Retinal nerve fibre layer thickness changes after pan-retinal photocoagulation in diabetic retinopathy

Diabetic retinopathy is a disease involving microangiopathic changes in response to chronic hyperglycaemia and pan retinal photocoagulation (PRP) is currently the mainstay of treatment for proliferative retinopathy. In the present study, we evaluated the effect of pan retinal photocoagulation (PRP)...

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Main Authors:	Goh, SY, Ropilah Abdul Rahman, Othmaliza Othman, Mushawiahti Mustapha
Format:	Article
Language:	English
Published:	Faculty of Medicine, UKM Medical Centre 2016
Online Access:	http://journalarticle.ukm.my/9828/ http://journalarticle.ukm.my/9828/ http://journalarticle.ukm.my/9828/1/2._Goh_et_al..pdf

id	ukm-9828
recordtype	eprints
spelling	ukm-98282016-12-14T06:50:58Z http://journalarticle.ukm.my/9828/ Retinal nerve fibre layer thickness changes after pan-retinal photocoagulation in diabetic retinopathy Goh, SY Ropilah Abdul Rahman, Othmaliza Othman, Mushawiahti Mustapha, Diabetic retinopathy is a disease involving microangiopathic changes in response to chronic hyperglycaemia and pan retinal photocoagulation (PRP) is currently the mainstay of treatment for proliferative retinopathy. In the present study, we evaluated the effect of pan retinal photocoagulation (PRP) on retinal nerve fibre layer (RNFL) thickness in patients with diabetic retinopathy using optical coherence tomography (OCT). This was a prospective longitudinal study. Patients with Type 2 diabetes mellitus with proliferative diabetic retinopathy (PDR) or very severe non-(N)PDR requiring laser treatment were included in the study. PRP was performed by a single trained personnel. Peripapillary RNFL located 3.4 mm around the optic disc was evaluated using time-domain OCT. Examination was performed before treatment, and 2 and 4 months after laser treatment. In total, 39 subjects (39 eyes) were recruited into this study. Twenty-nine patients had PDR and 10 had very severe NPDR. Mean age was 54.97 ± 8.38 years. Male and female genders were almost equally distributed with 18 males and 21 females. Median thickness of average RNFL at baseline was 108.8 um (interquartile range [IQR] 35.3). At two months post-procedure, average RNFL thickness significantly increased to 117.4 (IQR 28.6; P = 0.006). Although, other quadrants revealed a similar trend of increasing thickness at two months but it was not significant. At 4 months post-laser treatment, RNFL thickness in all quadrants reduced to baseline levels with insignificant changes of thickness compared to prior to laser treatment. There was also no significant association between changes in RNFL thickness and HbA1c levels (P = 0.77). In conclusion, PRP causes transient thickening of the RNFL which recovers within 4 months post-laser treatment. At the same time, poor sugar control has no direct influence on the RNFL changes after PRP. Faculty of Medicine, UKM Medical Centre 2016 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9828/1/2._Goh_et_al..pdf Goh, SY and Ropilah Abdul Rahman, and Othmaliza Othman, and Mushawiahti Mustapha, (2016) Retinal nerve fibre layer thickness changes after pan-retinal photocoagulation in diabetic retinopathy. Journal of Surgical Academia, 6 (1). pp. 4-9. ISSN 2231-7481 http://jsurgacad.com/toc/6/1
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Diabetic retinopathy is a disease involving microangiopathic changes in response to chronic hyperglycaemia and pan retinal photocoagulation (PRP) is currently the mainstay of treatment for proliferative retinopathy. In the present study, we evaluated the effect of pan retinal photocoagulation (PRP) on retinal nerve fibre layer (RNFL) thickness in patients with diabetic retinopathy using optical coherence tomography (OCT). This was a prospective longitudinal study. Patients with Type 2 diabetes mellitus with proliferative diabetic retinopathy (PDR) or very severe non-(N)PDR requiring laser treatment were included in the study. PRP was performed by a single trained personnel. Peripapillary RNFL located 3.4 mm around the optic disc was evaluated using time-domain OCT. Examination was performed before treatment, and 2 and 4 months after laser treatment. In total, 39 subjects (39 eyes) were recruited into this study. Twenty-nine patients had PDR and 10 had very severe NPDR. Mean age was 54.97 ± 8.38 years. Male and female genders were almost equally distributed with 18 males and 21 females. Median thickness of average RNFL at baseline was 108.8 um (interquartile range [IQR] 35.3). At two months post-procedure, average RNFL thickness significantly increased to 117.4 (IQR 28.6; P = 0.006). Although, other quadrants revealed a similar trend of increasing thickness at two months but it was not significant. At 4 months post-laser treatment, RNFL thickness in all quadrants reduced to baseline levels with insignificant changes of thickness compared to prior to laser treatment. There was also no significant association between changes in RNFL thickness and HbA1c levels (P = 0.77). In conclusion, PRP causes transient thickening of the RNFL which recovers within 4 months post-laser treatment. At the same time, poor sugar control has no direct influence on the RNFL changes after PRP.
format	Article
author	Goh, SY Ropilah Abdul Rahman, Othmaliza Othman, Mushawiahti Mustapha,
spellingShingle	Goh, SY Ropilah Abdul Rahman, Othmaliza Othman, Mushawiahti Mustapha, Retinal nerve fibre layer thickness changes after pan-retinal photocoagulation in diabetic retinopathy
author_facet	Goh, SY Ropilah Abdul Rahman, Othmaliza Othman, Mushawiahti Mustapha,
author_sort	Goh, SY
title	Retinal nerve fibre layer thickness changes after pan-retinal photocoagulation in diabetic retinopathy
title_short	Retinal nerve fibre layer thickness changes after pan-retinal photocoagulation in diabetic retinopathy
title_full	Retinal nerve fibre layer thickness changes after pan-retinal photocoagulation in diabetic retinopathy
title_fullStr	Retinal nerve fibre layer thickness changes after pan-retinal photocoagulation in diabetic retinopathy
title_full_unstemmed	Retinal nerve fibre layer thickness changes after pan-retinal photocoagulation in diabetic retinopathy
title_sort	retinal nerve fibre layer thickness changes after pan-retinal photocoagulation in diabetic retinopathy
publisher	Faculty of Medicine, UKM Medical Centre
publishDate	2016
url	http://journalarticle.ukm.my/9828/ http://journalarticle.ukm.my/9828/ http://journalarticle.ukm.my/9828/1/2._Goh_et_al..pdf
first_indexed	2023-09-18T19:55:49Z
last_indexed	2023-09-18T19:55:49Z
_version_	1777406521648349184

Retinal nerve fibre layer thickness changes after pan-retinal photocoagulation in diabetic retinopathy

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