Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception

The antinociceptive effects produced by intraperitoneal administration of a novel synthetic chalcone, 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one (DMFP), were investigated in several mouse models of induced nociception. The administration of DMFP (0.1, 0.5, 1.0 and 5.0 mg/kg) produ...

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Main Authors:	Nur Izzati, Ismail, Lee, Ming-Tatt, Nordin, Lajis, Akhtar, Muhammad Nadeem, Ahmad, Akira, Perimal, Enoch Kumar, Daud, Ahmad Israf, Mohd Roslan, Sulaiman
Format:	Article
Language:	English
Published:	MDPI - Open Access Publishing 2016
Subjects:	QR Microbiology
Online Access:	http://umpir.ump.edu.my/id/eprint/16813/ http://umpir.ump.edu.my/id/eprint/16813/ http://umpir.ump.edu.my/id/eprint/16813/ http://umpir.ump.edu.my/id/eprint/16813/1/fist-2016-nadeem-Antinociceptive%20Effect%20of%203-23-Dimethoxyphenyl5.pdf

id	ump-16813
recordtype	eprints
spelling	ump-168132018-04-19T02:25:52Z http://umpir.ump.edu.my/id/eprint/16813/ Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception Nur Izzati, Ismail Lee, Ming-Tatt Nordin, Lajis Akhtar, Muhammad Nadeem Ahmad, Akira Perimal, Enoch Kumar Daud, Ahmad Israf Mohd Roslan, Sulaiman QR Microbiology The antinociceptive effects produced by intraperitoneal administration of a novel synthetic chalcone, 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one (DMFP), were investigated in several mouse models of induced nociception. The administration of DMFP (0.1, 0.5, 1.0 and 5.0 mg/kg) produced significant attenuation on the acetic acid-induced abdominal-writhing test. It also produced a significant increase in response latency time in the hot-plate test and a marked reduction in time spent licking the injected paw in both phases of the formalin-induced paw-licking test. In addition, it was also demonstrated that DMFP exhibited significant inhibition of the neurogenic nociceptive response induced by intraplantar injections of capsaicin and glutamate. Moreover, the antinociceptive effect of DMFP in the acetic acid-induced abdominal-writhing test and the hot-plate test was not antagonized by pretreatment with a non-selective opioid receptor antagonist, naloxone. Finally, DMFP did not show any toxic effects and/or mortality in a study of acute toxicity and did not interfere with motor coordination during the Rota-rod test. Our present results show that DMFP exhibits both peripheral and central antinociceptive effects. It was suggested that its peripheral antinociceptive activity is associated with attenuated production and/or release of NO and various pro-inflammatory mediators, while central antinociceptive activity seems to be unrelated to the opioidergic system, but could involve, at least in part, an interaction with the inhibition of capsaicin-sensitive fibers and the glutamatergic system. MDPI - Open Access Publishing 2016 Article PeerReviewed application/pdf en cc_by http://umpir.ump.edu.my/id/eprint/16813/1/fist-2016-nadeem-Antinociceptive%20Effect%20of%203-23-Dimethoxyphenyl5.pdf Nur Izzati, Ismail and Lee, Ming-Tatt and Nordin, Lajis and Akhtar, Muhammad Nadeem and Ahmad, Akira and Perimal, Enoch Kumar and Daud, Ahmad Israf and Mohd Roslan, Sulaiman (2016) Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception. Molecules, 21 (8). pp. 1-16. ISSN 1420-3049 (print); 1420-3049 (online) http://dx.doi.org/10.3390/molecules21081077 DOI: 10.3390/molecules21081077
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QR Microbiology
spellingShingle	QR Microbiology Nur Izzati, Ismail Lee, Ming-Tatt Nordin, Lajis Akhtar, Muhammad Nadeem Ahmad, Akira Perimal, Enoch Kumar Daud, Ahmad Israf Mohd Roslan, Sulaiman Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception
description	The antinociceptive effects produced by intraperitoneal administration of a novel synthetic chalcone, 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one (DMFP), were investigated in several mouse models of induced nociception. The administration of DMFP (0.1, 0.5, 1.0 and 5.0 mg/kg) produced significant attenuation on the acetic acid-induced abdominal-writhing test. It also produced a significant increase in response latency time in the hot-plate test and a marked reduction in time spent licking the injected paw in both phases of the formalin-induced paw-licking test. In addition, it was also demonstrated that DMFP exhibited significant inhibition of the neurogenic nociceptive response induced by intraplantar injections of capsaicin and glutamate. Moreover, the antinociceptive effect of DMFP in the acetic acid-induced abdominal-writhing test and the hot-plate test was not antagonized by pretreatment with a non-selective opioid receptor antagonist, naloxone. Finally, DMFP did not show any toxic effects and/or mortality in a study of acute toxicity and did not interfere with motor coordination during the Rota-rod test. Our present results show that DMFP exhibits both peripheral and central antinociceptive effects. It was suggested that its peripheral antinociceptive activity is associated with attenuated production and/or release of NO and various pro-inflammatory mediators, while central antinociceptive activity seems to be unrelated to the opioidergic system, but could involve, at least in part, an interaction with the inhibition of capsaicin-sensitive fibers and the glutamatergic system.
format	Article
author	Nur Izzati, Ismail Lee, Ming-Tatt Nordin, Lajis Akhtar, Muhammad Nadeem Ahmad, Akira Perimal, Enoch Kumar Daud, Ahmad Israf Mohd Roslan, Sulaiman
author_facet	Nur Izzati, Ismail Lee, Ming-Tatt Nordin, Lajis Akhtar, Muhammad Nadeem Ahmad, Akira Perimal, Enoch Kumar Daud, Ahmad Israf Mohd Roslan, Sulaiman
author_sort	Nur Izzati, Ismail
title	Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception
title_short	Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception
title_full	Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception
title_fullStr	Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception
title_full_unstemmed	Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception
title_sort	antinociceptive effect of 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in mice models of induced nociception
publisher	MDPI - Open Access Publishing
publishDate	2016
url	http://umpir.ump.edu.my/id/eprint/16813/ http://umpir.ump.edu.my/id/eprint/16813/ http://umpir.ump.edu.my/id/eprint/16813/ http://umpir.ump.edu.my/id/eprint/16813/1/fist-2016-nadeem-Antinociceptive%20Effect%20of%203-23-Dimethoxyphenyl5.pdf
first_indexed	2023-09-18T22:22:49Z
last_indexed	2023-09-18T22:22:49Z
_version_	1777415770189332480

Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception

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