Transformation of carbamazepine dihydrate to anhydrous carbamazepine

An investigation of carbamazepine dihydrate transformation to anhydrous carbamazepine was presented. In this works, carbamazepine dihydrate and solvents (ethanol, methanol, propanol, acetonitrile, ethyl acetate and methyl acetate) were used. The crystallization process was conducted using different...

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Main Author:	Noraini, Ghazali
Format:	Undergraduates Project Papers
Language:	English English English
Published:	2015
Subjects:	Q Science (General) TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/12855/ http://umpir.ump.edu.my/id/eprint/12855/ http://umpir.ump.edu.my/id/eprint/12855/1/FKKSA%20-%20NORAINI%20GHAZALI%20-%20CD%209570.pdf http://umpir.ump.edu.my/id/eprint/12855/2/FKKSA%20-%20NORAINI%20GHAZALI%20-%20CD%209570%20-%20CHAP%201.pdf http://umpir.ump.edu.my/id/eprint/12855/3/FKKSA%20-%20NORAINI%20GHAZALI%20-%20CD%209570%20-%20CHAP%203.pdf

id	ump-12855
recordtype	eprints
spelling	ump-128552016-04-14T01:20:21Z http://umpir.ump.edu.my/id/eprint/12855/ Transformation of carbamazepine dihydrate to anhydrous carbamazepine Noraini, Ghazali Q Science (General) TP Chemical technology An investigation of carbamazepine dihydrate transformation to anhydrous carbamazepine was presented. In this works, carbamazepine dihydrate and solvents (ethanol, methanol, propanol, acetonitrile, ethyl acetate and methyl acetate) were used. The crystallization process was conducted using different solvents by applying solid state method using differential scanning calorimetry analysis and solution based method. For solution based method, three conditions of the experiment were implemented i.e. dissolution with heating and cooling without stirring, dissolution with heating and cooling with stirring, dissolution with heating and stirring followed by cooling without stirring. Solid state characterization of the crystals were analysed using Differential Scanning Calorimetry (DSC) and Powder X-Ray Diffraction (PXRD). Analysis data obtained from DSC revealed that the crystals produced from the transformation of carbamazepine dihydrate to anhydrous carbamazepine using solid state and solution based method were not successful. From DSC analysis, the melting point of carbamazepine dihydrate with six solvents for both methods were in the range of 70-160oC. The finding from DSC analysis showed that the melting point of crystals did not fall within the melting point value of the anhydrous form. Referring to the PXRD analysis, the pattern profile of carbamazepine in six solvents with three different conditions does not similar to the literature for the indicative peaks of anhydrous form. It was suggested that the crystals obtained from the dissolution of carbamazepine dihydrate with six solvents using three different conditions were unsuccessful to transform carbamazepine dihydrate to anhydrous carbamazepine. Further study using different techniques and conditions were suggested in order to study the transformation of carbamazepine dihydrate to anhydrous carbamazepine. 2015-06 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/12855/1/FKKSA%20-%20NORAINI%20GHAZALI%20-%20CD%209570.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/12855/2/FKKSA%20-%20NORAINI%20GHAZALI%20-%20CD%209570%20-%20CHAP%201.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/12855/3/FKKSA%20-%20NORAINI%20GHAZALI%20-%20CD%209570%20-%20CHAP%203.pdf Noraini, Ghazali (2015) Transformation of carbamazepine dihydrate to anhydrous carbamazepine. Faculty of Chemical & Natural Resources Engineering, Universiti Malaysia Pahang. http://iportal.ump.edu.my/lib/item?id=chamo:93797&theme=UMP2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English English English
topic	Q Science (General) TP Chemical technology
spellingShingle	Q Science (General) TP Chemical technology Noraini, Ghazali Transformation of carbamazepine dihydrate to anhydrous carbamazepine
description	An investigation of carbamazepine dihydrate transformation to anhydrous carbamazepine was presented. In this works, carbamazepine dihydrate and solvents (ethanol, methanol, propanol, acetonitrile, ethyl acetate and methyl acetate) were used. The crystallization process was conducted using different solvents by applying solid state method using differential scanning calorimetry analysis and solution based method. For solution based method, three conditions of the experiment were implemented i.e. dissolution with heating and cooling without stirring, dissolution with heating and cooling with stirring, dissolution with heating and stirring followed by cooling without stirring. Solid state characterization of the crystals were analysed using Differential Scanning Calorimetry (DSC) and Powder X-Ray Diffraction (PXRD). Analysis data obtained from DSC revealed that the crystals produced from the transformation of carbamazepine dihydrate to anhydrous carbamazepine using solid state and solution based method were not successful. From DSC analysis, the melting point of carbamazepine dihydrate with six solvents for both methods were in the range of 70-160oC. The finding from DSC analysis showed that the melting point of crystals did not fall within the melting point value of the anhydrous form. Referring to the PXRD analysis, the pattern profile of carbamazepine in six solvents with three different conditions does not similar to the literature for the indicative peaks of anhydrous form. It was suggested that the crystals obtained from the dissolution of carbamazepine dihydrate with six solvents using three different conditions were unsuccessful to transform carbamazepine dihydrate to anhydrous carbamazepine. Further study using different techniques and conditions were suggested in order to study the transformation of carbamazepine dihydrate to anhydrous carbamazepine.
format	Undergraduates Project Papers
author	Noraini, Ghazali
author_facet	Noraini, Ghazali
author_sort	Noraini, Ghazali
title	Transformation of carbamazepine dihydrate to anhydrous carbamazepine
title_short	Transformation of carbamazepine dihydrate to anhydrous carbamazepine
title_full	Transformation of carbamazepine dihydrate to anhydrous carbamazepine
title_fullStr	Transformation of carbamazepine dihydrate to anhydrous carbamazepine
title_full_unstemmed	Transformation of carbamazepine dihydrate to anhydrous carbamazepine
title_sort	transformation of carbamazepine dihydrate to anhydrous carbamazepine
publishDate	2015
url	http://umpir.ump.edu.my/id/eprint/12855/ http://umpir.ump.edu.my/id/eprint/12855/ http://umpir.ump.edu.my/id/eprint/12855/1/FKKSA%20-%20NORAINI%20GHAZALI%20-%20CD%209570.pdf http://umpir.ump.edu.my/id/eprint/12855/2/FKKSA%20-%20NORAINI%20GHAZALI%20-%20CD%209570%20-%20CHAP%201.pdf http://umpir.ump.edu.my/id/eprint/12855/3/FKKSA%20-%20NORAINI%20GHAZALI%20-%20CD%209570%20-%20CHAP%203.pdf
first_indexed	2023-09-18T22:14:50Z
last_indexed	2023-09-18T22:14:50Z
_version_	1777415267390849024

Transformation of carbamazepine dihydrate to anhydrous carbamazepine

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