Fabrication, Characterization and In Vitro Biocompatibility of Electrospun Hydroxyethyl Cellulose/poly (vinyl) Alcohol Nanofibrous Composite Biomaterial for Bone Tissue Engineering

Development ofnovel scaffold materials that mimic the extracellular matrix, architecturally and func- tionally, is becoming highly important to meet the demands of the advances in bone tissue engineering. This paper reports, the fabrication of natural polymer cellulose derived hydroxyethyl cellulose...

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Main Authors:	Chahal, Sugandha, Jahir Hussain, Fathima Shahitha, Kumar, Anuj, Mohammad Syaiful Bahari, Abdull Rasad, M. M., Yusoff
Format:	Article
Language:	English
Published:	Elsevier 2016
Subjects:	QD Chemistry
Online Access:	http://umpir.ump.edu.my/id/eprint/16970/ http://umpir.ump.edu.my/id/eprint/16970/ http://umpir.ump.edu.my/id/eprint/16970/ http://umpir.ump.edu.my/id/eprint/16970/1/fist-2016-fathima-Fabrication%2C%20characterization%20and%20in%20vitro1.pdf

id	ump-16970
recordtype	eprints
spelling	ump-169702018-07-26T06:51:58Z http://umpir.ump.edu.my/id/eprint/16970/ Fabrication, Characterization and In Vitro Biocompatibility of Electrospun Hydroxyethyl Cellulose/poly (vinyl) Alcohol Nanofibrous Composite Biomaterial for Bone Tissue Engineering Chahal, Sugandha Jahir Hussain, Fathima Shahitha Kumar, Anuj Mohammad Syaiful Bahari, Abdull Rasad M. M., Yusoff QD Chemistry Development ofnovel scaffold materials that mimic the extracellular matrix, architecturally and func- tionally, is becoming highly important to meet the demands of the advances in bone tissue engineering. This paper reports, the fabrication of natural polymer cellulose derived hydroxyethyl cellulose(HEC) based nanostructured scaffolds with uniform fiber morphology through electrospinning. Poly(vinyl alcohol) (PVA) was used as anionic solvent for supporting the electrospinning of HEC. Scanning electron microscopy and ImageJ analysis revealed the formation of non-woven nanofibers with well-defined porous architecture. The interactions between HECandPVA in the electrospun nanofibers were studied by differential scanning calorimetry, X-raydiffraction, dynamic mechanical analysis thermo-gravimetric analysis; Fourier transform-infrared spectroscopy,X-ray photoelectronspectroscopy and tensiletest. The mechanical properties of scaffolds were significantly altered with different ratios of HEC/PVA. Further, the biocompatibility of HEC/PVAscaffolds was evaluated using human osteosarcomacells. TheSEM images revealed favorable cellsattachment and spreading on the nanofibrous scaffolds and MTS assay showed increased cell proliferation afterdifferent time periods. Thus, these results indicate that HEC based nanofibrous scaffolds will be a promising candidate for bone tissue engineering. Elsevier 2016 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/16970/1/fist-2016-fathima-Fabrication%2C%20characterization%20and%20in%20vitro1.pdf Chahal, Sugandha and Jahir Hussain, Fathima Shahitha and Kumar, Anuj and Mohammad Syaiful Bahari, Abdull Rasad and M. M., Yusoff (2016) Fabrication, Characterization and In Vitro Biocompatibility of Electrospun Hydroxyethyl Cellulose/poly (vinyl) Alcohol Nanofibrous Composite Biomaterial for Bone Tissue Engineering. Chemical Engineering Science, 144. pp. 17-29. ISSN 0009-2509 http://dx.doi.org/10.1016/j.ces.2015.12.030 doi: 10.1016/j.ces.2015.12.030
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Chahal, Sugandha Jahir Hussain, Fathima Shahitha Kumar, Anuj Mohammad Syaiful Bahari, Abdull Rasad M. M., Yusoff Fabrication, Characterization and In Vitro Biocompatibility of Electrospun Hydroxyethyl Cellulose/poly (vinyl) Alcohol Nanofibrous Composite Biomaterial for Bone Tissue Engineering
