A Facile Synthesis Method of Hydroxyethyl Cellulose-Silver Nanoparticle Scaffolds for Skin Tissue Engineering Applications

Green porous and ecofriendly scaffolds have been considered as one of the potent candidates for tissue engineering substitutes. The objective of this study is to investigate the biocompatibility of hydroxyethyl cellulose (HEC)/silver nanoparticles (AgNPs), prepared by the green synthesis method as a...

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Main Authors:	Farah Hanani, Zulkifli, Jahir Hussain, Fathima Shahitha, Zeyohannes, Senait Sileshi, Mohammad Syaiful Bahari, Abdull Rasad, M. M., Yusoff
Format:	Article
Language:	English English
Published:	Elsevier Ltd 2017
Subjects:	QD Chemistry
Online Access:	http://umpir.ump.edu.my/id/eprint/17573/ http://umpir.ump.edu.my/id/eprint/17573/ http://umpir.ump.edu.my/id/eprint/17573/ http://umpir.ump.edu.my/id/eprint/17573/1/fist-2017-hanani-A%20facile%20synthesis%20method%20of%20hydroxyethyl%20cellulose1.pdf http://umpir.ump.edu.my/id/eprint/17573/7/A%20Facile%20Synthesis%20Method%20of%20Hydroxyethyl%20Cellulose-Silver.pdf

