Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method

Co-crystal plays a critical role in the pharmaceutical industry and becoming as an alternative approach to improve the bioavailability of poor water soluble drugs especially for a weakly ionisable groups or neutral compounds. In this study the co-crystal screening was carried out for carbamazepine (...

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Main Authors:	Fatinah, Ab Rahman, Syarifah, Abd Rahim, Tan, Chou C., Han, L. S., Noor Ashila, Ramle
Format:	Article
Language:	English
Published:	IACSIT Press 2017
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/13162/ http://umpir.ump.edu.my/id/eprint/13162/ http://umpir.ump.edu.my/id/eprint/13162/ http://umpir.ump.edu.my/id/eprint/13162/1/Carbamazepine-Fumaric%20Acid%20and%20Carbamazepine-Succinic%20Acid%20Co-crystal%20Screening%20Using%20Solution%20Based%20Method.pdf

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spelling	ump-131622019-10-30T07:38:11Z http://umpir.ump.edu.my/id/eprint/13162/ Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method Fatinah, Ab Rahman Syarifah, Abd Rahim Tan, Chou C. Han, L. S. Noor Ashila, Ramle TP Chemical technology Co-crystal plays a critical role in the pharmaceutical industry and becoming as an alternative approach to improve the bioavailability of poor water soluble drugs especially for a weakly ionisable groups or neutral compounds. In this study the co-crystal screening was carried out for carbamazepine (CBZ) and co-crystal former (CCF) of fumaric acid (FUM) and succinic acid (SA) using non-stoichiometric method (addition of CBZ to CCF saturated solution) and stoichiometric method (evaporation of 1:1 molar ratio of CBZ to CCF) in acetonitrile, ethyl acetate, propanol, ethanol and formic acid solvent systems. The crystals produced from the screening were characterized using Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FT-IR). The PXRD analysis had confirmed that the co-crystal was successfully formed in both methods for all of the solvent system studied with an exception to formic acid in the stoichiometric method for CBZ-FUM system and in all methods for CBZ-SA system. The findings from this analysis revealed that Form A and Form B of CBZ-FUM co-crystal had been successfully formed from different solvents systems. DSC analysis had shown that the melting point of CBZ-FUM and CBZ-SA co-crystals were in the range similar to the previous study. The characterization using FT-IR indicated that the functional groups which include amides and carboxylic acids were presented in the co-crystal produced. Further study on the co-crystal solubility and dissolution rate is needed in order to access the efficacy of the co-crystal since the screening methods have been successfully confirmed the formation of the co-crystal. IACSIT Press 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/13162/1/Carbamazepine-Fumaric%20Acid%20and%20Carbamazepine-Succinic%20Acid%20Co-crystal%20Screening%20Using%20Solution%20Based%20Method.pdf Fatinah, Ab Rahman and Syarifah, Abd Rahim and Tan, Chou C. and Han, L. S. and Noor Ashila, Ramle (2017) Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method. International Journal of Chemical Engineering and Applications (IJCEA), 8 (2). pp. 136-140. ISSN 2010-0221 http://www.ijcea.org/index.php?m=content&c=index&a=show&catid=86&id=1023 DOI: 10.18178/ijcea.2017.8.2.645
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Fatinah, Ab Rahman Syarifah, Abd Rahim Tan, Chou C. Han, L. S. Noor Ashila, Ramle Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method
description	Co-crystal plays a critical role in the pharmaceutical industry and becoming as an alternative approach to improve the bioavailability of poor water soluble drugs especially for a weakly ionisable groups or neutral compounds. In this study the co-crystal screening was carried out for carbamazepine (CBZ) and co-crystal former (CCF) of fumaric acid (FUM) and succinic acid (SA) using non-stoichiometric method (addition of CBZ to CCF saturated solution) and stoichiometric method (evaporation of 1:1 molar ratio of CBZ to CCF) in acetonitrile, ethyl acetate, propanol, ethanol and formic acid solvent systems. The crystals produced from the screening were characterized using Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FT-IR). The PXRD analysis had confirmed that the co-crystal was successfully formed in both methods for all of the solvent system studied with an exception to formic acid in the stoichiometric method for CBZ-FUM system and in all methods for CBZ-SA system. The findings from this analysis revealed that Form A and Form B of CBZ-FUM co-crystal had been successfully formed from different solvents systems. DSC analysis had shown that the melting point of CBZ-FUM and CBZ-SA co-crystals were in the range similar to the previous study. The characterization using FT-IR indicated that the functional groups which include amides and carboxylic acids were presented in the co-crystal produced. Further study on the co-crystal solubility and dissolution rate is needed in order to access the efficacy of the co-crystal since the screening methods have been successfully confirmed the formation of the co-crystal.
format	Article
author	Fatinah, Ab Rahman Syarifah, Abd Rahim Tan, Chou C. Han, L. S. Noor Ashila, Ramle
author_facet	Fatinah, Ab Rahman Syarifah, Abd Rahim Tan, Chou C. Han, L. S. Noor Ashila, Ramle
author_sort	Fatinah, Ab Rahman
title	Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method
title_short	Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method
title_full	Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method
title_fullStr	Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method
title_full_unstemmed	Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method
title_sort	carbamazepine-fumaric acid and carbamazepine-succinic acid co-crystal screening using solution based method
publisher	IACSIT Press
publishDate	2017
url	http://umpir.ump.edu.my/id/eprint/13162/ http://umpir.ump.edu.my/id/eprint/13162/ http://umpir.ump.edu.my/id/eprint/13162/ http://umpir.ump.edu.my/id/eprint/13162/1/Carbamazepine-Fumaric%20Acid%20and%20Carbamazepine-Succinic%20Acid%20Co-crystal%20Screening%20Using%20Solution%20Based%20Method.pdf
first_indexed	2023-09-18T22:15:27Z
last_indexed	2023-09-18T22:15:27Z
_version_	1777415306665263104

Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method

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