Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles
In this work, polymeric nanoparticles containing Pregabalin was prepared and optimized the ideal concentration of polymer based on its in vitro release profile for a period of 24hrs.The nanoparticles were prepared by solvent displacement method using various concentrations of Eudragit S100 (EPNP1-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Malaysia Pahang
2016
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/16156/ http://umpir.ump.edu.my/id/eprint/16156/ http://umpir.ump.edu.my/id/eprint/16156/ http://umpir.ump.edu.my/id/eprint/16156/1/ftek-2016-9.pdf |
| Summary: | In this work, polymeric nanoparticles containing Pregabalin was prepared and optimized the ideal
concentration of polymer based on its in vitro release profile for a period of 24hrs.The nanoparticles were
prepared by solvent displacement method using various concentrations of Eudragit S100 (EPNP1-EPNP5).
The prepared nanoparticles were characterized for its particle size, zeta potential, drug content, entrapment
efficiency and invitro drug release profile. The preformulation study results confirmed the compatibility
between the drug and other excipients used in the formulation. The optimized formulation was selected based
on its particle size, entrapment efficiency and in vitro drug release profile. The formulation which contains
300mg of Eudragit S100 (EPNP5) was selected as optimized concentration for the controlled release of
Pregabalin for a period of 24hrs. |
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