Synthesis, characterization and antibacterial activity of mono-, di- and tri-tosylate of glycerol

Glycerol is a valuable co-product from oleochemical industry such as from fatty acid and biodiesel production. By having three hydroxyl groups in its molecule, glycerol can undergo chemical modifications that lead to many possible applications. This paper reports the tosylation process of glycerol w...

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Main Authors:	Yusrabbil Amiyati Yusof, Azhar Ariffin A.
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2016
Online Access:	http://journalarticle.ukm.my/9753/ http://journalarticle.ukm.my/9753/ http://journalarticle.ukm.my/9753/1/16_Yusrabbil_Amiyati_Yusof.pdf

id	ukm-9753
recordtype	eprints
spelling	ukm-97532016-12-14T06:50:44Z http://journalarticle.ukm.my/9753/ Synthesis, characterization and antibacterial activity of mono-, di- and tri-tosylate of glycerol Yusrabbil Amiyati Yusof, Azhar Ariffin A., Glycerol is a valuable co-product from oleochemical industry such as from fatty acid and biodiesel production. By having three hydroxyl groups in its molecule, glycerol can undergo chemical modifications that lead to many possible applications. This paper reports the tosylation process of glycerol with para-toluenesulfonyl chloride (p-TsCl). Reaction of glycerol with p-TsCl in the presence of a base produced mono-, di- and tri-tosylate of glycerol even though the reaction was carried out at the mole ratio of 1.2:1.0 of glycerol to p-TsCl. The compounds were successfully isolated and characterized. Mono-, di- and tri-tosylate of glycerol exhibited inhibitory activity against Staphylococcus aureus (gram positive bacteria) and Pseudomonas aeruginosa (gram negative bacteria). Penerbit Universiti Kebangsaan Malaysia 2016-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9753/1/16_Yusrabbil_Amiyati_Yusof.pdf Yusrabbil Amiyati Yusof, and Azhar Ariffin A., (2016) Synthesis, characterization and antibacterial activity of mono-, di- and tri-tosylate of glycerol. Sains Malaysiana, 45 (4). pp. 621-625. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid45bil4_2016/KandunganJilid45Bil4_2016.htm
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Glycerol is a valuable co-product from oleochemical industry such as from fatty acid and biodiesel production. By having three hydroxyl groups in its molecule, glycerol can undergo chemical modifications that lead to many possible applications. This paper reports the tosylation process of glycerol with para-toluenesulfonyl chloride (p-TsCl). Reaction of glycerol with p-TsCl in the presence of a base produced mono-, di- and tri-tosylate of glycerol even though the reaction was carried out at the mole ratio of 1.2:1.0 of glycerol to p-TsCl. The compounds were successfully isolated and characterized. Mono-, di- and tri-tosylate of glycerol exhibited inhibitory activity against Staphylococcus aureus (gram positive bacteria) and Pseudomonas aeruginosa (gram negative bacteria).
format	Article
author	Yusrabbil Amiyati Yusof, Azhar Ariffin A.,
spellingShingle	Yusrabbil Amiyati Yusof, Azhar Ariffin A., Synthesis, characterization and antibacterial activity of mono-, di- and tri-tosylate of glycerol
author_facet	Yusrabbil Amiyati Yusof, Azhar Ariffin A.,
author_sort	Yusrabbil Amiyati Yusof,
title	Synthesis, characterization and antibacterial activity of mono-, di- and tri-tosylate of glycerol
title_short	Synthesis, characterization and antibacterial activity of mono-, di- and tri-tosylate of glycerol
title_full	Synthesis, characterization and antibacterial activity of mono-, di- and tri-tosylate of glycerol
title_fullStr	Synthesis, characterization and antibacterial activity of mono-, di- and tri-tosylate of glycerol
title_full_unstemmed	Synthesis, characterization and antibacterial activity of mono-, di- and tri-tosylate of glycerol
title_sort	synthesis, characterization and antibacterial activity of mono-, di- and tri-tosylate of glycerol
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2016
url	http://journalarticle.ukm.my/9753/ http://journalarticle.ukm.my/9753/ http://journalarticle.ukm.my/9753/1/16_Yusrabbil_Amiyati_Yusof.pdf
first_indexed	2023-09-18T19:55:36Z
last_indexed	2023-09-18T19:55:36Z
_version_	1777406508108087296

Synthesis, characterization and antibacterial activity of mono-, di- and tri-tosylate of glycerol

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