description	Development ofnovel scaffold materials that mimic the extracellular matrix, architecturally and func- tionally, is becoming highly important to meet the demands of the advances in bone tissue engineering. This paper reports, the fabrication of natural polymer cellulose derived hydroxyethyl cellulose(HEC) based nanostructured scaffolds with uniform fiber morphology through electrospinning. Poly(vinyl alcohol) (PVA) was used as anionic solvent for supporting the electrospinning of HEC. Scanning electron microscopy and ImageJ analysis revealed the formation of non-woven nanofibers with well-defined porous architecture. The interactions between HECandPVA in the electrospun nanofibers were studied by differential scanning calorimetry, X-raydiffraction, dynamic mechanical analysis thermo-gravimetric analysis; Fourier transform-infrared spectroscopy,X-ray photoelectronspectroscopy and tensiletest. The mechanical properties of scaffolds were significantly altered with different ratios of HEC/PVA. Further, the biocompatibility of HEC/PVAscaffolds was evaluated using human osteosarcomacells. TheSEM images revealed favorable cellsattachment and spreading on the nanofibrous scaffolds and MTS assay showed increased cell proliferation afterdifferent time periods. Thus, these results indicate that HEC based nanofibrous scaffolds will be a promising candidate for bone tissue engineering.
format	Article
author	Chahal, Sugandha Jahir Hussain, Fathima Shahitha Kumar, Anuj Mohammad Syaiful Bahari, Abdull Rasad M. M., Yusoff
author_facet	Chahal, Sugandha Jahir Hussain, Fathima Shahitha Kumar, Anuj Mohammad Syaiful Bahari, Abdull Rasad M. M., Yusoff
author_sort	Chahal, Sugandha
title	Fabrication, Characterization and In Vitro Biocompatibility of Electrospun Hydroxyethyl Cellulose/poly (vinyl) Alcohol Nanofibrous Composite Biomaterial for Bone Tissue Engineering
title_short	Fabrication, Characterization and In Vitro Biocompatibility of Electrospun Hydroxyethyl Cellulose/poly (vinyl) Alcohol Nanofibrous Composite Biomaterial for Bone Tissue Engineering
title_full	Fabrication, Characterization and In Vitro Biocompatibility of Electrospun Hydroxyethyl Cellulose/poly (vinyl) Alcohol Nanofibrous Composite Biomaterial for Bone Tissue Engineering
title_fullStr	Fabrication, Characterization and In Vitro Biocompatibility of Electrospun Hydroxyethyl Cellulose/poly (vinyl) Alcohol Nanofibrous Composite Biomaterial for Bone Tissue Engineering
title_full_unstemmed	Fabrication, Characterization and In Vitro Biocompatibility of Electrospun Hydroxyethyl Cellulose/poly (vinyl) Alcohol Nanofibrous Composite Biomaterial for Bone Tissue Engineering
title_sort	fabrication, characterization and in vitro biocompatibility of electrospun hydroxyethyl cellulose/poly (vinyl) alcohol nanofibrous composite biomaterial for bone tissue engineering
publisher	Elsevier
publishDate	2016
url	http://umpir.ump.edu.my/id/eprint/16970/ http://umpir.ump.edu.my/id/eprint/16970/ http://umpir.ump.edu.my/id/eprint/16970/ http://umpir.ump.edu.my/id/eprint/16970/1/fist-2016-fathima-Fabrication%2C%20characterization%20and%20in%20vitro1.pdf
first_indexed	2023-09-18T22:23:06Z
last_indexed	2023-09-18T22:23:06Z
_version_	1777415787679580160

Fabrication, Characterization and In Vitro Biocompatibility of Electrospun Hydroxyethyl Cellulose/poly (vinyl) Alcohol Nanofibrous Composite Biomaterial for Bone Tissue Engineering

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