Formulation of wound healing hydrogel based on keratin derived from chicken feather

A novel cross-linked keratin hydrogel dressing was developed by incorporating keratin from chicken feather into hydrogel dressing formulation. Keratin fibers from feathers are non-abrasive, eco-friendly, biodegradable, insoluble in organic solvents and also have good mechanical properties, low dens...

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Main Author:	Priyaah, Kumaran
Format:	Undergraduates Project Papers
Language:	English
Published:	2014
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/12469/ http://umpir.ump.edu.my/id/eprint/12469/ http://umpir.ump.edu.my/id/eprint/12469/1/FKKSA%20-%20PRIYAAH%20KUMARAN.PDF

id	ump-12469
recordtype	eprints
spelling	ump-124692016-03-28T07:05:12Z http://umpir.ump.edu.my/id/eprint/12469/ Formulation of wound healing hydrogel based on keratin derived from chicken feather Priyaah, Kumaran TP Chemical technology A novel cross-linked keratin hydrogel dressing was developed by incorporating keratin from chicken feather into hydrogel dressing formulation. Keratin fibers from feathers are non-abrasive, eco-friendly, biodegradable, insoluble in organic solvents and also have good mechanical properties, low density, hydrophobic behaviour and finally low cost. In the matter of fact, keratinocytes (epidermal cells that manufacture and contain keratin) migrate from wound edges to cover the wound during healing process. These characteristics open a new approach to do research on keratin based hydrogel which derived from chicken feather for wound care product. In this study, the physical properties of keratin based hydrogel and its wound healing efficacy on small wounds in rabbits were assessed. Keratin based hydrogels have been done for five types of formulation. Optimum concentration of keratin has been identified from previous studies. Some of analysis of keratin based hydrogel includes spectroscopic analysis using Fourier transform infrared and Raman, microbial count analysis and heavy metal test using Inductively Coupled Plasma Mass Spectrometer (ICP-MS). XRD analysis was performed to analyse the crystallinity index of the hydrogel which lied between 30-50% of crystallinity. Morphological details are observed with optical, transmission and scanning electron microscopy. Swelling and solubility tests are carried out on the hydrogel to observe the solid content and water absorbance capacity of the hydrogel. Application of keratin hydrogel dressings significantly enhanced (P < 0.05) wound closure and accelerated the rate of re-epithelialization as compared to control hydrogel and other film dressing. Overall, this product is safe to use and acted as an effective wound healing product with appropriate hydrogel characteristics. Thus, the studies reviewed can be the scaffolding to increase the use of this protein for wound care product as the keratin from chicken feathers are shown as a novel eco-friendly material which is very beneficial and profitable. 2014-12 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/12469/1/FKKSA%20-%20PRIYAAH%20KUMARAN.PDF Priyaah, Kumaran (2014) Formulation of wound healing hydrogel based on keratin derived from chicken feather. Faculty of Chemical & Natural Resources Engineering, Universiti Malaysia Pahang. http://iportal.ump.edu.my/lib/item?id=chamo:91370&theme=UMP2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Priyaah, Kumaran Formulation of wound healing hydrogel based on keratin derived from chicken feather
description	A novel cross-linked keratin hydrogel dressing was developed by incorporating keratin from chicken feather into hydrogel dressing formulation. Keratin fibers from feathers are non-abrasive, eco-friendly, biodegradable, insoluble in organic solvents and also have good mechanical properties, low density, hydrophobic behaviour and finally low cost. In the matter of fact, keratinocytes (epidermal cells that manufacture and contain keratin) migrate from wound edges to cover the wound during healing process. These characteristics open a new approach to do research on keratin based hydrogel which derived from chicken feather for wound care product. In this study, the physical properties of keratin based hydrogel and its wound healing efficacy on small wounds in rabbits were assessed. Keratin based hydrogels have been done for five types of formulation. Optimum concentration of keratin has been identified from previous studies. Some of analysis of keratin based hydrogel includes spectroscopic analysis using Fourier transform infrared and Raman, microbial count analysis and heavy metal test using Inductively Coupled Plasma Mass Spectrometer (ICP-MS). XRD analysis was performed to analyse the crystallinity index of the hydrogel which lied between 30-50% of crystallinity. Morphological details are observed with optical, transmission and scanning electron microscopy. Swelling and solubility tests are carried out on the hydrogel to observe the solid content and water absorbance capacity of the hydrogel. Application of keratin hydrogel dressings significantly enhanced (P < 0.05) wound closure and accelerated the rate of re-epithelialization as compared to control hydrogel and other film dressing. Overall, this product is safe to use and acted as an effective wound healing product with appropriate hydrogel characteristics. Thus, the studies reviewed can be the scaffolding to increase the use of this protein for wound care product as the keratin from chicken feathers are shown as a novel eco-friendly material which is very beneficial and profitable.
format	Undergraduates Project Papers
author	Priyaah, Kumaran
author_facet	Priyaah, Kumaran
author_sort	Priyaah, Kumaran
title	Formulation of wound healing hydrogel based on keratin derived from chicken feather
title_short	Formulation of wound healing hydrogel based on keratin derived from chicken feather
title_full	Formulation of wound healing hydrogel based on keratin derived from chicken feather
title_fullStr	Formulation of wound healing hydrogel based on keratin derived from chicken feather
title_full_unstemmed	Formulation of wound healing hydrogel based on keratin derived from chicken feather
title_sort	formulation of wound healing hydrogel based on keratin derived from chicken feather
publishDate	2014
url	http://umpir.ump.edu.my/id/eprint/12469/ http://umpir.ump.edu.my/id/eprint/12469/ http://umpir.ump.edu.my/id/eprint/12469/1/FKKSA%20-%20PRIYAAH%20KUMARAN.PDF
first_indexed	2023-09-18T22:14:09Z
last_indexed	2023-09-18T22:14:09Z
_version_	1777415225231802368

Formulation of wound healing hydrogel based on keratin derived from chicken feather

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