id	ump-17573
recordtype	eprints
spelling	ump-175732018-07-26T06:53:38Z http://umpir.ump.edu.my/id/eprint/17573/ A Facile Synthesis Method of Hydroxyethyl Cellulose-Silver Nanoparticle Scaffolds for Skin Tissue Engineering Applications Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha Zeyohannes, Senait Sileshi Mohammad Syaiful Bahari, Abdull Rasad M. M., Yusoff QD Chemistry Green porous and ecofriendly scaffolds have been considered as one of the potent candidates for tissue engineering substitutes. The objective of this study is to investigate the biocompatibility of hydroxyethyl cellulose (HEC)/silver nanoparticles (AgNPs), prepared by the green synthesis method as a potential host material for skin tissue applications. The substrates which contained varied concentrations of AgNO3 (0.4%–1.6%) were formed in the presence of HEC, were dissolved in a single step in water. The presence of AgNPs was confirmed visually by the change of color from colorless to dark brown, and was fabricated via freeze-drying technique. The outcomes exhibited significant porosity of > 80%, moderate degradation rate, and tremendous value of water absorption up to 1163% in all samples. These scaffolds of HEC/AgNPs were further characterized by SEM, UV–Vis, ATR-FTIR, TGA, and DSC. All scaffolds possessed open interconnected pore size in the range of 50–150 μm. The characteristic peaks of Ag in the UV–Vis spectra (417–421 nm) revealed the formation of AgNPs in the blend composite. ATR-FTIR curve showed new existing peak, which implies the oxidation of HEC in the cellulose derivatives. The DSC thermogram showed augmentation in Tg with increased AgNO3 concentration. Preliminary studies of cytotoxicity were carried out in vitro by implementation of the hFB cells on the scaffolds. The results substantiated low toxicity of HEC/AgNPs scaffolds, thus exhibiting an ideal characteristic in skin tissue engineering applications. Elsevier Ltd 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/17573/1/fist-2017-hanani-A%20facile%20synthesis%20method%20of%20hydroxyethyl%20cellulose1.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/17573/7/A%20Facile%20Synthesis%20Method%20of%20Hydroxyethyl%20Cellulose-Silver.pdf Farah Hanani, Zulkifli and Jahir Hussain, Fathima Shahitha and Zeyohannes, Senait Sileshi and Mohammad Syaiful Bahari, Abdull Rasad and M. M., Yusoff (2017) A Facile Synthesis Method of Hydroxyethyl Cellulose-Silver Nanoparticle Scaffolds for Skin Tissue Engineering Applications. Materials Science and Engineering: C, 79. pp. 151-160. ISSN 0928-4931 https://doi.org/10.1016/j.msec.2017.05.028 DOI: 10.1016/j.msec.2017.05.028
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English English
topic	QD Chemistry
spellingShingle	QD Chemistry Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha Zeyohannes, Senait Sileshi Mohammad Syaiful Bahari, Abdull Rasad M. M., Yusoff A Facile Synthesis Method of Hydroxyethyl Cellulose-Silver Nanoparticle Scaffolds for Skin Tissue Engineering Applications
description	Green porous and ecofriendly scaffolds have been considered as one of the potent candidates for tissue engineering substitutes. The objective of this study is to investigate the biocompatibility of hydroxyethyl cellulose (HEC)/silver nanoparticles (AgNPs), prepared by the green synthesis method as a potential host material for skin tissue applications. The substrates which contained varied concentrations of AgNO3 (0.4%–1.6%) were formed in the presence of HEC, were dissolved in a single step in water. The presence of AgNPs was confirmed visually by the change of color from colorless to dark brown, and was fabricated via freeze-drying technique. The outcomes exhibited significant porosity of > 80%, moderate degradation rate, and tremendous value of water absorption up to 1163% in all samples. These scaffolds of HEC/AgNPs were further characterized by SEM, UV–Vis, ATR-FTIR, TGA, and DSC. All scaffolds possessed open interconnected pore size in the range of 50–150 μm. The characteristic peaks of Ag in the UV–Vis spectra (417–421 nm) revealed the formation of AgNPs in the blend composite. ATR-FTIR curve showed new existing peak, which implies the oxidation of HEC in the cellulose derivatives. The DSC thermogram showed augmentation in Tg with increased AgNO3 concentration. Preliminary studies of cytotoxicity were carried out in vitro by implementation of the hFB cells on the scaffolds. The results substantiated low toxicity of HEC/AgNPs scaffolds, thus exhibiting an ideal characteristic in skin tissue engineering applications.
format	Article
author	Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha Zeyohannes, Senait Sileshi Mohammad Syaiful Bahari, Abdull Rasad M. M., Yusoff
author_facet	Farah Hanani, Zulkifli Jahir Hussain, Fathima Shahitha Zeyohannes, Senait Sileshi Mohammad Syaiful Bahari, Abdull Rasad M. M., Yusoff
author_sort	Farah Hanani, Zulkifli
title	A Facile Synthesis Method of Hydroxyethyl Cellulose-Silver Nanoparticle Scaffolds for Skin Tissue Engineering Applications
title_short	A Facile Synthesis Method of Hydroxyethyl Cellulose-Silver Nanoparticle Scaffolds for Skin Tissue Engineering Applications
title_full	A Facile Synthesis Method of Hydroxyethyl Cellulose-Silver Nanoparticle Scaffolds for Skin Tissue Engineering Applications
title_fullStr	A Facile Synthesis Method of Hydroxyethyl Cellulose-Silver Nanoparticle Scaffolds for Skin Tissue Engineering Applications
title_full_unstemmed	A Facile Synthesis Method of Hydroxyethyl Cellulose-Silver Nanoparticle Scaffolds for Skin Tissue Engineering Applications
title_sort	facile synthesis method of hydroxyethyl cellulose-silver nanoparticle scaffolds for skin tissue engineering applications
publisher	Elsevier Ltd
publishDate	2017
url	http://umpir.ump.edu.my/id/eprint/17573/ http://umpir.ump.edu.my/id/eprint/17573/ http://umpir.ump.edu.my/id/eprint/17573/ http://umpir.ump.edu.my/id/eprint/17573/1/fist-2017-hanani-A%20facile%20synthesis%20method%20of%20hydroxyethyl%20cellulose1.pdf http://umpir.ump.edu.my/id/eprint/17573/7/A%20Facile%20Synthesis%20Method%20of%20Hydroxyethyl%20Cellulose-Silver.pdf
first_indexed	2023-09-18T22:24:21Z
last_indexed	2023-09-18T22:24:21Z
_version_	1777415866731724800

A Facile Synthesis Method of Hydroxyethyl Cellulose-Silver Nanoparticle Scaffolds for Skin Tissue Engineering Applications

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