Adverse drug reaction with midazolam use in Emergency Department

Midazolam is one of the most commonly used drugs for sedation in Emergency Department (ED). This was a retrospective study conducted on 380 patients from December 2012 to May 2014 in ED of Universiti Kebangsaan Malaysia Medical Centre (UKMMC). The objective was to elicit the frequency of side effect...

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Main Authors:	Nik Azlan Nik Muhamad, Ahmad Khaldun Ismail, Hilwani Kaharuddin, Miao, Ching Heng, Qamarul Ariffin S, Syazwani Azwa S, Nazurah MS
Format:	Article
Language:	English
Published:	Fakulti Perubatan, UKM 2016
Online Access:	http://journalarticle.ukm.my/9782/ http://journalarticle.ukm.my/9782/ http://journalarticle.ukm.my/9782/1/2._NikMuhammad_et_al.pdf

id	ukm-9782
recordtype	eprints
spelling	ukm-97822016-12-14T06:50:49Z http://journalarticle.ukm.my/9782/ Adverse drug reaction with midazolam use in Emergency Department Nik Azlan Nik Muhamad, Ahmad Khaldun Ismail, Hilwani Kaharuddin, Miao, Ching Heng Qamarul Ariffin S, Syazwani Azwa S, Nazurah MS, Midazolam is one of the most commonly used drugs for sedation in Emergency Department (ED). This was a retrospective study conducted on 380 patients from December 2012 to May 2014 in ED of Universiti Kebangsaan Malaysia Medical Centre (UKMMC). The objective was to elicit the frequency of side effects and correlation to various factors i.e. socio-demography, co-morbidities, age groups and underlying illnesses. Out of 380 patients, 35 patients experienced side effects (20 patients with midazolam alone, 15 patients with combination of drugs). The average age was 42 years and the average dose of midazolam was 3.5mg. The most common other drug combined was fentanyl. The overall complication rate for midazolam was 5.3%. The most common side effect recorded was excessive somnolence (1.6%). Other side effects included local skin reactions (1.1%), vomiting (0.8%), headache (0.8%) and hypotension (0.5%). There was no significant association between the socio-demographic factors and drugs combination with the side effects of midazolam on patients. It was concluded that midazolam was a safe drug due to absence of any life-threatening side effects. There are possibilities that most side effects recorded could be caused by other comfounding factors e.g. underlying injuries or disease and combination with other drugs. Fakulti Perubatan, UKM 2016 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9782/1/2._NikMuhammad_et_al.pdf Nik Azlan Nik Muhamad, and Ahmad Khaldun Ismail, and Hilwani Kaharuddin, and Miao, Ching Heng and Qamarul Ariffin S, and Syazwani Azwa S, and Nazurah MS, (2016) Adverse drug reaction with midazolam use in Emergency Department. Medicine & Health, 11 (1). pp. 2-10. ISSN 1823-2140 http://www.medicineandhealthukm.com/toc
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Midazolam is one of the most commonly used drugs for sedation in Emergency Department (ED). This was a retrospective study conducted on 380 patients from December 2012 to May 2014 in ED of Universiti Kebangsaan Malaysia Medical Centre (UKMMC). The objective was to elicit the frequency of side effects and correlation to various factors i.e. socio-demography, co-morbidities, age groups and underlying illnesses. Out of 380 patients, 35 patients experienced side effects (20 patients with midazolam alone, 15 patients with combination of drugs). The average age was 42 years and the average dose of midazolam was 3.5mg. The most common other drug combined was fentanyl. The overall complication rate for midazolam was 5.3%. The most common side effect recorded was excessive somnolence (1.6%). Other side effects included local skin reactions (1.1%), vomiting (0.8%), headache (0.8%) and hypotension (0.5%). There was no significant association between the socio-demographic factors and drugs combination with the side effects of midazolam on patients. It was concluded that midazolam was a safe drug due to absence of any life-threatening side effects. There are possibilities that most side effects recorded could be caused by other comfounding factors e.g. underlying injuries or disease and combination with other drugs.
format	Article
author	Nik Azlan Nik Muhamad, Ahmad Khaldun Ismail, Hilwani Kaharuddin, Miao, Ching Heng Qamarul Ariffin S, Syazwani Azwa S, Nazurah MS,
spellingShingle	Nik Azlan Nik Muhamad, Ahmad Khaldun Ismail, Hilwani Kaharuddin, Miao, Ching Heng Qamarul Ariffin S, Syazwani Azwa S, Nazurah MS, Adverse drug reaction with midazolam use in Emergency Department
author_facet	Nik Azlan Nik Muhamad, Ahmad Khaldun Ismail, Hilwani Kaharuddin, Miao, Ching Heng Qamarul Ariffin S, Syazwani Azwa S, Nazurah MS,
author_sort	Nik Azlan Nik Muhamad,
title	Adverse drug reaction with midazolam use in Emergency Department
title_short	Adverse drug reaction with midazolam use in Emergency Department
title_full	Adverse drug reaction with midazolam use in Emergency Department
title_fullStr	Adverse drug reaction with midazolam use in Emergency Department
title_full_unstemmed	Adverse drug reaction with midazolam use in Emergency Department
title_sort	adverse drug reaction with midazolam use in emergency department
publisher	Fakulti Perubatan, UKM
publishDate	2016
url	http://journalarticle.ukm.my/9782/ http://journalarticle.ukm.my/9782/ http://journalarticle.ukm.my/9782/1/2._NikMuhammad_et_al.pdf
first_indexed	2023-09-18T19:55:43Z
last_indexed	2023-09-18T19:55:43Z
_version_	1777406515000377344

Adverse drug reaction with midazolam use in Emergency Department

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