Ibuprofen-Amino Acids Co-Crystal Screening Via Co-Grinding Methods

The importance of pharmaceutical co-crystals now has been recognized in order to improve the research and development in pharmaceutical industries. Low solubility of active pharmaceutical ingredient (API) has led to the growth of new pharmaceutical co-crystals formation as it enhances the physicoche...

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Main Authors:	Muhamad Fitri, Othman, Norasikin, Jamburi, Nornizar, Anuar, Syarifah, Abd Rahim, Nurul Hazwani, Rohalim
Format:	Conference or Workshop Item
Language:	English
Published:	EDP Sciences 2016
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/14619/ http://umpir.ump.edu.my/id/eprint/14619/ http://umpir.ump.edu.my/id/eprint/14619/1/Ibuprofen-Amino%20Acids%20Co-Crystal%20Screening%20Via%20Co-Grinding%20Methods.pdf

id	ump-14619
recordtype	eprints
spelling	ump-146192017-04-05T07:20:58Z http://umpir.ump.edu.my/id/eprint/14619/ Ibuprofen-Amino Acids Co-Crystal Screening Via Co-Grinding Methods Muhamad Fitri, Othman Norasikin, Jamburi Nornizar, Anuar Syarifah, Abd Rahim Nurul Hazwani, Rohalim TP Chemical technology The importance of pharmaceutical co-crystals now has been recognized in order to improve the research and development in pharmaceutical industries. Low solubility of active pharmaceutical ingredient (API) has led to the growth of new pharmaceutical co-crystals formation as it enhances the physicochemical properties of the API. In this works, preparation of new co-crystal formation between ibuprofen (IBP) with selected amino acid compounds were performed by using dry grinding and liquid assisted grinding (LAG) techniques. Ibuprofen (IBP) was selected as the API meanwhile glycine (GLY), L-alanine (ALA) and L-proline (PRO) were selected as co-crystal former (CCF) agents. The products of IBP-co-former from grinding experiments for the formation of co-crystals were characterized and verified using X-Ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infra-Red Spectroscopy (FTIR). The finding reveals that the IBP-PRO co-crystals have successfully formed. For IBP-PRO system, new crystalline peaks from XRPD were recorded at 2θ values of 4.374°, 5.436° and 10.944° from dry grinding technique and 4.41°, 5.436° and 10.962° for liquid assisted grinding (LAG) technique. A new melting point of 257.49 °C was discovered for IBP-ALA indicates the possibility of co-crystals formation. On the other hand, the analysis for IBP-GLY shows that no co-crystals formed in the system. EDP Sciences 2016 Conference or Workshop Item PeerReviewed application/pdf en cc_by http://umpir.ump.edu.my/id/eprint/14619/1/Ibuprofen-Amino%20Acids%20Co-Crystal%20Screening%20Via%20Co-Grinding%20Methods.pdf Muhamad Fitri, Othman and Norasikin, Jamburi and Nornizar, Anuar and Syarifah, Abd Rahim and Nurul Hazwani, Rohalim (2016) Ibuprofen-Amino Acids Co-Crystal Screening Via Co-Grinding Methods. In: MATEC Web of Conferences: 5th International Conference on Chemical and Process Engineering (ICCPE 2016), 23-25 May 2016 , Jeju Island, South Korea. pp. 1-6., 69 (03002). ISSN 2261-236X https://doi.org/10.1051/matecconf/20166903002
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Muhamad Fitri, Othman Norasikin, Jamburi Nornizar, Anuar Syarifah, Abd Rahim Nurul Hazwani, Rohalim Ibuprofen-Amino Acids Co-Crystal Screening Via Co-Grinding Methods
description	The importance of pharmaceutical co-crystals now has been recognized in order to improve the research and development in pharmaceutical industries. Low solubility of active pharmaceutical ingredient (API) has led to the growth of new pharmaceutical co-crystals formation as it enhances the physicochemical properties of the API. In this works, preparation of new co-crystal formation between ibuprofen (IBP) with selected amino acid compounds were performed by using dry grinding and liquid assisted grinding (LAG) techniques. Ibuprofen (IBP) was selected as the API meanwhile glycine (GLY), L-alanine (ALA) and L-proline (PRO) were selected as co-crystal former (CCF) agents. The products of IBP-co-former from grinding experiments for the formation of co-crystals were characterized and verified using X-Ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infra-Red Spectroscopy (FTIR). The finding reveals that the IBP-PRO co-crystals have successfully formed. For IBP-PRO system, new crystalline peaks from XRPD were recorded at 2θ values of 4.374°, 5.436° and 10.944° from dry grinding technique and 4.41°, 5.436° and 10.962° for liquid assisted grinding (LAG) technique. A new melting point of 257.49 °C was discovered for IBP-ALA indicates the possibility of co-crystals formation. On the other hand, the analysis for IBP-GLY shows that no co-crystals formed in the system.
format	Conference or Workshop Item
author	Muhamad Fitri, Othman Norasikin, Jamburi Nornizar, Anuar Syarifah, Abd Rahim Nurul Hazwani, Rohalim
author_facet	Muhamad Fitri, Othman Norasikin, Jamburi Nornizar, Anuar Syarifah, Abd Rahim Nurul Hazwani, Rohalim
author_sort	Muhamad Fitri, Othman
title	Ibuprofen-Amino Acids Co-Crystal Screening Via Co-Grinding Methods
title_short	Ibuprofen-Amino Acids Co-Crystal Screening Via Co-Grinding Methods
title_full	Ibuprofen-Amino Acids Co-Crystal Screening Via Co-Grinding Methods
title_fullStr	Ibuprofen-Amino Acids Co-Crystal Screening Via Co-Grinding Methods
title_full_unstemmed	Ibuprofen-Amino Acids Co-Crystal Screening Via Co-Grinding Methods
title_sort	ibuprofen-amino acids co-crystal screening via co-grinding methods
publisher	EDP Sciences
publishDate	2016
url	http://umpir.ump.edu.my/id/eprint/14619/ http://umpir.ump.edu.my/id/eprint/14619/ http://umpir.ump.edu.my/id/eprint/14619/1/Ibuprofen-Amino%20Acids%20Co-Crystal%20Screening%20Via%20Co-Grinding%20Methods.pdf
first_indexed	2023-09-18T22:18:35Z
last_indexed	2023-09-18T22:18:35Z
_version_	1777415503475638272

Ibuprofen-Amino Acids Co-Crystal Screening Via Co-Grinding Methods

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