Carbamazepine-Fumaric Acid Co-Crystal Screening Using Solution Based Method

Co-crystals is a multi-component system which connected by non-covalent interactions, present physically as a solid form under ambient conditions. Nowadays, co-crystal has becoming as an alternative approach to improve the bioavailability of poor water soluble drugs especially for a weakly ionisable...

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Main Authors:	Syarifah, Abd Rahim, Chou, C. Tan, Noor Ashila, Ramle
Format:	Article
Language:	English
Published:	EDP Sciences, 2015 2016
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/14072/ http://umpir.ump.edu.my/id/eprint/14072/ http://umpir.ump.edu.my/id/eprint/14072/ http://umpir.ump.edu.my/id/eprint/14072/1/Carbamazepine-Fumaric%20Acid%20Co-Crystal%20Screening%20Using%20Solution%20Based%20Method.pdf

id	ump-14072
recordtype	eprints
spelling	ump-140722016-12-28T07:29:18Z http://umpir.ump.edu.my/id/eprint/14072/ Carbamazepine-Fumaric Acid Co-Crystal Screening Using Solution Based Method Syarifah, Abd Rahim Chou, C. Tan Noor Ashila, Ramle TP Chemical technology Co-crystals is a multi-component system which connected by non-covalent interactions, present physically as a solid form under ambient conditions. Nowadays, co-crystal has becoming as an alternative approach to improve the bioavailability of poor water soluble drugs especially for a weakly ionisable groups or neutral compounds. In this study the co-crystal screening was carried out for carbamazepine (CBZ) and fumaric acid (FUM) co-crystal former (CCF) using non-stoichiometric method (addition of CBZ to CCF saturated solution) and stoichiometric method (evaporation of 1:1 molar ratio of CBZ to CCF) in acetonitrile, ethyl acetate, propanol, ethanol and formic acid solvent systems. The crystals produced from the screening were characterized using Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FT-IR). The PXRD analysis had confirmed that the co-crystal was successfully formed in both methods for all of the solvent system studied with an exception to formic acid in the stoichiometric method where no crystal was found precipitate. The findings from this study revealed that Form A and Form B of CBZ-FUM co-crystal had been successfully formed from different solvent systems. EDP Sciences, 2015 2016 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/14072/1/Carbamazepine-Fumaric%20Acid%20Co-Crystal%20Screening%20Using%20Solution%20Based%20Method.pdf Syarifah, Abd Rahim and Chou, C. Tan and Noor Ashila, Ramle (2016) Carbamazepine-Fumaric Acid Co-Crystal Screening Using Solution Based Method. MATEC Web of Conferences, 69. pp. 1-5. ISSN 2261-236X http://dx.doi.org/10.1051/matecconf/20166903003 dx.doi.org/10.1051/matecconf/20166903003
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Syarifah, Abd Rahim Chou, C. Tan Noor Ashila, Ramle Carbamazepine-Fumaric Acid Co-Crystal Screening Using Solution Based Method
description	Co-crystals is a multi-component system which connected by non-covalent interactions, present physically as a solid form under ambient conditions. Nowadays, co-crystal has becoming as an alternative approach to improve the bioavailability of poor water soluble drugs especially for a weakly ionisable groups or neutral compounds. In this study the co-crystal screening was carried out for carbamazepine (CBZ) and fumaric acid (FUM) co-crystal former (CCF) using non-stoichiometric method (addition of CBZ to CCF saturated solution) and stoichiometric method (evaporation of 1:1 molar ratio of CBZ to CCF) in acetonitrile, ethyl acetate, propanol, ethanol and formic acid solvent systems. The crystals produced from the screening were characterized using Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FT-IR). The PXRD analysis had confirmed that the co-crystal was successfully formed in both methods for all of the solvent system studied with an exception to formic acid in the stoichiometric method where no crystal was found precipitate. The findings from this study revealed that Form A and Form B of CBZ-FUM co-crystal had been successfully formed from different solvent systems.
format	Article
author	Syarifah, Abd Rahim Chou, C. Tan Noor Ashila, Ramle
author_facet	Syarifah, Abd Rahim Chou, C. Tan Noor Ashila, Ramle
author_sort	Syarifah, Abd Rahim
title	Carbamazepine-Fumaric Acid Co-Crystal Screening Using Solution Based Method
title_short	Carbamazepine-Fumaric Acid Co-Crystal Screening Using Solution Based Method
title_full	Carbamazepine-Fumaric Acid Co-Crystal Screening Using Solution Based Method
title_fullStr	Carbamazepine-Fumaric Acid Co-Crystal Screening Using Solution Based Method
title_full_unstemmed	Carbamazepine-Fumaric Acid Co-Crystal Screening Using Solution Based Method
title_sort	carbamazepine-fumaric acid co-crystal screening using solution based method
publisher	EDP Sciences, 2015
publishDate	2016
url	http://umpir.ump.edu.my/id/eprint/14072/ http://umpir.ump.edu.my/id/eprint/14072/ http://umpir.ump.edu.my/id/eprint/14072/ http://umpir.ump.edu.my/id/eprint/14072/1/Carbamazepine-Fumaric%20Acid%20Co-Crystal%20Screening%20Using%20Solution%20Based%20Method.pdf
first_indexed	2023-09-18T22:17:24Z
last_indexed	2023-09-18T22:17:24Z
_version_	1777415429626527744

Carbamazepine-Fumaric Acid Co-Crystal Screening Using Solution Based Method

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