Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles

Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles

In this work, polymeric nanoparticles containing Pregabalin was prepared and optimized the ideal concentration of polymer based on its in vitro release profile for a period of 24hrs.The nanoparticles were prepared by solvent displacement method using various concentrations of Eudragit S100 (EPNP1-...

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Main Authors: Senthilnathan, B., Maheswaran, A., Gopalasatheeskumar, K., Masilamani, K., Raihana Z., Edros
Format: Article
Language:English
Published: Penerbit Universiti Malaysia Pahang 2016
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/16156/
http://umpir.ump.edu.my/id/eprint/16156/
http://umpir.ump.edu.my/id/eprint/16156/
http://umpir.ump.edu.my/id/eprint/16156/1/ftek-2016-9.pdf
id ump-16156
recordtype eprints
spelling ump-161562018-02-01T06:04:57Z http://umpir.ump.edu.my/id/eprint/16156/ Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles Senthilnathan, B. Maheswaran, A. Gopalasatheeskumar, K. Masilamani, K. Raihana Z., Edros TP Chemical technology In this work, polymeric nanoparticles containing Pregabalin was prepared and optimized the ideal concentration of polymer based on its in vitro release profile for a period of 24hrs.The nanoparticles were prepared by solvent displacement method using various concentrations of Eudragit S100 (EPNP1-EPNP5). The prepared nanoparticles were characterized for its particle size, zeta potential, drug content, entrapment efficiency and invitro drug release profile. The preformulation study results confirmed the compatibility between the drug and other excipients used in the formulation. The optimized formulation was selected based on its particle size, entrapment efficiency and in vitro drug release profile. The formulation which contains 300mg of Eudragit S100 (EPNP5) was selected as optimized concentration for the controlled release of Pregabalin for a period of 24hrs. Penerbit Universiti Malaysia Pahang 2016 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/16156/1/ftek-2016-9.pdf Senthilnathan, B. and Maheswaran, A. and Gopalasatheeskumar, K. and Masilamani, K. and Raihana Z., Edros (2016) Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles. International Journal of Engineering Technology And Sciences (IJETS), 6 (1). pp. 64-70. ISSN 2289-697X http://ijets.ump.edu.my/images/archive/Vol6/9.pdf DOI: 10.15282/ijets.6.2016.1.9.1059
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Senthilnathan, B.
Maheswaran, A.
Gopalasatheeskumar, K.
Masilamani, K.
Raihana Z., Edros
Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles
description In this work, polymeric nanoparticles containing Pregabalin was prepared and optimized the ideal concentration of polymer based on its in vitro release profile for a period of 24hrs.The nanoparticles were prepared by solvent displacement method using various concentrations of Eudragit S100 (EPNP1-EPNP5). The prepared nanoparticles were characterized for its particle size, zeta potential, drug content, entrapment efficiency and invitro drug release profile. The preformulation study results confirmed the compatibility between the drug and other excipients used in the formulation. The optimized formulation was selected based on its particle size, entrapment efficiency and in vitro drug release profile. The formulation which contains 300mg of Eudragit S100 (EPNP5) was selected as optimized concentration for the controlled release of Pregabalin for a period of 24hrs.
format Article
author Senthilnathan, B.
Maheswaran, A.
Gopalasatheeskumar, K.
Masilamani, K.
Raihana Z., Edros
author_facet Senthilnathan, B.
Maheswaran, A.
Gopalasatheeskumar, K.
Masilamani, K.
Raihana Z., Edros
author_sort Senthilnathan, B.
title Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles
title_short Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles
title_full Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles
title_fullStr Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles
title_full_unstemmed Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles
title_sort formulation and evaluation of pregabalin loaded eudragit s100 nanoparticles
publisher Penerbit Universiti Malaysia Pahang
publishDate 2016
url http://umpir.ump.edu.my/id/eprint/16156/
http://umpir.ump.edu.my/id/eprint/16156/
http://umpir.ump.edu.my/id/eprint/16156/
http://umpir.ump.edu.my/id/eprint/16156/1/ftek-2016-9.pdf
first_indexed 2023-09-18T22:21:34Z
last_indexed 2023-09-18T22:21:34Z
_version_ 1777415691313348608

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