Perbandingan sifat-sifat pentabletan Radix Glycyrrhizae dengan eksipien komersil secara pemampatan terus

The objectives of this study were to investigate the physicochemical properties of Radix Glycyrrhizae as an excipient in tableting by using direct compression method and to compare it with other commercial excipients i.e. lactose, microcrystalline cellulose (MCC) and calcium lactate pentahydrate (Pu...

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Main Authors:	Mohd Cairul Iqbal Mohd Amin, Widianingsih
Format:	Article
Language:	English
Published:	penerbit ukm 2005
Online Access:	http://journalarticle.ukm.my/988/ http://journalarticle.ukm.my/988/ http://journalarticle.ukm.my/988/1/jurnal41.pdf

id	ukm-988
recordtype	eprints
spelling	ukm-9882016-12-14T06:28:30Z http://journalarticle.ukm.my/988/ Perbandingan sifat-sifat pentabletan Radix Glycyrrhizae dengan eksipien komersil secara pemampatan terus Mohd Cairul Iqbal Mohd Amin, Widianingsih, The objectives of this study were to investigate the physicochemical properties of Radix Glycyrrhizae as an excipient in tableting by using direct compression method and to compare it with other commercial excipients i.e. lactose, microcrystalline cellulose (MCC) and calcium lactate pentahydrate (Puracal). Particle sizes of all samples were limited to 200-250 μm. Scanning electron microscope showed that the particles of Radix Glycyrrhizae possessed a variety of uneven sizes and shapes similar to those of lactose whereas MCC particles were more needle-like structure while Puracal particles were more spherical and porous. The ability of all samples to be compressed, the true density of each sample particle, the effect of humidity on the stress relaxation of the samples and the porosity of the tablets were investigated. The bonding properties of the samples in tablet form were evaluated by measuring the tensile strength through diametral compression. The true densities of Radix Glycyrrhizae,lactose, MCC and Puracal were 1.5746, 1.5476, 1.6654 and 1.3506 g/cc, respectively. Radix Glycyrrhizae was found to have moderate compressibility and compactibility properties similar to lactose unlike Puracal and MCC which were far better compressed. The study on the effect of humidity on stress relaxation of the tablets showed that all samples were affected by changes in temperature. Heckel analysis on the samples suggested that Radix Glycyrrhizae showed plastic deformation properties similar to MCC while lactose and Puracal were of brittle fracture properties. In conclusion, Radix Glycyrrhizae could be compressed into tablet by using the direct compression method and its properties as an excipient was comparable to the other commercial excipients penerbit ukm 2005 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/988/1/jurnal41.pdf Mohd Cairul Iqbal Mohd Amin, and Widianingsih, (2005) Perbandingan sifat-sifat pentabletan Radix Glycyrrhizae dengan eksipien komersil secara pemampatan terus. Jurnal Sains Kesihatan Malaysia, 3 (2). pp. 55-66. ISSN 1675-8161 http://www.fskb.ukm.my/fskbold/jurnal
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The objectives of this study were to investigate the physicochemical properties of Radix Glycyrrhizae as an excipient in tableting by using direct compression method and to compare it with other commercial excipients i.e. lactose, microcrystalline cellulose (MCC) and calcium lactate pentahydrate (Puracal). Particle sizes of all samples were limited to 200-250 μm. Scanning electron microscope showed that the particles of Radix Glycyrrhizae possessed a variety of uneven sizes and shapes similar to those of lactose whereas MCC particles were more needle-like structure while Puracal particles were more spherical and porous. The ability of all samples to be compressed, the true density of each sample particle, the effect of humidity on the stress relaxation of the samples and the porosity of the tablets were investigated. The bonding properties of the samples in tablet form were evaluated by measuring the tensile strength through diametral compression. The true densities of Radix Glycyrrhizae,lactose, MCC and Puracal were 1.5746, 1.5476, 1.6654 and 1.3506 g/cc, respectively. Radix Glycyrrhizae was found to have moderate compressibility and compactibility properties similar to lactose unlike Puracal and MCC which were far better compressed. The study on the effect of humidity on stress relaxation of the tablets showed that all samples were affected by changes in temperature. Heckel analysis on the samples suggested that Radix Glycyrrhizae showed plastic deformation properties similar to MCC while lactose and Puracal were of brittle fracture properties. In conclusion, Radix Glycyrrhizae could be compressed into tablet by using the direct compression method and its properties as an excipient was comparable to the other commercial excipients
format	Article
author	Mohd Cairul Iqbal Mohd Amin, Widianingsih,
spellingShingle	Mohd Cairul Iqbal Mohd Amin, Widianingsih, Perbandingan sifat-sifat pentabletan Radix Glycyrrhizae dengan eksipien komersil secara pemampatan terus
author_facet	Mohd Cairul Iqbal Mohd Amin, Widianingsih,
author_sort	Mohd Cairul Iqbal Mohd Amin,
title	Perbandingan sifat-sifat pentabletan Radix Glycyrrhizae dengan eksipien komersil secara pemampatan terus
title_short	Perbandingan sifat-sifat pentabletan Radix Glycyrrhizae dengan eksipien komersil secara pemampatan terus
title_full	Perbandingan sifat-sifat pentabletan Radix Glycyrrhizae dengan eksipien komersil secara pemampatan terus
title_fullStr	Perbandingan sifat-sifat pentabletan Radix Glycyrrhizae dengan eksipien komersil secara pemampatan terus
title_full_unstemmed	Perbandingan sifat-sifat pentabletan Radix Glycyrrhizae dengan eksipien komersil secara pemampatan terus
title_sort	perbandingan sifat-sifat pentabletan radix glycyrrhizae dengan eksipien komersil secara pemampatan terus
publisher	penerbit ukm
publishDate	2005
url	http://journalarticle.ukm.my/988/ http://journalarticle.ukm.my/988/ http://journalarticle.ukm.my/988/1/jurnal41.pdf
first_indexed	2023-09-18T19:32:04Z
last_indexed	2023-09-18T19:32:04Z
_version_	1777405027492560896

Perbandingan sifat-sifat pentabletan Radix Glycyrrhizae dengan eksipien komersil secara pemampatan terus

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