Detection of gliclazide in aqueous samples using liquid chromatography/time-of-flight/mass spectrometry

The big challenge for the detection of pharmaceutical residues in water samples is the type of ionization mode in terms of positive or negative ionization which plays an important role to identify and quantify the analytes using liquid chromatography/mass spectrometry. An analytical method was appli...

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Main Authors:	Al-Qaim, Fouad Fadhil, Md Pauzi Abdullah, Jalifah Latip, Wan Mohd Afiq Wan Mohd Khalik, Nurfaizah Abu Tahrim, Nurul Auni Zainal Abidin, Mohamed Rozali Othman
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2016
Online Access:	http://journalarticle.ukm.my/9885/ http://journalarticle.ukm.my/9885/ http://journalarticle.ukm.my/9885/1/17_Fouad_Fadhil.pdf

id	ukm-9885
recordtype	eprints
spelling	ukm-98852016-12-14T06:51:09Z http://journalarticle.ukm.my/9885/ Detection of gliclazide in aqueous samples using liquid chromatography/time-of-flight/mass spectrometry Al-Qaim, Fouad Fadhil Md Pauzi Abdullah, Jalifah Latip, Wan Mohd Afiq Wan Mohd Khalik, Nurfaizah Abu Tahrim, Nurul Auni Zainal Abidin, Mohamed Rozali Othman, The big challenge for the detection of pharmaceutical residues in water samples is the type of ionization mode in terms of positive or negative ionization which plays an important role to identify and quantify the analytes using liquid chromatography/mass spectrometry. An analytical method was applied to analysis of gliclazide (diabetic drug) in surface water and wastewater from sewage treatment plants and hospitals. The proposed analytical method allows simultaneous isolation and concentration procedure using solid phase extraction (Oasis HLB) prior to separation using high-performance liquid chromatography. The detection and confirmation was achieved by applying time-of-flight analyzer. The limits of quantification were as low as 1.4 ng/L (deionized water), 4 ng/L (surface water), 27 ng/L (hospital influent), 10 ng/L (hospital effluent), 6 ng/L (sewage treatment plant effluent) and 21 ng/L (sewage treatment plant influent), respectively. On average, good recoveries of higher than 87% were obtained for gliclazide in the studied samples. The proposed method successfully determined and quantified gliclazide in surface water and wastewater. The results showed that gliclazide is a persistent compound in sewage treatment effluents as well as in the recipient rivers. Gliclazide was detected in all samples and the highest concentration was 130 ng/L in influent of sewage treatment plant. Penerbit Universiti Kebangsaan Malaysia 2016-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9885/1/17_Fouad_Fadhil.pdf Al-Qaim, Fouad Fadhil and Md Pauzi Abdullah, and Jalifah Latip, and Wan Mohd Afiq Wan Mohd Khalik, and Nurfaizah Abu Tahrim, and Nurul Auni Zainal Abidin, and Mohamed Rozali Othman, (2016) Detection of gliclazide in aqueous samples using liquid chromatography/time-of-flight/mass spectrometry. Sains Malaysiana, 45 (5). pp. 803-810. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol45num5_2016/contentsVol45num5_2016.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The big challenge for the detection of pharmaceutical residues in water samples is the type of ionization mode in terms of positive or negative ionization which plays an important role to identify and quantify the analytes using liquid chromatography/mass spectrometry. An analytical method was applied to analysis of gliclazide (diabetic drug) in surface water and wastewater from sewage treatment plants and hospitals. The proposed analytical method allows simultaneous isolation and concentration procedure using solid phase extraction (Oasis HLB) prior to separation using high-performance liquid chromatography. The detection and confirmation was achieved by applying time-of-flight analyzer. The limits of quantification were as low as 1.4 ng/L (deionized water), 4 ng/L (surface water), 27 ng/L (hospital influent), 10 ng/L (hospital effluent), 6 ng/L (sewage treatment plant effluent) and 21 ng/L (sewage treatment plant influent), respectively. On average, good recoveries of higher than 87% were obtained for gliclazide in the studied samples. The proposed method successfully determined and quantified gliclazide in surface water and wastewater. The results showed that gliclazide is a persistent compound in sewage treatment effluents as well as in the recipient rivers. Gliclazide was detected in all samples and the highest concentration was 130 ng/L in influent of sewage treatment plant.
format	Article
author	Al-Qaim, Fouad Fadhil Md Pauzi Abdullah, Jalifah Latip, Wan Mohd Afiq Wan Mohd Khalik, Nurfaizah Abu Tahrim, Nurul Auni Zainal Abidin, Mohamed Rozali Othman,
spellingShingle	Al-Qaim, Fouad Fadhil Md Pauzi Abdullah, Jalifah Latip, Wan Mohd Afiq Wan Mohd Khalik, Nurfaizah Abu Tahrim, Nurul Auni Zainal Abidin, Mohamed Rozali Othman, Detection of gliclazide in aqueous samples using liquid chromatography/time-of-flight/mass spectrometry
author_facet	Al-Qaim, Fouad Fadhil Md Pauzi Abdullah, Jalifah Latip, Wan Mohd Afiq Wan Mohd Khalik, Nurfaizah Abu Tahrim, Nurul Auni Zainal Abidin, Mohamed Rozali Othman,
author_sort	Al-Qaim, Fouad Fadhil
title	Detection of gliclazide in aqueous samples using liquid chromatography/time-of-flight/mass spectrometry
title_short	Detection of gliclazide in aqueous samples using liquid chromatography/time-of-flight/mass spectrometry
title_full	Detection of gliclazide in aqueous samples using liquid chromatography/time-of-flight/mass spectrometry
title_fullStr	Detection of gliclazide in aqueous samples using liquid chromatography/time-of-flight/mass spectrometry
title_full_unstemmed	Detection of gliclazide in aqueous samples using liquid chromatography/time-of-flight/mass spectrometry
title_sort	detection of gliclazide in aqueous samples using liquid chromatography/time-of-flight/mass spectrometry
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2016
url	http://journalarticle.ukm.my/9885/ http://journalarticle.ukm.my/9885/ http://journalarticle.ukm.my/9885/1/17_Fouad_Fadhil.pdf
first_indexed	2023-09-18T19:56:00Z
last_indexed	2023-09-18T19:56:00Z
_version_	1777406532689854464

Detection of gliclazide in aqueous samples using liquid chromatography/time-of-flight/mass spectrometry

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