Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats

Nicotine has been identified as one of the causal factor for oxidative stress, hypertension and hyperlipidemia. Roselle has been widely studied for its potential as an antioxidant, antihyperlipidemic and antihypertensive. However, no studies have been done to investigate if roselle could diminish...

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Main Authors:	Satirah Zainalabidin, Siti Nor Farhanah Sh Nor Shahidin, Siti Balkis Budin
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2016
Online Access:	http://journalarticle.ukm.my/9674/ http://journalarticle.ukm.my/9674/ http://journalarticle.ukm.my/9674/1/07_Satirah_Zainal_Abidin.pdf

id	ukm-9674
recordtype	eprints
spelling	ukm-96742016-12-14T06:50:31Z http://journalarticle.ukm.my/9674/ Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats Satirah Zainalabidin, Siti Nor Farhanah Sh Nor Shahidin, Siti Balkis Budin, Nicotine has been identified as one of the causal factor for oxidative stress, hypertension and hyperlipidemia. Roselle has been widely studied for its potential as an antioxidant, antihyperlipidemic and antihypertensive. However, no studies have been done to investigate if roselle could diminish the oxidative stress caused by nicotine which could further lead to cardiac damages. Thus, this study was aimed to investigate the effect of roselle extract (HSE) on blood pressure, serum lipid profile, oxidative stress marker levels and histological changes to the heart in nicotine-treated rats. A total of 21 Sprague-Dawley rats were randomly divided into 3 groups (n=7 per group): Control group received normal saline (0.5 mL/day, i.p); nicotine group received 0.6 mg/kg/BW nicotine (i.p); and treated group received 100 mg/kg/b.w HSE through oral force feeding followed with 0.6 mg/kg/b.w nicotine (i.p) for 21 consecutive days. The results showed that HSE significantly (p>0.05) reduced the heart rate but no effect to the blood pressure. For lipid profile study, HSE increased the high-density lipoprotein (HDL) concentration significantly (p<0.05) in rats given with nicotine, without any significant changes in total cholesterol, triglyceride and low-density ipoprotein (LDL) concentration. Besides, HSE treatment was also found to reverse malondialdehyde (MDA) level, superoxide dimustase (SOD) enzyme activity and protein concentration significantly (p<0.05) in nicotine-treated rats. In summary, these results indicated that HSE is an effective antioxidant against oxidative damage in heart caused by nicotine, but not as antihyperlipidemic and antihypertensive agent in this rat model. Universiti Kebangsaan Malaysia 2016-02 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9674/1/07_Satirah_Zainal_Abidin.pdf Satirah Zainalabidin, and Siti Nor Farhanah Sh Nor Shahidin, and Siti Balkis Budin, (2016) Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats. Sains Malaysiana, 45 (2). pp. 207-214. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid45bil2_2016/KandunganJilid45Bil2_2016.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Nicotine has been identified as one of the causal factor for oxidative stress, hypertension and hyperlipidemia. Roselle has been widely studied for its potential as an antioxidant, antihyperlipidemic and antihypertensive. However, no studies have been done to investigate if roselle could diminish the oxidative stress caused by nicotine which could further lead to cardiac damages. Thus, this study was aimed to investigate the effect of roselle extract (HSE) on blood pressure, serum lipid profile, oxidative stress marker levels and histological changes to the heart in nicotine-treated rats. A total of 21 Sprague-Dawley rats were randomly divided into 3 groups (n=7 per group): Control group received normal saline (0.5 mL/day, i.p); nicotine group received 0.6 mg/kg/BW nicotine (i.p); and treated group received 100 mg/kg/b.w HSE through oral force feeding followed with 0.6 mg/kg/b.w nicotine (i.p) for 21 consecutive days. The results showed that HSE significantly (p>0.05) reduced the heart rate but no effect to the blood pressure. For lipid profile study, HSE increased the high-density lipoprotein (HDL) concentration significantly (p<0.05) in rats given with nicotine, without any significant changes in total cholesterol, triglyceride and low-density ipoprotein (LDL) concentration. Besides, HSE treatment was also found to reverse malondialdehyde (MDA) level, superoxide dimustase (SOD) enzyme activity and protein concentration significantly (p<0.05) in nicotine-treated rats. In summary, these results indicated that HSE is an effective antioxidant against oxidative damage in heart caused by nicotine, but not as antihyperlipidemic and antihypertensive agent in this rat model.
format	Article
author	Satirah Zainalabidin, Siti Nor Farhanah Sh Nor Shahidin, Siti Balkis Budin,
spellingShingle	Satirah Zainalabidin, Siti Nor Farhanah Sh Nor Shahidin, Siti Balkis Budin, Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats
author_facet	Satirah Zainalabidin, Siti Nor Farhanah Sh Nor Shahidin, Siti Balkis Budin,
author_sort	Satirah Zainalabidin,
title	Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats
title_short	Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats
title_full	Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats
title_fullStr	Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats
title_full_unstemmed	Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats
title_sort	hibiscus sabdariffa linn. (roselle) protects against nicotine-induced heart damage in rats
publisher	Universiti Kebangsaan Malaysia
publishDate	2016
url	http://journalarticle.ukm.my/9674/ http://journalarticle.ukm.my/9674/ http://journalarticle.ukm.my/9674/1/07_Satirah_Zainal_Abidin.pdf
first_indexed	2023-09-18T19:55:23Z
last_indexed	2023-09-18T19:55:23Z
_version_	1777406494664294400

Hibiscus sabdariffa Linn. (Roselle) protects against nicotine-induced heart damage in rats

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