2023-09-18T19:31:58Z
_version_	1777405021514629120

Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi

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